Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3‐Diphenyl‐1,3‐propanedione

Horozić, Emir; Suljagić, Jasmin; Husejnagić, Darja; Hasić, Nusreta; Bratovčić, Amra

doi:10.7251/jepm1902112h

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Studies conducted in the past two years on complexes of selected d-block metals and Schiff bases derived from ninhydrin and amino acids have shown significant reduction potential and a high degree of neutralization of DPPH radicals in in vitro studies [18][19][20][21]. Figure 2 shows the general structure of metal complexes with Schiff bases derived from selected amino acids and ninhydrins, where R is the amino acid residue (phenylalanine, glycine, tryptophan, methionine, histidine, cysteine) and M is the selected metals (copper, cobalt, iron, nickel, silver).…”

Section: Metal Complexesmentioning

confidence: 99%

Metal complexes as potential agents for neutralizing free radicals: a review of in vitro studies

Imamovic¹,

Horozić²,

Salkovic³

et al. 2023

Acta Med Sal

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Metal complexes due to their antibacterial, antifungal, antitumor and antioxidant properties have been extremely studied today. A large number of metal complexes have the ability to neutralize free radicals, which most often occur as a result of metabolic processes in the body, smoking, exposure to radiation and chemical substances. Testing the antioxidant capacity of metal complexes can be tested by various methods in vitro and in vivo. This paper will present the efficiency of neutralization of free radicals by metal complexes synthesized in the past few years using different ligands, as well as the most commonly used methods for testing the antioxidant capacity of this group of compounds.Â

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Section: Metal Complexesmentioning

confidence: 99%

Metal complexes as potential agents for neutralizing free radicals: a review of in vitro studies

Imamovic¹,

Horozić²,

Salkovic³

et al. 2023

Acta Med Sal

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“…Regarding AO activity, in ligand complex pairs (L1-1 and L2-2), highest inhibitory action was seen in complexes 1 and 2 (Figure 12). Schiff base was obtained from benzidine with 1,3-diphenyl-1,3-propanedione and its AO and AF activities were studied by Horozić et al [43] (Figure 13). The AO activity was studied in vitro using DPPH method.…”

Section: Heteroatomic Dyes and Schiff Base Compoundsmentioning

confidence: 99%

Chemistry in biosystem—A contemporary review of Schiff bases and their metal complexes as antioxidants and anti-fungal agents

Sachdeva

Dheer

Hooda

et al. 2023

ACE

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Schiff bases are a class of organic compounds which have good chelating properties. Due to this, they can form complexes with metal ions of the transition series. Schiff bases and their derivatives are bioactive and hence find widespread uses in various fields of inorganic, organic and medicinal chemistry. These are synthesised by condensation reactions and have been studied extensively as they can exhibit biological properties like anti-oxidant, anti-fungal, anti-cancer, anti-bacterial and anti-microbial, apart from finding uses in the field of material science. With the advent of nanotechnology and its increasing importance, the introduction of nanoparticles of Schiff bases can increase the effectiveness of their various biological properties. In the present article, we aim at providing an exhaustive review of the behaviour of metal complexes of Schiff bases and their various derivatives as anti-oxidant and anti-fungal agents. The most pertinent and contemporary literature has been chosen for this review article.

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“…Ongoing research is focused on understanding the biology of K. pneumonia and developing new treatments and preventative measures to combat its spread. 6 Pseudomonas aeruginosa, gram-negative bacterium that is widespread in clay and moisture is an adaptable disease-causing bacterium that can trigger a range of infections, notably in hospitalized patients, including pneumonia, sepsis, pyelonephritis, and surgical wound infestation. P. aeruginosa is known to develop resistance to multiple antibiotics, making treatment challenging.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antibacterial Evaluation and in silico Docking of Schiff Base as a Potential Inhibitor of Nucleoside Diphosphate Kinases

Tomer,

Vats,

Bansal

et al. 2024

Ind. J. Pharm. Edu. Res

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Aim: Schiff bases are vital Compounds of organic chemistry; they have exhibited more potential biological activities namely antiviral, antibacterial, and antifungal characteristics. Molecular docking studies suggested that strong binding energies, as well as favorable hydrogen bonds and hydrophobic interactions, could be beneficial for the pharmacological application of the compounds. Moreover, the aid of the ADMET score may support the therapeutic action of potential pharmaceutical compounds. Materials and Methods: In the present work, In vitro studies were conducted on five Schiff bases named BIP, CIP, PT, NIP, and DPIP against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. In silico studies were also performed on the same five Schiff bases, evaluating their interaction with the target proteins of Staphylococcus aureus and Escherichia coli. Results: In vitro results of BIP and NIP showed mild MIC (minimum inhibition concentration) against Staphylococcus aureus and Escherichia Coli respectively, while PT showed good MIC against pathogenic bacteria Staphylococcus aureus which was upheld by in silico study. Conclusion: We hope the findings of the present study should contribute to developing a good anti-bacterial drug.

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Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3‐Diphenyl‐1,3‐propanedione

Cited by 4 publications

References 10 publications

Metal complexes as potential agents for neutralizing free radicals: a review of in vitro studies

Metal complexes as potential agents for neutralizing free radicals: a review of in vitro studies

Chemistry in biosystem—A contemporary review of Schiff bases and their metal complexes as antioxidants and anti-fungal agents

In vitro Antibacterial Evaluation and in silico Docking of Schiff Base as a Potential Inhibitor of Nucleoside Diphosphate Kinases

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