Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives

Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells

“…Another class demonstrates the enthusiasm researchers have for grafting metallocenes and metal carbonyls to a variety of biomolecules to modify their biological effects. [12] These therapeutic bioconjugates include steroidal [13][14][15] and nonsteroidal [16][17][18][19][20][21][22][23] endocrine modulators, natural products, [24][25][26][27] and others. [28][29][30][31][32][33][34] In these cases, the often covalently grafted organometallic unit is usually inert to ligand substitution, but potentiates the activity of the biomolecule via modification of the pharmacokinetic profile or acts as a structural mimic.…”

Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes

“…On the other hand, the influence of modifying the paclitaxel skeleton on its cytotoxicity strongly depends on the modification site, for example, acylation or epimerisation of the 7-OH groupu sually do not influence or even lead to al ack of activity of the resulting compound, whereas modification of the 3-benzoyloxy group usually improves cytotoxicity. [14] Depending on the nature of the metal-ligand bond, bioactive organometallicc ompoundsm ay feature covalent metal-carbon bonds and/orl abile ligands. Am etal atom in various oxidations tates gives access to structural diversity and biological properties that are differentf rom those of typical organic compounds.…”

“…[9] The success of platinum-based complexes,s uch as cisplatin, in anticancer therapy stimulated to search for new metal-containinga nticancer drug candidates.T remendous progress in bioorganometallic chemistry has led to the development of anticancer, [10] antimalarial [10a, 11] and antibacterial [12] compounds in recent years. Many ferrocenyl compounds have recently been prepared throughc onjugation of af errocenem oiety with nucleobases, [13] peptides, vitamins [14] or phenols, [15] which exhibited significant anticancer, [16] antimalarial [11a, 17] or antibacterial [18] activity.S ome of these compounds exhibited unexpected novel properties, for example, ferrocenyl curcuminoids interfered with microtubule polymerisation. [14] Depending on the nature of the metal-ligand bond, bioactive organometallicc ompoundsm ay feature covalent metal-carbon bonds and/orl abile ligands.…”

Ferrocene incorporated selenoureas as anticancer agents

“…Earlier attempts on ferrocene derivatives for their biological applications were individualistic in nature and it was known in 1978 (compound 1) that they are active against lymphocytic leukemia P-388 [19] (Chart 1, compound [1][2][3][4][5][6][7][8][9][10]. Other similar type of findings have shown the activity of ferrocene derivatives against lungs carcinoma (compound 2) [20], 70% tumor growth inhibition (compound 3) against Ca-755 cell lines [21] and 100% inhibition of solid (compound 4) tumor [22]. But detail studies have opened new horizons of research on ferrocene.…”