Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds

Parmar, Virinder S.; Sharma, Nikhil; Husain, M. I.; Watterson, Arthur C.; Kumar, Jayant; Samuelson, Lynne A.; Cholli, Ashok L.; Prasad, Ashok K.; Kumar, Ajay; Malhotra, Sanjay V.; Kumar, Naresh; Jha, Amitabh; Singh, Àmarjit; Singh, Ishwar; Himanshu, .; Vats, Archana; Shakil, Najam A.; Trikha, S. K.; Mukherjee, Shubasish; Sharma, Sunil K.; Singh, Sanjay Kumar; Jha, Hriday N; Olsen, Carl Erik; Stove, Christophe; Bracke, Marc; Mareel, Marc

doi:10.1016/s0968-0896(02)00539-4

Cited by 46 publications

(18 citation statements)

References 21 publications

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“…3,5-Diarylisoxazoles have been studied recently as potential anti-cancer [1] and anti-microbial agents [2], as potential estrogen receptor modulators [3], as liquid crystals [4], and as linear dyes with application to light-harvesting systems [5]. Previously, we have described the convenient C-4 halogenation (Cl, Br, or I) of a series of these compounds, using N-halosuccinimides [6].…”

Section: Introductionmentioning

confidence: 99%

Nuclear fluorination of 3,5-diarylisoxazoles with Selectfluor®

Stephens

Blake

2004

Journal of Fluorine Chemistry

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Section: Introductionmentioning

confidence: 99%

Nuclear fluorination of 3,5-diarylisoxazoles with Selectfluor®

Stephens

Blake

2004

Journal of Fluorine Chemistry

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“…Among the O-allylated chalcones, replacement of the B-phenyl ring with a furan-2-yl group was found to exhibit the strongest anti-invasive properties [122,144].…”

Section: Inhibition Of Invasionmentioning

confidence: 99%

Dietary chalcones with chemopreventive and chemotherapeutic potential

et al. 2011

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Chalcones are absorbed in the daily diet and appear to be promising cancer chemopreventive agents. Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. This family possesses an interesting spectrum of biological activities, including antioxidative, antibacterial, anti-inflammatory, anticancer, cytotoxic, and immunosuppressive potential. Compounds of this family have been shown to interfere with each step of carcinogenesis, including initiation, promotion and progression. Moreover, numerous compounds from the family of dietary chalcones appear to show activity against cancer cells, suggesting that these molecules or their derivatives may be considered as potential anticancer drugs. This review will focus primarily on prominent members of the chalcone family with an 1,3-diphenyl-2-propenon core structure. Specifically, the inhibitory effects of these compounds on the different steps of carcinogenesis that reveal interesting chemopreventive and chemotherapeutic potential will be discussed.

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“…Chalcones exhibit many pharmacological activities, including antileishmanial 3 , antiinflammatory 4,6 , antimitotic 7 , antiinvasive 8,9 , as well as antituberculosis 10 , antifungal 11 , cysteinyl leukotriene receptor-1 [CyLT1](LTD4) antagonist 12 , antimalarial 13,14 , antiplasmodial, immunosupressive, cytotoxic, antitumor, and antioxidant properties 15 , anti fibrogenic activities and modulation of P-glycoproteinmediated multi-drug resistance 16 .…”

Section: Fig 1: Chalconementioning

confidence: 99%

Untitled

2012

IJPSR

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In the present investigation, 4-chloro acetophenone on condensation with 2-nitro benzaldehydes in methanolic NaOH solution yielded the corresponding chalcone. These chalcone were further reacted with Isonicotyl hydrazide and semicarbazide in ethanol which led to the formation of chalcone Isonicotyl hydrazone and chalcone semicarbazone derivatives respectively. The newly synthesized derivatives and there copper complexes were characterized on the basis of their chemical properties and spectroscopic data such as IR, NMR and UV. All newly synthesized compounds were evaluated for their antibacterial activities against E. coli and S. aureus also for antifungal activities against P. notatum.

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Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds

Cited by 46 publications

References 21 publications

Nuclear fluorination of 3,5-diarylisoxazoles with Selectfluor®

Nuclear fluorination of 3,5-diarylisoxazoles with Selectfluor®

Dietary chalcones with chemopreventive and chemotherapeutic potential

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