Synthesis, characterization and <i>in vivo</i> antitumor effect of new α,β-unsaturated-2,5-disubstituted-1,3,4-oxadiazoles

Fray, Marwa; ELBini-Dhouib, Ines; Hamzi, Imane; Doghri, Raoudha; Srairi-Abid, Najet; Lesur, David; Benazza, Mohammed; Abidi, Rym; Barhoumi‐Slimi, Thouraya

doi:10.1080/00397911.2022.2053993

Cited by 3 publications

(2 citation statements)

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“…Notably, some of these products exhibited a remarkable antiproliferative effect against HepG‐2 and CNE‐2 human cancer cell lines [19] . Furthermore, it has been determined that α,β‐unsaturated‐2,5‐disubstituted‐1,3,4‐oxadiazoles can function as potent anti‐melanoma agents without manifesting any discernible toxic effects [20] …”

Section: Introductionmentioning

confidence: 99%

“…[19] Furthermore, it has been determined that α,β-unsaturated-2,5-disubstituted-1,3,4-oxadiazoles can function as potent anti-melanoma agents without manifesting any discernible toxic effects. [20] This study embarks on an exploration of the anticancer potential harbored by newly synthesized α,β-unsaturated compounds rooted in a steadfast phenylacrylonitrile base. Our research delves into their impact on three distinct cancer cell lines and aims to elucidate their potential molecular targets via molecular docking.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Unraveling the Anticancer Potential of Cinnamonitrile Derivatives: In vitro Evaluation and Molecular Docking

Faghih‐Mirzaei,

Kavousi,

Langarizadeh

et al. 2023

ChemistrySelect

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Cancer remains a formidable global healthcare challenge, driving relentless research efforts. Among the diverse compounds explored for their potential in combating cancer, α,β‐unsaturated compounds have exhibited intriguing biological activities, including anticancer properties. In this study, we embarked on synthesizing novel α,β‐unsaturated compounds anchored by a phenylacrylonitrile base using the Knoevenagel reaction. Our investigation delved into the cytotoxicity of these compounds, where two standouts, 3 f and 3 g, demonstrated remarkable antiproliferative efficacy comparable to the established chemotherapy drug, doxorubicin, when tested against various cancer cell lines. Additionally, the influence of these compounds was evident as DNA fragmentation became apparent after a mere 24‐hour exposure. Molecular docking analysis unveiled a compelling interaction between our synthesized compounds and the P38‐α receptor, a pivotal player in the Mitogen‐Activated Protein (MAP) kinase 14 pathway. This revelation suggests the potential of our compounds to target this receptor, opening new avenues for further exploration. Our research not only underscores the promising anticancer potential of these α,β‐unsaturated compounds but also identifies a specific molecular target, P38‐α, paving the way for future investigations in cancer therapeutics. In an ever‐evolving quest to combat cancer, this study contributes valuable insights that may hold the key to innovative treatment strategies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%