Synthesis, characterization and in vitro validation of a magnetic zeolite nanocomposite with T2-MRI properties towards theranostic applications

Vilaça, Natália; Gallo, Juan; Fernandes, Rui; Figueiredo, Francisco; Fonseca, A.; Baltazar, Fátima; Neves, Isabel C.; Bañobre‐López, Manuel

doi:10.1039/c9tb00078j

Cited by 15 publications

(7 citation statements)

References 83 publications

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“…Tumor tissue has a good environment of blood flow supply to meet its efficient energy metabolism and supply and provide nutrition delivery, immune regulation inhibition, metabolite exclusion and cytokine secretion, and therefore, the state of angiogenesis often determines the malignant biological behaviors such as tumor growth, infiltration and metastasis [ 20 , 21 ]. Dynamic enhancement technology enables the analysis of functional information such as cellular composition, vascular permeability, interstitial pressure, blood flow supply, and extracellular space from a hemodynamic perspective through the dynamic distribution process of contrast agent inside the tumor [ 22 – 24 ]. It was concluded herein that dynamic enhanced MRI parameters such as K trans , K ep and V e were significantly higher in the breast cancer group than in the benign lesion group ( P < 0.05), indicating that K trans , K ep, and V e could provide a strong reference for early diagnosis of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Enhanced Magnetic Resonance Imaging versus Ultrasonic Diffused Optical Tomography in Early Diagnosis of Breast Cancer

Feng

Jiang

2022

Journal of Healthcare Engineering

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Objective. To compare the application value of dynamic enhanced magnetic resonance imaging (MRI) and ultrasonic diffused optical tomography (DOT) in early diagnosis of breast cancer. Methods. The clinical data of 110 female patients with breast diseases treated in our hospital from June 2018 to June 2021 were selected for the retrospective analysis, and the patients were divided into the benign lesion group (n = 50) and breast cancer group (n = 60) according to the pathologic findings. All patients received dynamic enhanced MRI and ultrasonic DOT examinations for the observation of lesion morphology and analysis of relevant parameters, so as to scientifically evaluate the diagnostic value of dynamic enhanced MRI and ultrasonic DOT for early breast cancer. Results. The dynamic enhanced MRI examination found that the proportions of irregular shape, increased vascular shadow, obscure boundary, spicule sign, heterogeneous enhancement, etc. of lesion were significantly higher in the breast cancer group than in the benign lesion group ( P < 0.05 ); parameters such as Ktrans, Kep, and Ve were significantly higher in the breast cancer group than in the benign lesion group ( P < 0.05 ); the ultrasonic DOT diagnosis found that the THC value was obviously lower in the benign lesion group than in the breast cancer group ( P < 0.05 ); compared with the pathologic findings, it was believed that combined diagnosis had significantly higher diagnosis accuracy rate, sensitivity, specificity, positive predictive value and negative predictive value than the dynamic enhanced MRI and ultrasonic DOT diagnosis alone ( P < 0.05 ); and after further analyzing the efficacy of the two diagnosis modalities in diagnosing early breast cancer by ROC curves, the result showed combined diagnosis > dynamic enhanced MRI > ultrasonic DOT. Conclusion. Both dynamic enhanced MRI and ultrasonic DOT present higher diagnostic value to early breast cancer, of which dynamic enhanced MRI obtains results closer to the pathologic findings and has diagnostic efficacy higher than ultrasonic DOT. But the combination of the two can significantly improve the diagnosis accuracy rate for early breast cancer, presenting higher diagnostic value.

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Section: Discussionmentioning

confidence: 99%

Dynamic Enhanced Magnetic Resonance Imaging versus Ultrasonic Diffused Optical Tomography in Early Diagnosis of Breast Cancer

Feng

Jiang

2022

Journal of Healthcare Engineering

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“…EDX analysis was conducted at 15 kV; an intensity map and SEM analysis were conducted at 5 kV. The average particle diameters of NaY zeolite [24] and the bimetallic catalysts were determined using ImageJ Software (University of Wisconsin, USA, 2019, Figure S2).…”

Section: Catalysts Characterizationmentioning

confidence: 99%

Fenton-Type Bimetallic Catalysts for Degradation of Dyes in Aqueous Solutions

et al. 2020

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Dye compounds are becoming a problematic class of pollutants for the environment, so it is important to develop stable catalysts for their elimination. First, several studies were performed with different Y zeolites (NaY, (NH4)Y and USY) in order to select the best support for the preparation of the bimetallic catalysts. In particular, NaY zeolite was used as the support for Fe, Cu and Mn metals to prepare mono and bimetallic Fenton-type catalysts by the ion exchange method. The catalysts were characterized by several techniques, such as chemical analysis, nitrogen physisorption, X-ray diffraction (XRD), scanning electron microscopy (SEM) and cyclic voltammetry studies. Characterization results revealed that the metals were successfully ion-exchanged within the NaY zeolite. The prepared catalysts were tested for the aqueous-phase degradation of dye compounds (Procion yellow (PY) and Tartrazine (Tar)) at atmospheric pressure and different temperatures, using H2O2 as the oxidant. All the investigated samples were found to be active in degrading the dyes through the Fenton-type process; however, the oxidation rate was found to be higher in the presence of the bimetallic catalysts. CuFe-NaY displays the best mineralization rate for PY oxidation while MnFe-NaY shows the highest activity for Tar degradation. This work may provide further insight into the design of Fenton-type bimetallic catalysts with improved catalytic properties for environmental remediation.

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“…The size distribution of the agglomerates of MNPAs follows a lognormal distribution, a model commonly used for particle size distribution, and the high standard deviation value is due to outliers in the agglomerate population. The agglomerate size of MNPs inside of cells, evidenced in TEM studies, [ 15,17,18 ] amounts to a few micrometers. The produced agglomerates in PVA films reach relevant agglomerate sizes, with a statistical presence of agglomerates with less than 5 µm in diameter of 42% and with most of the agglomerate population (62%) with a diameter under 10 µm.…”

Section: Resultsmentioning

confidence: 99%

“…Typical sizes were extracted from transmission electron microscopy (TEM) imaging studies of MNPs interacting with cells. [ 15,17,18 ]…”

Section: Introductionmentioning

confidence: 99%

Magnetic Field Mapping Around Individual Magnetic Nanoparticle Agglomerates Using Nitrogen‐Vacancy Centers in Diamond

Camarneiro

Bocquel

Gallo

et al. 2021

Part & Part Syst Charact

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A modified diamond–photonics based metrology is proposed to explore the magnetic fields created by agglomerates of magnetic nanoparticles (MNPs). MNPs are promising for environmental and medical applications; those proposed for cancer magnetic hyperthermia treatments are small superparamagnetic <20 nm iron oxide particles. Inside cells, they assemble in larger MNP agglomerates, reaching cross‐sections of several micrometers. Here, these conditions are reproduced and MNP agglomerates immobilized. Optically detected magnetic resonance (ODMR) signals recorded without a bias field in a confocal microscope and scanning across a homogenous shallow layer of fluorescent nitrogen‐vacancy centers in a bulk diamond sample placed in direct contact with the MNP agglomerates are used to determine magnetic fields with a spatial resolution of 500 nm in a lateral direction. This spatial resolution allows determining magnetic field maps around individual MNP agglomerates, for which magnetic fields with strengths ranging from 0.03 mT to maximal 1.2 mT in the direct vicinity of the agglomerates and with detectable fields up to 5 µm away from the agglomerates, are determined. Based on the findings, a pathway to non‐invasively study the micro/nano topology of MNP agglomerates is proposed.

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Synthesis, characterization and in vitro validation of a magnetic zeolite nanocomposite with T₂-MRI properties towards theranostic applications

Abstract: This study focusses on the development of a magnetic zeolite nanocomposite as a suitable platform towards the design of a theranostic system. Herein, we explored its ability to act as a T2-MRI contrast enhancer when magnetic nanoparticles are incorporated in its structure.

Cited by 15 publications

References 83 publications

Dynamic Enhanced Magnetic Resonance Imaging versus Ultrasonic Diffused Optical Tomography in Early Diagnosis of Breast Cancer

Dynamic Enhanced Magnetic Resonance Imaging versus Ultrasonic Diffused Optical Tomography in Early Diagnosis of Breast Cancer

Fenton-Type Bimetallic Catalysts for Degradation of Dyes in Aqueous Solutions

Magnetic Field Mapping Around Individual Magnetic Nanoparticle Agglomerates Using Nitrogen‐Vacancy Centers in Diamond

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