Synthesis, characterization and in vitro anticancer activity of thiabendazole-derived 1,2,3-triazole derivatives

Abstract

<p>Thiabendazolium salts with 1,2,3-triazole motifs were synthesized and characterized; they exhibit good cytotoxic activity.</p>

1,2,3‐Triazole hybrids as anticancer agents: A review

“…It was observed that triazole derivatives with a long alkyl chain length (58) showed higher antiproliferative activity than the compounds with a short alkyl chain length. [68] 1,2,3-Triazole incorporating 1,2,4-triazole hybrid 59 showed significant anticancer activity against MCF-7, with an IC 50 value of 0.31 μM, comparable to the standard drug doxorubicin, with IC 50 values of 0.65 (MCF-7) and 5.17 (Caco-2). [69] Imidazo[1,2-α]pyridine derivatives bearing the 1,2,3-triazole moiety 60 showed antiproliferative effects against lung (EBC-1) and pancreatic cancer cells (AsPc-1, Suit-2, and Mia-PaCa-2), with IC 50 values below 3.0 μM.…”

An Atom-Economic Method for 1,2,3-Triazole Derivatives via Oxidative [3 + 2] Cycloaddition Harnessing the Power of Electrochemical Oxidation and Click Chemistry

“…As mentioned above, the 1,2,3-triazole derivatives demonstrate wide-ranging biological activities. − Therefore, the binding interaction of newly synthesized 1,2,3-triazoles 2m and 2n with some selected targets such as PDE δ, human topoisomerase 1, and cyclooxygenase-2 has also been studied. X-ray crystal structures of the complexes (PDE δ- PDB code: 5X73, human topoisomerase 1- PDB code: 1A35, cyclooxygenase-2- PDB code: 1CX2) are used as model target proteins for docking.…”

“…For instance, 1,2,3-triazoles have shown a broad spectrum of biological activities such as antifungal, antibacterial, antimalarial, anticancer, antiprotozoal, and antileishmanial activities to name a few. Some triazole-containing molecules that are commercialized as drug molecules are shown in Figure .…”

Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery

“…1,2,3-triazole derivatives has attracted much attention due to their interesting pharmacological activities such as anticancer [ 46 , 47 , 48 ], antimalarial [ 49 ], antibacterial [ 50 , 51 ], antifungal [ 52 , 53 , 54 ], anti-inflammatory [ 55 ], and antiviral activities [ 56 , 57 ]. In addition, some 1,2,3-triazole-based derivatives are under clinical evaluation for their potential use in cancer treatment [ 58 ].…”