Synthesis, characterization, and fluorescence and cytotoxicity studies of a tetrarhenium molecular rectangle

Electron donor-acceptor properties of substituted pyridine ligands on fac-tricarbonylrhenium(I) systems

“…The fac product is a result of the strong trans directing nature of the CO ligands, that labilizes two equivalents of CO. Many groups have taken advantage of this reactivity to build molecular architectures such as squares [4,[21][22][23] and rectangles [24][25][26][27][28] because the two new ligands are forced into a cis arrangement in this family of structures.…”

A Novel Organometallic Rhenium Salt: DNA-Binding and Cytotoxicity Studies on Pancreatic, Breast and Lymphoma Cancers

“…Reactions of group VII metal carbonyls with monophosphines, diphosphines and diimines in alcohols provide a wide variety of organometallic complexes [1][2][3][4][5][6][7][8][9][10]. The reaction of Re 2 (CO) 10 with phen (1,10phenanthroline) in re uxed 1-pentanol produced the expected alkoxide, fac-(CO) 3 (phen)ReOC 5 H 11 and a dirhenium complex (minor product) [11].…”

“…The tetranuclear rhenium (I) complex [Re(µ-H)Re] + [Re(µ-OR) 3 Re] -, 2 is structurally unique and different from the known tetranuclear rhenium (I) molecular rectangles [9,10], cyclic tetranuclear platinum (II) and palladium (II) [13], ruthenium (II) [14], copper(II) [15], silver (I) [16], tin(IV) [17] and a whole host of related other tetranuclear metal complexes. Anticancer properties of numerous mono and dinuclear and a few trinuclear rhenium (I) complexes are known [18][19][20][21][22][23][24][25][26][27][28][29].…”

“…Anticancer properties of numerous mono and dinuclear and a few trinuclear rhenium (I) complexes are known [18][19][20][21][22][23][24][25][26][27][28][29]. However, examples of biological properties of tetranuclear rhenium complexes are scarce [9,12]. Herein, we report a preliminary in vitro binding studies of the tetranuclear rhenium (I) complex 2 with calf thymus DNA (CT-DNA) using various biophysical techniques and the anticancer activity of 2 on BxPC-3 pancreatic cancer, estrogen receptor positive MCF-7 breast cancer, triple negative MDA-MB-231 breast cancer, and U-937 lymphoma cells.…”

Sulfate Donor Based Dinuclear Heteroleptic Triple-Stranded Helicates from Sulfite and Ditopic Nitrogen Donor Ligands and Their Transformation to Dinuclear Homoleptic Double-Stranded Mesocates

“…Several metal-directed synthetic principles are currently available for making well-defined shapes and sizes of supramolecular coordination complexes (SCCs), including helicates and mesocates, which have potential applications in materials and medicinal fields. − Among the various synthetic approaches, the fac -Re­(CO) 3 core directed one-pot strategy, i.e., a combination of Re­(CO) 5 X (X = halide)/Re 2 (CO) 10 and organic building units, is a fruitful way to synthesize fac -Re­(CO) 3 core based SCCs, which have been gaining great interest in molecular recognition, organic transformation, photocatalysts for CO 2 reduction, bioimaging, and anticancer agents. − Due to their importance, new design principles have been emerging in order to improve the physiochemical properties of SCCs as well as hitherto unexplored molecules. Up to now, the research in this area has mainly been focused on modulating the organic ligands by tuning the denticity and/or spacer to introduce flexibility and decorating framework with functional units .…”