Synthesis, characterization and fabrication of sodium carboxymethyl-okra-gum-grafted-polymethacrylamide into sustained release tablet matrix

Patra, Sarat Kumar; Bala, Nripendra Nath; Nandi, Gouranga

doi:10.1016/j.ijbiomac.2020.09.025

Cited by 20 publications

(2 citation statements)

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“…Patra et al produced a prolonged-release tablet matrix for sodium carboxymethyl okra-gum-grafted polymethacrylamide (Na-CM-OG-g-PMA) copolymer [ 45 ]. The diclofenac sodium tablet formulation with S-CMOG-g-PMA with DCS-0.604 and %G-423.4 exhibited remarkable prolonged drug release (90% for 11.7 h) and a 72.0 similarity factor.…”

Section: Applications Of Derivatized Carboxymethylated Gumsmentioning

confidence: 99%

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Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

Baghel¹,

Sakure²,

Giri

et al. 2023

Pharmaceuticals

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Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured synthetics because of their intrinsic physicochemical characteristics. Studies showed that the carboxymethylation of polysaccharides considerably increases the aqueous solubility and bioactivities of inherent polysaccharides and offers structural diversity, but it also has some limitations that can be resolved by derivatization or the grafting of carboxymethylated gums. The swelling ratio, flocculation capacity, viscosity, partition coefficient, metal absorption properties, and thermosensitivity of natural polysaccharides have been improved as a result of these changes. In order to create better and functionally enhanced polysaccharides, researchers have modified the structures and properties of carboxymethylated gums. This review summarizes the various ways of modifying carboxymethylated gums, explores the impact that molecular modifications have on their physicochemical characteristics and bioactivities, and sheds light on various applications for the derivatives of carboxymethylated polysaccharides.

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Section: Applications Of Derivatized Carboxymethylated Gumsmentioning

confidence: 99%

“…These include the following factors: (1) Early gastrointestinal fluid erosion hinders the use of CMGs in sustained-release preparations for a longer time. Derivatization synergistically increases the sustaining capability [ 45 ]. (2) Derivatization increases thermostability as well as storage stability [ 46 ].…”

Section: Introductionmentioning

confidence: 99%