Synthesis, Characterization, and Exploration of Antimicrobial Activity of Copper Complex of Diamide Derivative of p-tert-butylcalix[4]arene

Memon, Shahabuddin; Chandio, Anwar Ali; Memon, Ayaz Ali; Panhwar, Qadeer Khan; Nizamani, Sarwat; Bhatti, Ashfaq A.; Brohi, Nazir A.

doi:10.1080/10406638.2015.1125375

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…In phytochemical analysis, polyphenolic compounds such as 4-tert-butylcalix 4 arene (58.52%) were detected and that has been reported for antimicrobial activity. 20 The presence of a high number of polyphenols was detected in GCMS analysis in C. flexuosus oil. Polyphenols such as catechin, gallic acid, quercetin, isoquercetin, tannic acid, and rutin present in C. citratus were reported earlier.…”

Section: Discussionmentioning

confidence: 94%

Antifungal Activity of Cymbopogon flexuosus Essential Oil and its Effect on Biofilm Formed by Candida parapsilosis and Candida tropicalis on Polystyrene and Polyvinyl Plastic Surfaces

Al-Ghanayem¹

2023

Ind. J. Pharm. Edu. Res

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Aim: To determine the antifungal and antibiofilm activity of Cymbopogon flexuosus (Lemongrass oil) against C. parapsilosis and C. tropicalis. Materials and Methods: Lemongrass oil, was analyzed by GC-MS. Antifungal activities, minimum inhibitory concentration, and minimum fungicidal concentration against C. parapsilosis and C. tropicalis were determined.The effect of LGO inhibiting biofilm formation by these Candida species on different surfaces was evaluated. Cytotoxicity of Cymbopogon flexuosus (Lemongrass oil) on human keratinocytes (HaCaT) cells was evaluated under in-vitro conditions. Results: The major compounds found in LGO were 4-tert-butylcalix 4 arene (58.52%), diethyl 3, 4-dihydro-1-naphthalenylester (8.13%), 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2, 8-dione (8.84%) and hexadecanoic acid (4.83%). The essential oil had a considerable antifungal activity against both the Candida species. Further, a sub MIC concentration (0.5%) in the medium inhibited the biofilm formation on polystyrene and polyvinyl plastic surfaces. The in-vitro cell viability of HaCaT keratinocytes in presence of LGO was studied and the IC 50 value was observed at 1250 µg/ml concentration. Conclusion:The active components of LGO with antifungal and biofilm activity can be effectively used for controlling the biofilm formation by C. parapsilosis and C. tropicalis on polystyrene and polyvinyl plastic surfaces. Further investigations on the bioactive components present in LGO may be useful to control biofilm-related infection.

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Section: Discussionmentioning

confidence: 94%

Antifungal Activity of Cymbopogon flexuosus Essential Oil and its Effect on Biofilm Formed by Candida parapsilosis and Candida tropicalis on Polystyrene and Polyvinyl Plastic Surfaces

Al-Ghanayem¹

2023

Ind. J. Pharm. Edu. Res

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“…1 filter paper (6 mm diameter) with 20 μL of different concentrations was placed on the surface of microbial Petri dishes and placed in an incubator at a temperature of 37°C and time period for 24 h. Antibacterial activity of the extracts (stem, flower, and leaf) was recorded against each microbial species by measuring the area of diameter inhibition in millimeters around the discs and the value of MIC was determined. All experiments were carried out three times [17][18][19].…”

Section: Determination Of Antimicrobial Activitiesmentioning

confidence: 99%

Phytochemical Analysis and Antibacterial Activities of Tamarix dioica Extracts

Bughio

2021

Pak J Anal Environ Chem

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The objective of this study was to investigate the impact of phytochemical analysis and the antibacterial activity of extracts of stem, flowers and leaves of Tamarix dioica Roxb. ex Roth. Four solvents namely, diethyl ether, ethyl acetate, methanol and acetone were selected to obtain extracts from different parts of the plant. The organic solvent extracts were investigated for phytochemical analysis and antibacterial activity against two bacterial strains, namely Escherichia coli and Staphylococcus aureus. The result of phytochemicals revealed the presence of various constituents, such as phlobatannins, tannins, saponins, alkaloids, phenols, proteins, terpenoids, flavonoids and steroids by using standard procedures. Most of these components were present in methanol and ethyl acetate extract. Therefore, four out of two extracts, such as methanol and ethyl acetate extracts from stems, flowers, and leaves, were used to test their evidence of antibacterial activity. From this, it was observed that the methanol extracts of stem, flowers and leaves of T. dioica were highly effective together with E. coli and S. aureus with a minimum inhibitory concentration (MIC) value of 500 μg/mL. Considering that the ethyl acetate (EA) extracts from the stem, flowers and leaves of T. dioica were examined to be ineffective against E. coli and S. aureus and MIC values were not observed in two strains of bacteria.

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“…The use of calixarenes as cation-releasing platforms was investigated by Memon and colleagues, who used a diamide calixarene derivative, 47 ( Figure 10), to complex iron(III) [35] and copper(II) [36]. Iron(III) was found to bind in a 1:1 ratio to the calixarene by a spectroscopic Job's plot and copper(II) in a 2:1 ratio by the same method.…”

Section: Metal-binding Calixarenesmentioning

confidence: 99%

Antimicrobial Activity of Calixarenes and Related Macrocycles

et al. 2020

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Calixarenes and related macrocycles have been shown to have antimicrobial effects since the 1950s. This review highlights the antimicrobial properties of almost 200 calixarenes, resorcinarenes, and pillararenes acting as prodrugs, drug delivery agents, and inhibitors of biofilm formation. A particularly important development in recent years has been the use of macrocycles with substituents terminating in sugars as biofilm inhibitors through their interactions with lectins. Although many examples exist where calixarenes encapsulate, or incorporate, antimicrobial drugs, one of the main factors to emerge is the ability of functionalized macrocycles to engage in multivalent interactions with proteins, and thus inhibit cellular aggregation.

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Synthesis, Characterization, and Exploration of Antimicrobial Activity of Copper Complex of Diamide Derivative of p-tert-butylcalix[4]arene

Cited by 8 publications

References 13 publications

Antifungal Activity of Cymbopogon flexuosus Essential Oil and its Effect on Biofilm Formed by Candida parapsilosis and Candida tropicalis on Polystyrene and Polyvinyl Plastic Surfaces

Antifungal Activity of Cymbopogon flexuosus Essential Oil and its Effect on Biofilm Formed by Candida parapsilosis and Candida tropicalis on Polystyrene and Polyvinyl Plastic Surfaces

Phytochemical Analysis and Antibacterial Activities of Tamarix dioica Extracts

Antimicrobial Activity of Calixarenes and Related Macrocycles

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