Synthesis, characterization, and evaluation of a superficially porous particle with unique, elongated pore channels normal to the surface

Wei, Ta-Chen; Mack, Anne; Chen, Wu; Liu, Jia; Dittmann, Monika; Wang, Xiaoli; Barber, William E.

doi:10.1016/j.chroma.2016.02.018

Cited by 32 publications

(26 citation statements)

References 35 publications

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“…This PMT technology produces straight, unconnected, and radially-oriented mesopores (ROMs) ( Figure 5.). SPP particles with ROMs possess many advantages such as a narrower particle size distribution, thinner porous layer with high surface area and -most importantly -highly ordered, non-tortuous pore channels oriented perpendicular to the particle surface [62]. The improved efficiency of such ROMs mostly related to a smaller B-term probably due to the thinner porous layer and/or the unique, ordered porous straight channels.…”

Section: Radially Oriented Mesopores (Rom-spp)mentioning

confidence: 99%

New developments and possibilities of wide-pore superficially porous particle technology applied for the liquid chromatographic analysis of therapeutic proteins

Bobály

Veuthey

Guillarme

et al. 2018

Journal of Pharmaceutical and Biomedical Analysis

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This review paper discusses the success of columns packed with superficially porous particles (SPP) in liquid chromatography for the analysis of peptides and proteins. First, it summarizes the history of SPP, including the development of different SPP generations from particles of 50 μm to sub-2 μm. It also critically discusses the improved kinetic performance of SPP particles in comparison to fully porous particles. The current trends and applications of columns packed with SPPs for the analysis of peptides and proteins (including mAbs and ADC at the intact and sub-unit levels) are shown, as well. Finally, some of the potential perspectives for this technology are also described, including the radially oriented mesopores or the applicability of the technology for chiral separations.

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Section: Radially Oriented Mesopores (Rom-spp)mentioning

confidence: 99%

New developments and possibilities of wide-pore superficially porous particle technology applied for the liquid chromatographic analysis of therapeutic proteins

Bobály

Veuthey

Guillarme

et al. 2018

Journal of Pharmaceutical and Biomedical Analysis

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“…The red line/curve illustrates the differences in pore structures and diffusion pathways. Reprinted with permission from …”

Section: Fabrication Of Core–shell Particles For Separationsmentioning

confidence: 99%

“…The red line/curve illustrates the differences in pore structures and diffusion pathways. Reprinted with permission from [146] The particles were functionalised with a C18 bonding and packed into a column showing separation performance as high as 2.25 × 105 plates/m for naphthalene and backpressure as low as 5.8 MPa. The columns were not evaluated for reduced parameters or kinetic performance.…”

Section: F I G U R E 8 High-resolution Sem Comparison Between (A) Pmtmentioning

confidence: 99%

Core–shell microspheres with porous nanostructured shells for liquid chromatography

Ahmed

Skinley

Herodotou

et al. 2017

J of Separation Science

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The development of new stationary phases has been the key aspect for fast and efficient high-performance liquid chromatography separation with relatively low backpressure.Core-shell particles, with a solid core and porous shell, have been extensively investigated and commercially manufactured in the last decade. The excellent performance of core-shell particles columns has been recorded for a wide range of analytes, covering small and large molecules, neutral and ionic (acidic and basic), biomolecules and metabolites. In this review, we first introduce the advance and advantages of coreshell particles (or more widely known as superficially porous particles) against nonporous particles and fully porous particles. This is followed by the detailed description of various methods used to fabricate core-shell particles. We then discuss the applications of common silica core-shell particles (mostly commercially manufactured), spheres-on-sphere particles and core-shell particles with a non-silica shell. This review concludes with a summary and perspective on the development of stationary phase materials for high-performance liquid chromatography applications.

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“…Growing porous silica gels or whiskers on the surface of nonporous core silica gels [108][109][110][111][112][113][114][115][116][117][118][119][120][121]: Many synthesis methods are focused on growing porous silica gels or silica whiskers on the surface of nonporous core silica gels. However, the reaction methods used to do this are similar and based on polymerizing organic silicones such as tetraethoxysilicone and tetramethoxysilicone in solutions containing cationic surfactants.…”

mentioning

confidence: 99%

“…However, the reaction methods used to do this are similar and based on polymerizing organic silicones such as tetraethoxysilicone and tetramethoxysilicone in solutions containing cationic surfactants. The selection of additives and different physical conditions produced a variety of SPPs [108][109][110][111][112][113][114][115][116][117][118][119].…”

mentioning

confidence: 99%

Fundamental Properties of Packing Materials for Liquid Chromatography

Hanai¹

2019

Separations

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The high performance of chemically-modified silica gel packing materials is based on the utilization of pure silica gels. Earlier silica gels used to be made from inorganic silica; however, nowadays, silica gels are made from organic silanes. The surface smoothness and lack of trace metals of new silica gels permits easy surface modifications (chemical reactions) and improves the reproducibility and stability. Sharpening peak symmetry is based on developing better surface modification methods (silylation). Typical examples can be found in the chromatography of amitriptyline for silanol testing and that of quinizarin for trace metal testing. These test compounds were selected and demonstrated sensitive results in the measurement of trace amounts of either silanol or trace metals. Here, we demonstrate the three-dimensional model chemical structures of bonded-phase silica gels with surface electron density for easy understanding of the molecular interaction sites with analytes. Furthermore, a quantitative explanation of hydrophilic and hydrophobic liquid chromatographies was provided. The synthesis methods of superficially porous silica gels and their modified products were introduced.

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Synthesis, characterization, and evaluation of a superficially porous particle with unique, elongated pore channels normal to the surface

Cited by 32 publications

References 35 publications

New developments and possibilities of wide-pore superficially porous particle technology applied for the liquid chromatographic analysis of therapeutic proteins

New developments and possibilities of wide-pore superficially porous particle technology applied for the liquid chromatographic analysis of therapeutic proteins

Core–shell microspheres with porous nanostructured shells for liquid chromatography

Fundamental Properties of Packing Materials for Liquid Chromatography

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