Synthesis, characterization and evaluation of retinoic acid-polyethylene glycol nanoassembly as efficient drug delivery system

Nagar, Prachi; Goyal, Preeti; Gupta, Atul; Sharma, Ashwani; Kumar, Pradeep

doi:10.1016/j.nanoso.2018.01.016

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…Retinoic acid (RA) binds to the heterodimers of the retinoic acid receptor (RARs) and the retinoid X receptor (RXRs) present in the nuclear membrane of cancer cells, which leads to growth inhibition, differentiation, or apoptosis in these cells. Studies have shown that, when used in combination with chemotherapeutic agents such as OXA, those characteristics of RA lead to increased cytotoxicity and decreased side effects via synergistic action of therapeutic agents [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer

et al. 2020

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Apoptosis signaling pathways, drug resistance, and metastasis are important targets to develop new cancer treatments. We developed cholesterol-coated Poly(d,l-Lactide-co-Glycolic Acid) (PLGA) nanoparticles for effective encapsulation and delivery of retinoic acid and oxaliplatin to analyze their antitumor activity in colorectal cancer. The cell viability and proliferation of tumoral cells lines (CT-26 and SW-480) decreased when compared to control in vitro after treatment with the nanoparticles. In addition, apoptosis of CT-26 cells increased. Importantly, cytoprotection of nontumor cells was detected. Expression of pro-apoptotic proteins was upregulated, while anti-apoptotic proteins were downregulated either in vitro or in vivo. In addition, drug resistance and metastasis factors were downregulated in vivo. Human colorectal tumors that highly expressed BCL-2 and Ki-67 had a greater tendency towards death within 60 months. Our results show that loading oxaliplatin combined with retinoic acid and cholesterol in a nanoparticle formulation enables determination of optimal antitumor activity and subsequent treatment efficacy.

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Section: Introductionmentioning

confidence: 99%

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer

et al. 2020

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“…Biomaterials are often based on natural polysaccharides [129,130,131,132,133]. Among polysaccharides, Alginates have found applications in the food sector, water purification, biomedicine and packaging [73,134,135,136,137,138,139]. Algae contain nutrients such as vitamins, salts, iodine and sterols.…”

Section: Biopolymers For Biomedical and Pharmaceutical Packagingmentioning

confidence: 99%

Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning

et al. 2019

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Innovative solutions using biopolymer-based materials made of several constituents seems to be particularly attractive for packaging in biomedical and pharmaceutical applications. In this direction, some progress has been made in extending use of the electrospinning process towards fiber formation based on biopolymers and organic compounds for the preparation of novel packaging materials. Electrospinning can be used to create nanofiber mats characterized by high purity of the material, which can be used to create active and modern biomedical and pharmaceutical packaging. Intelligent medical and biomedical packaging with the use of polymers is a broadly and rapidly growing field of interest for industries and academia. Among various polymers, alginate has found many applications in the food sector, biomedicine, and packaging. For example, in drug delivery systems, a mesh made of nanofibres produced by the electrospinning method is highly desired. Electrospinning for biomedicine is based on the use of biopolymers and natural substances, along with the combination of drugs (such as naproxen, sulfikoxazol) and essential oils with antibacterial properties (such as tocopherol, eugenol). This is a striking method due to the ability of producing nanoscale materials and structures of exceptional quality, allowing the substances to be encapsulated and the drugs/ biologically active substances placed on polymer nanofibers. So, in this article we briefly summarize the recent advances on electrospinning of biopolymers with particular emphasis on usage of Alginate for biomedical and pharmaceutical applications.

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“…[ 11–17 ] More recently, great effort has been put into the development of multifunctional block copolymer micelles with improved properties such as enhanced drug loading efficiency and stimuli‐responsive capacity to pH, temperature, light, etc. [ 18–24 ] Especially, pH‐responsive systems are highly desirable in order to exploit pH gradients in biological compartments such lysosomes (pH 4.5–5.0) or cancer cells. [ 25–27 ]…”

Section: Introductionmentioning

confidence: 99%

pH‐Responsive Micelle‐Forming Amphiphilic Triblock Copolymers

Bener

Puglisi

Yaǧcı

2020

Macro Chemistry & Physics

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A novel pH‐responsive micellar nanoparticle based on poly(ethylene glycol)–polydimethylsiloxane–poly(ethylene glycol) triblock copolymer with benzoic imine linkage is reported. A new synthetic approach to produce the pH‐cleavable polymer that can self‐assemble into stable micellar nanoparticle is presented. Such nanoparticles are stable at physiological pH, but degrade at slightly acidic pH, making this system potentially suitable to exploit pH gradients in biological compartments. The precursors, intermediates, final polymers, and micellar nanoparticles are characterized in detail by various spectroscopic techniques, gel permeation chromatography, and particle size measurements.

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Synthesis, characterization and evaluation of retinoic acid-polyethylene glycol nanoassembly as efficient drug delivery system

Cited by 10 publications

References 43 publications

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer

Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer

Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning

pH‐Responsive Micelle‐Forming Amphiphilic Triblock Copolymers

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