Synthesis, characterization and evaluation of antioxidant properties of catechin hydrate nanoparticles

Kaur, Ramneek; Rajput, Rashi; Nag, Payal; Kumar, Sachin; Rachana,; Singh, Manisha

doi:10.1016/j.jddst.2017.04.030

Cited by 29 publications

(15 citation statements)

References 32 publications

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“…In another study, Kaur et al [94] formulated catechin hydrate (CH)-loaded nanoparticles by ionic gelation method by drop wise infusing the anionic polymer (tripolyphosphate) into drug loaded polymeric cationic solution of chitosan, finally leading to the three-dimensional lattice formation. Catechin loaded nanoparticles (CHNPs) showed higher DPPH (67.01 ± 0.15%) scavenging activity as compared to pure CH (65.69 ± 0.34%), similarly better anti-radical and scavenging activity of nitric oxide (NO) (46.12 ± 0.11%) and H 2 O 2 (36.31 ± 0.31%)) as compared to pure CH (NO scavenging = 42.31 ± 0.14% and H 2 O 2 scavenging = 38.12 ± 0.11%).…”

Section: Chitosan Originated Nanocarriermentioning

confidence: 99%

“…This improved antioxidant activity dictates the greater efficiency and therapeutic index of encapsulated CH. Moreover, the encapsulation process ensures the slow release of CHNPs (83%, 12 h) with sustainability until 12 h and less cytotoxicity than CH [94]. Chlorogenic acid (CGA), another polyphenolic antioxidant, was encapsulated into chitosan nanoparticles by ionic gelation method, and ensures that the free radical scavenging activity of CGA was restrained and the antioxidant activity of CGA (IC50 value 92 ± 5 µg/mL) is better than unencapsulated CGA (IC50: 89 ± 3 µg/mL) [95].…”

Section: Chitosan Originated Nanocarriermentioning

confidence: 99%

“…CH and some other well-known polyphenols, secondary metabolites in plants, have potential therapeutic properties, but are limited by their low oral bioavailability, poor stability, and intestinal absorption, forced to think about the development of targeted nanoparticle-based carrier system to overcome the physicochemical limitations and increase its stability, bioaccessibility, and control release of the active phenolic phytochemicals [74,94]. In this aspect, four polyphenols: (+)-catechin, (−)-epicatechin, (−)-epigallocatechin-3-gallate, and proanthocyanidins, were loaded with biocompatible starch nanoparticles (SNPs) and antioxidant potentiality was investigated under different conditions of ionic strength, high temperature, and ultraviolet radiation.…”

Section: Starch Nanoparticlesmentioning

confidence: 99%

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Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

et al. 2019

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Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

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Section: Chitosan Originated Nanocarriermentioning

confidence: 99%

Section: Chitosan Originated Nanocarriermentioning

confidence: 99%

Section: Starch Nanoparticlesmentioning

confidence: 99%

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Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

et al. 2019

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“…Further, graphical representation of the estimated and recorded entrapment efficiency of HCTZ nanocoacervates (Figure 3) showed the correlation between all the optimized parameters and hence, confirms the successful preparation of HCTZ loaded nanocoacervates. 21…”

Section: Resultsmentioning

confidence: 99%

Bio Pharmaceutics Classification System (BCS) Class IV Drug Nanoparticles: Quantum Leap to Improve Their Therapeutic Index

et al. 2018

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Purpose: Biopharmaceutics classification system (BCS) class IV compounds, exhibits least oral bioavailability, low solubility and intestinal permeability among all pharmaceutical classes of drugs. Thus, these drugs need more compatible and efficient delivery system. Since, their solubility in various medium, remains a limitation so, polymeric nano coacervates based drug loading with modified approach for them may prove to be a solution ahead. Therefore, in present study Chitosan is opted for encapsulating the BCS class IV drug (Hydrochlorothiazide) to attain better stability, enhanced permeability and lower toxicity.Methods: For this study, Hydrochlorothiazide (HCTZ) was opted for formulating chitosan based nano-coacervate system.Results: Optimized HCTZ nanocoacervates exhibited the average particle size of 91.39 ± 0.75 nm with Poly-dispersity index score of 0.159 ± 0.01, indicating homogeneity of colloidal solution. Zeta potential and encapsulation efficiency of HCTZ nanocoacervates were recorded as -18.9 ± 0.8 mV and 76.69 ± 0.82 % respectively. Further, from TEM and SEM evaluation the average particle size for the same were found in conformity (35-50 nm), with almost spherical morphology. Also, the EDX (Electron Dispersive X-ray) spectrometry and FT – IR analysis of optimized formulation indicated the balanced chemical composition and interaction between the polymeric molecules. The HCTZ nano coacervates showed the linear diffusion profile through the dialysis membrane.Conclusion: We can conclude from the present study that the optimized HCTZ nano coacervates may prove to be a suitable potential option for effective delivery of BCS class IV drugs.

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“…We revealed that P. brachycarpa accumulate some phenolic compounds, especially catechin hydrate was highly accumulated in leaves. Many previous reports revealed that catechin hydrate have effect on antioxidant (Mehra et al, 2013;Harper et al, 2010;Kaur et al, 2017;Kassim et al, 2011;Jing et al, 2018;Samanta et al, 2016). In addition to, other report revealed that catechin hydrate has effect on anti-inflammatory (Ashafaq et al, 2012), anti-cancer (Alshatwi, 2010) and improvement of cognitive impairment (Ahmed et al, 2013).…”

Section: Variation In Level Of Phenolic Compounds In the Roots Of P mentioning

confidence: 97%

Content of Phenolic Compounds of Different Organ in Pimpinella brachycarpa Collected from Different Locations in Korea

Kim

Jung

Jeon

et al. 2020

OnLine Journal of Biological Sciences

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Pimpinella brachycarpa (Kom.) Nakai, reported to have antioxidant activity, is one of the most favored edible greens grown in Asian regions. The present study explores the variation in phenolic compounds in P. brachycarpa collected from different locations in Korea. Six phenolic compounds, i.e., catechin hydrate, chlorogenic acid, ferulic acid, benzoic acid, rutin and quercetin, were detected in the leaves, whereas among these compounds ferulic acid and quercetin were absent in the stems and benzoic acid and quercetin were absent in the roots of P. brachycarpa. The variation in phenolic compounds in plants from different locations was not as much as that among the different parts. The level of catechin hydrate content was much higher in the leaves than in the stems and roots. The amount of catechin hydrate in the leaves was 8.03 and 6.63 times higher than that of the highest catechin hydrate content in the roots and stems, respectively. The amount of benzoic acid accumulated was slightly higher (1.39 times) in the stems than the highest level in the leaves. The amount of ferulic acid accumulated was 1.9 times higher in the roots than the maximum level in the leaves. The amount of rutin accumulated was 1.91 times higher and 1.32 times lower in the roots than the highest levels in the stems and leaves, respectively. Our results indicate that phenolic compounds in P. brachycarpa varied significantly among the organs from different locations and the highest amount of phenolic compounds is contained in the leaves.

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Synthesis, characterization and evaluation of antioxidant properties of catechin hydrate nanoparticles

Cited by 29 publications

References 32 publications

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

Bio Pharmaceutics Classification System (BCS) Class IV Drug Nanoparticles: Quantum Leap to Improve Their Therapeutic Index

Content of Phenolic Compounds of Different Organ in Pimpinella brachycarpa Collected from Different Locations in Korea

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