Synthesis, characterization and evaluation cytotoxic activity of silver nanoparticles synthesized by Chinese herbal Cornus officinalis via environment friendly approach

He, Yangqing; Li, Xing; Wang, Ju; Yang, Qian; Yao, Binghua; Zhao, Yiming; Zhao, Aiming; Sun, Wenxing; Zhang, Qian

doi:10.1016/j.etap.2017.08.035

Cited by 47 publications

(27 citation statements)

References 19 publications

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“…The bands appearing at 2933, 1560 and 1383 and 1078 cm −1 indicate the presence of different functional groups and were assigned to C-H stretching vibration, C=C stretching vibration from aromatic rings and C-O stretching or O-H deformation vibration, respectively [ 34 ]. Most of the IR bands probably arise from the flavonoids anthocyanins and phenolic compounds from the fruit extract, indicating that the phytosynthesized AgNPs were stabilized by these biomolecules [ 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

et al. 2018

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The present study reports for the first time the efficacy of bioactive compounds from Ligustrum ovalifolium L. fruit extract as reducing and capping agents of silver nanoparticles (AgNPs), developing a green, zero energetic, cost effective and simple synthesis method of AgNPs. The obtained nanoparticles were characterized by UV-Vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier Transform Infrared spectroscopy (FTIR), confirming that nanoparticles were crystalline in nature, spherical in shape, with an average size of 7 nm. The FTIR spectroscopy analysis demonstrated that the AgNPs were capped and stabilized by bioactive molecules from the fruit extract. The cytotoxicity of the biosynthesized AgNPs was in vitro evaluated against ovarian carcinoma cells and there were found to be effective at low concentration levels.

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Section: Resultsmentioning

confidence: 99%

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

et al. 2018

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“…Normally, scientific works involving the synthesis of AgNPs, contain a thorough characterization of the nanomaterials by these techniques, TEM, DLS, and UV-Vis spectrophotometry. For example, He et al [46] synthesized AgNPs through an eco-friendly approach, using the fruit aqueous extract of Chinese herbal Cornus officinalis. The as-synthesized AgNPs showed a λ max of 411 nm, the DLS spectrum indicated a narrow distribution of the nanoparticles with a diameter of 12.8 ± 3.5 nm, while the TEM analysis revealed that the nanoparticles presented a quasi-spherical shape, and the particle size was 11.7 nm, close to the obtained DLS value.…”

Section: Characterization Methodsmentioning

confidence: 99%

Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

2021

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Since the last decade, nanotechnology has evolved rapidly and has been applied in several areas, such as medicine, pharmaceutical, microelectronics, aerospace, food industries, among others. The use of nanoparticles as drug carriers has been explored and presents several advantages, such as controlled and targeted release of loaded or coupled drugs, and the improvement of the drug’s bioavailability, in addition to others. However, they also have some limitations, related to their in vivo toxicity, which affects all organs including the healthy ones, and overall improvement in the disease treatment, which can be unnoticeable or minimal. Silver nanoparticles have been increasingly investigated due to their peculiar physical, chemical, and optical properties, which allows them to cover several applications, namely in the transport of drugs to a specific target in the body. Given the limitations of conventional cancer chemotherapy, which include low bioavailability and the consequent use of high doses that cause adverse effects, strategies that overcome these difficulties are extremely important. This review embraces an overview and presentation about silver nanoparticles used as anticancer drug carrier systems and focuses a discussion on the state of the art of silver nanoparticles exploited for transport of anticancer drugs and their influence on antitumor effects.

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“…The same research group evaluated the preventive effects of nanoencapsulated pelargonidin against alloxan-induced DNA damaged cells (L6) by in vitro methods, and reported around ~10-fold enhancement in efficacy of nanoencapsulated pelargonidin than pelargonidin (Samadder et al, 2016). Extracts of Chinese herbal medicine named “Shanzhuyu” containing ANTs were also used for the preparation of metal nanoparticles, and unveiled promising anticancer activity against human liver cancer (HepG2) and human prostate cancer (PC-3) cell lines (He et al, 2006, 2017). Apart from the nanoformulations and encapsulation, nano packing is also considered an emerging technique for the preservation of quality in ANT-rich fruits like strawberries (Yang et al, 2010).…”

Section: Role Of Nanoformulation and Encapsulation Methods In Anthocymentioning

confidence: 99%

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

et al. 2018

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The term “metabolic syndrome” (MetS) refers to a combination of diabetes, high blood pressure, and obesity. The origin of MetS includes a combination of multiple factors, such as sedentary lifestyle, unhealthy diet choice, and genetic factors. MetS is highly prevalent and adversely affects the general population by elevating risk of cardiovascular complications, organ failure, and much other pathology associated with late-stage diabetes. Anthocyanins (ANTs) are health-promoting bioactive compounds belonging to the flavonoids subclass of polyphenols. Numerous studies have reported the potential therapeutic benefits on MetS syndrome and diabetes from fruits rich in ANTs. This review summarizes the role of several dietary ANTs on preventing and managing MetS as well as the pharmacological mechanisms and biopharmaceutical features of their action. We also discuss potential nanoformulation and encapsulation approaches that may enhance the bioefficacy of ANTs in MetS. Experiments have demonstrated that ANTs may attenuate the symptoms of MetS via improving insulin resistance, impaired glucose tolerance, dyslipidaemia, cholesterol levels, hypertension, blood glucose, protecting β cells, and preventing free radical production. In brief, the intake of ANT-rich supplements should be considered due to their plausible ability for prevention and management of MetS. Additionally, randomized double-blind clinical trials are obligatory for evaluating the bioefficacy and pharmacological mechanisms of ANTs and their pharmaceutical formulations in patients with MetS.

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Synthesis, characterization and evaluation cytotoxic activity of silver nanoparticles synthesized by Chinese herbal Cornus officinalis via environment friendly approach

Cited by 47 publications

References 19 publications

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

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