Synthesis, Characterization and Drug Release Capability of New Cost Effective Mesoporous Silica Nano Particle for Ibuprofen Drug Delivery

Ganesh, Mani; Lee, Seung Gil

doi:10.14257/ijca.2013.6.5.20

Cited by 23 publications

(11 citation statements)

References 22 publications

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“…However, the tablet formulation showed controllable up curving release characteristics with 90% of GCV released over 8 h. These results could be explained owing to the highly porous nature of the lyomatrix compared to the compact nature of the traditional tablets (Fig. 3d) and as reported previously (36)(37)(38)(39)(40)(41)(42). It is also highlighted that PAA is a highly super absorbent polymer.…”

Section: In Vitro Drug Release Studiessupporting

confidence: 70%

Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix

et al. 2015

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Abstract. A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concentrations in order to compare the GCV release behavior from the lyomatrix and tablets. GCV incorporation (75.12%) was confirmed using FTIR, DSC, and TGA. The effect of GCV loading on the microstructure properties of the lyomatrix was evaluated by SEM, AFM, and BET surface area measurements. The in vitro drug release study showed steady and rapid release profiles from the GCV-loaded lyomatrix compared with the tablet formulation at identical pH values. Minimum GCV release was observed at acidic pH (≤40%) and maximum release occurred at intestinal pH values (≥90%) proving the intestinal targeting ability of the lyomatrix. Kinetic modeling revealed that the GCV-loaded lyomatrix exhibited zero-order release kinetics (n=1), while the tablets were best described via the Peppas model. Textural analysis highlighted enhanced matrix resilience and rigidity gradient (12.5%, 20 Pa) for the GCV-loaded lyomatrix compared to the pure (7%, 9.5 Pa) HEC-PAA lyomatrix. Bench-top MRI imaging was used to confirm the mechanism of GCV release behavior by monitoring the swelling and erosion rates. The swelling and erosion rate of the tablets was not sufficient to achieve rapid zero-order GCV release as with the lyomatrix. These combined results suggest that the HEC-PAA lyomatrix may be suitable for GCV intestinal targeting after oral administration.

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Section: In Vitro Drug Release Studiessupporting

confidence: 70%

Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix

et al. 2015

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“…Several drugs with low water solubility have been explored to demonstrate this concept including ibuprofen, rifampin, etc. (Zhang et al 2010;Mohseni et al 2015;Ganesh and Lee 2013). Based on non-toxicity and biocompatibility, silica nanoparticles are proposed as alternative carriers for drug delivery as these can be degraded into its simple silanol units and can be removed from the body (Fent et al 2010;Yu et al 2009;Liu et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

et al. 2017

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Monastrol is a simple low molecular weight dihydropyrimidine-based kinesin Eg5 inhibitor. Its low cellular activity and its non-drug-like properties have impeded its further development. In a previous report, we have reported various topological parameters to improve the pharmacokinetic properties of monastrol. The purpose of this study is to determine the loading and release feasibility of poorly water-soluble monastrol into the synthesized mesoporous silica nanoparticles (MSNs). The synthesis of MSNs was attained by the ammonia-catalysed hydrolysis and condensation of TEOS in ethanol using polysorbate-80 as surfactant. These were characterized by BET surface area and pore size distribution analyses, SEM, XRD, UV and FTIR spectroscopy. The synthesized monastrol was successfully loaded on MSNPs and coated by hydrogels for successful controlled drug delivery. In vitro release studies are done by simple dialysis method.Monastrol-loaded MSNPs were tested on human cervical epithelial malignant carcinoma (HeLa) cell lines for studying their anticancer activity. Our presented system described a reliable method for targeted delivery of monastrol into the cancer cells in vitro.

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“…As shown in Figure B, the ReSiN lost about 55% weight at 700 °C, which could be attributed to the breakdown of the carbon-disulfide network derived from APTMS and DTSP. Because of the high carbon content in the ReSiN, the weight loss of the ReSiN in TGA is much higher than in mesoporous silica nanoparticles. , Approximately 5.4% of the weight decrease could be due to TAMRA modification of the ReSiN surface. Additionally, a dramatic drop in weight was observed upon BSA adsorption.…”

Section: Resultsmentioning

confidence: 99%

Plant Cell Wall-Penetrable, Redox-Responsive Silica Nanoprobe for the Imaging of Starvation-Induced Vesicle Trafficking

et al. 2016

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Autophagy is a self-protection process against reactive oxygen species (ROS). The intracellular level of ROS increased when cells were cultured under nutrient starvation. Antioxidants such as glutathione and ascorbic acid play an important role in ROS removal. However, the cellular redox state in the autophagic pathway is still unclear. Herein, we developed a new redox-sensitive probe with a disulfide-linked silica scaffold to enable the sensing of the reduction environment in cell organelles. This redox-responsive silica nanoprobe (ReSiN) could penetrate the plant cell wall and release fluorescent molecules in response to redox states. By applying the ReSiN to tobacco BY-2 cells and tracing the distribution of fluorescence, we found a higher reducing potential in the central vacuole than in the autolysosomes. Upon cysteine protease inhibitor (E64-c) treatment in sucrose-free medium, the disulfide-silica structures of the ReSiNs were broken down in the vacuoles but were not degraded and were accumulated in the autolysosomes. These results reveal the feasibility of our nanoprobe for monitoring the endocytic and macroautophagic pathways. These pathways merge upstream of the central vacuole, which is the final destination of both pathways. In addition, different redox potentials were observed in the autophagic pathway. Finally, the expression of the autophagy-related protein (Atg8) fused with green fluorescence protein confirmed that the ReSiN treatment itself did not induce the autophagic pathway under normal physiological conditions, indicating the versatility of this nanoprobe in studying stimuli-triggered autophagy-related trafficking.

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Synthesis, Characterization and Drug Release Capability of New Cost Effective Mesoporous Silica Nano Particle for Ibuprofen Drug Delivery

Abstract: New mesoporous silica nanoparticle (MSNs)

Cited by 23 publications

References 22 publications

Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix

Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix

Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

Plant Cell Wall-Penetrable, Redox-Responsive Silica Nanoprobe for the Imaging of Starvation-Induced Vesicle Trafficking

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