Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard–soft NS donor ligand

Abstract

Knoevenagel condensate-based Schiff base ligands (L) containing N and S donor sites have been designed and synthesized [L ¼ 3-cinnamalideneacetylacetonethiosemicarbazone (CAT)/ 3-cinnamalideneacetylacetoneethylthiosemicarbazone (CAET)/3-cinnamalideneacetylacetonephenylthiosemicarbazone (CAPT)]. They afford complexes of the type [ML] [M ¼ Cu(II) and Zn(II)]. Both the ligands and their complexes were characterized by analytical and spectral data. Intercalative binding of these complexes with DNA has been investigated by electronic absorption spectroscopy, viscosity measurements, cyclic voltammetry, and differential pulse voltammetry. Electrophoretic study of the complexes indicates that they efficiently cleave supercoiled pUC19 DNA in the presence of hydrogen peroxide.

Synthesis and crystal structure of new dicopper(II) complexes having asymmetric N,N′-bis(substituted)oxamides with DNA/protein binding ability: In vitro anticancer activity and molecular docking studies

“…4, the binding constants (K b ) for complexes 1 and 2 were estimated to be (7.23 ± 0.12) Â 10 4 (R = 0.9921 for six points) and (1.21 ± 0.02) Â 10 4 M À1 (R = 0.9933 for six points), respectively. All the K b values of the present dicopper(II) complexes are lower than those observed for a classical intercalator such as EB ($10 6 M À1 ) [52,53], and have the same level as those of some well-established intercalation agents [54,55], indicating that the present dicopper(II) complexes can strongly bind to HS-DNA, and this may be related to their structural characteristics. It is noteworthy that the K b value of the complex 1 is about six fold higher than that of the complex 2.…”

Biological Screening Studies of DNA Relate Metal Complexes from Benzylidene-4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one and 2-aminothiazole

“…The SEM image of the complexes confirms the presence of ligands in the metalchelates. Hence, the metal ion affects the morphology of Schiff base in the metal-chelates [28][29][30].…”

Synthesis, structure, cytotoxic activities and DNA-binding properties of tetracopper(II) complexes with dissymmetrical N,N′-bis(substituted)oxamides as ligands

“…Along this line, lots of copper(II) complexes, which possess biologically accessible redox potentials and demonstrate high nucleobase affinity, have been synthesized and their interactions with DNA extensively studied [12][13][14][15][16][17][18][19][20][21][22]. Compared to the number of studies dealing with mono-and binuclear complexes [23][24][25][26][27][28][29][30], relatively few studies on tetranuclear complexes have been reported [31][32][33][34][35]. However, the enhancement of DNA-binding activity for tetranuclear complexes [31][32][33][34][35] stimulates us to design and synthesize new tetranuclear complexes to evaluate DNA-binding properties and in vitro antitumor activities.…”