Synthesis, characterization and DNA binding studies of organoantimony(V) ferrocenyl benzoates

Coordination compounds in cancer: Past, present and perspectives

“…Sodium stibogluconate (SSG) is used as drug to treat leishmaniasis but recently, its synergistic effect with IFN-a to overcome IFN-a resistance in various human cancer cell lines was demonstrated (Yi et al, 2002). Complexes of antimony(V) shows 10-fold lower toxicity than the corresponding antimony(III) ones (Asghar et al, 2012). Furthermore, ferrocenyl benzoateantimony complexes have been shown to be promising chemotherapeutic compounds (Liu et al, 2003;Li et al, 2004;Yu et al, 2004) but their mechanism of action is not yet known.…”

Electrochemical, spectroscopic, and theoretical studies on the interaction between azathioprine and DNA

“…The diffusion-control behavior was evident from the linear plot of the voltammetric response as a function of ν 1/2 . From the slope of the obtained line, diffusion coefficient for free AZT (D f ) was calculated as 5.86× 10 -5 cm 2 s -1 , whereas for the AZT-DNA complex, D b was reduced to 2.90 × 10 -5 cm 2 s -1 .The negative shift in potential of C 1 during successive additions of DNA, confirms the nonintercalative nature of the interaction, indeed it refers to electrostatic interactions with DNA[21,[25][26][27][28].…”

Synthesis, structural characterization, DNA binding and antioxidant potency of new ferrocene incorporated acyl ureas

“…interactions with DNA then we will be able to control the cancer [1]. Cisplatin is a potent antineoplastic agent but has some negative side effects.…”