Synthesis, Characterization, and Cytotoxicity of Fe3O4@Ag Hybrid Nanoparticles: Promising Applications in Cancer Treatment

Pieretti, Joana C.; Rolim, Wallace R.; Ferreira, Fábio Furlan; Lombello, Christiane Bertachini; Nascimento, Mônica Helena Monteiro do; Seabra, Amedea B.

doi:10.1007/s10876-019-01670-0

Cited by 21 publications

(14 citation statements)

References 76 publications

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“…The prepared NPs were characterized, as described herein. The structure of the uncoated Fe 3 O 4 @Ag NPs was previously confirmed, evidencing the formation of a structure composed of 87% of Fe 3 O 4 NPs and 13% of AgNPs through XRD analyses, which was maintained in Fe 3 O 4 @Ag/TCS NPs [23]. The presence of AgNPs and Fe 3 O 4 was also confirmed by XPS, as shown in Fig.…”

Section: Characterization Of Fe 3 O 4 @Ag/tcs Nps and Control Npssupporting

confidence: 56%

“…In this work, we synthesized Fe 3 O 4 NPs by co-precipitation followed by the reduction of Ag + by green tea extract on the surface of Fe 3 O 4 NPs leading to the formation of Fe 3 O 4 @Ag NPs, as previous reported [ 23 , 27 ]. The surface of Fe 3 O 4 @Ag NPs was coated with TCS, by thiolation of CS backbone [ 20 ], leading to the formation of Fe 3 O 4 @Ag/TCS NPs.…”

Section: Resultsmentioning

confidence: 99%

“…Fe 3 O 4 @Ag NPs were prepared through chemical co-precipitation and green tea reduction of Ag + ions, as previously reported [ 23 ]. TCS was prepared by the conjugation of thioglycolic acid in the presence of 1-etil-3-(3-dimethylaminopropyl)carbodiimide [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

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Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility

Pieretti

Gonçalves

Nakazato

et al. 2021

J Mater Sci: Mater Med

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The combination of Fe3O4@Ag superparamagnetic hybrid nanoparticles and nitric oxide (NO) represents an innovative strategy for a localized NO delivery with a simultaneous antibacterial and antitumoral actions. Here, we report the design of Fe3O4@Ag hybrid nanoparticles, coated with a modified and nitrosated chitosan polymer, able to release NO in a biological medium. After their synthesis, physicochemical characterization confirmed the obtention of small NO-functionalized superparamagnetic Fe3O4@Ag NPs. Antibacterial assays demonstrated enhanced effects compared to control. Bacteriostatic effect against Gram-positive strains and bactericidal effect against E. coli were demonstrated. Moreover, NO-functionalized Fe3O4@Ag NPs demonstrated improved ability to reduce cancer cells viability and less cytotoxicity against non-tumoral cells compared to Fe3O4@Ag NPs. These effects were associated to the ability of these NPs act simultaneous as cytotoxic (necrosis inductors) and cytostatic compounds inducing S-phase cell cycle arrest. NPs also demonstrated low hemolysis ratio (<10%) at ideal work range, evidencing their potential for biomedical applications.

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Section: Characterization Of Fe 3 O 4 @Ag/tcs Nps and Control Npssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

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Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility

Pieretti

Gonçalves

Nakazato

et al. 2021

J Mater Sci: Mater Med

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“…The syntheses of Fe 3 O 4 NPs, Fe 3 O 4 @Ag NPs, and Fe 3 O 4 @Ag/TCS NPs were successfully performed through the proposed route, employing green tea extract as a non-toxic reducing agent of silver ions (Ag + ) to metallic silver (Ag NPs) onto the surface of the Fe 3 O 4 magnetic core, as previously described [ 3 ]. We have previously reported that the hybrid NPs presented a mass proportion of 87% of Fe 3 O 4 NPs and 13% of Ag NPs in one stable Fe 3 O 4 @Ag NPs nanostructure [ 3 ]. The surface of the hybrid nanostructure Fe 3 O 4 @Ag NPs was functionalized with TCS, which can be further functionalized.…”

Section: Resultsmentioning

confidence: 99%

“…Considering the increasing progress regarding the engineering of hybrid nanomaterials, combining several NPs in one unique nanostructure induces surface modification, which is also obtained by adding polymers and/or functional, and/or drug-releasing coatings [ 3 , 12 ]. Our group previously demonstrated the antibacterial and antitumoral properties of a hybrid nanostructure based on Fe 3 O 4 , and silver NPs (AgNPs), coated with a modified chitosan polymer, thiolated chitosan (TCS) [ 3 ], which offers a platform for further chemical modifications [ 13 , 14 ]. The goal was to combine the magnetic properties of Fe 3 O 4 NPs with the antimicrobial and the antitumoral effects of AgNPs [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Multiple Functional Layers in the Structure of Magnetic Nanoparticles and Their Influence on Albumin Interaction

Pieretti

Beurton

Munévar

et al. 2021

IJMS

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In nanomedicine, hybrid nanomaterials stand out for providing new insights in both the diagnosis and treatment of several diseases. Once administered, engineered nanoparticles (NPs) interact with biological molecules, and the nature of this interaction might directly interfere with the biological fate and action of the NPs. In this work, we synthesized a hybrid magnetic nanostructure, with antibacterial and antitumoral potential applications, composed of a magnetite core covered by silver NPs, and coated with a modified chitosan polymer. As magnetite NPs readily oxidize to maghemite, we investigated the structural properties of the NPs after addition of the two successive layers using Mössbauer spectroscopy. Then, the structural characteristics of the NPs were correlated to their interaction with albumin, the major blood protein, to evidence the consequences of its binding on NP properties and protein retention. Thermodynamic parameters of the NPs–albumin interaction were determined. We observed that the more stable NPs (coated with modified chitosan) present a lower affinity for albumin in comparison to pure magnetite and magnetite/silver hybrid NPs. Surface properties were key players at the NP–biological interface. To the best of our knowledge, this is the first study that demonstrates a correlation between the structural properties of complex hybrid NPs and their interaction with albumin.

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Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

et al. 2021

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Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME). Therefore, combination therapy involving additional therapeutics is often necessary and the resulting complication may jeopardize the practical feasibility. Herein, an unprecedented “all‐in‐one” Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal therapy with guidance by magnetic resonance, photoacoustic, and photothermal imaging. Based on its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) and photodynamic property, cascaded nanocatalytic reactions are enabled and sustained in TME for outstanding therapeutic outcomes. The working mechanisms underlying the intraparticulate interactions, sustainability, and self‐replenishment arising from the coupling between the nanocatalytic reactions and nanozyme activities are carefully revealed, providing new insights into the design of novel nanozymes for nanocatalytic therapy with high efficiency, good specificity, and low side effects.

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Synthesis, Characterization, and Cytotoxicity of Fe3O4@Ag Hybrid Nanoparticles: Promising Applications in Cancer Treatment

Cited by 21 publications

References 76 publications

Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility

Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility

The Impact of Multiple Functional Layers in the Structure of Magnetic Nanoparticles and Their Influence on Albumin Interaction

Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

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Synthesis, Characterization, and Cytotoxicity of Fe3O4@Ag Hybrid Nanoparticles: Promising Applications in Cancer Treatment

Cited by 21 publications

References 76 publications

Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility

Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility

The Impact of Multiple Functional Layers in the Structure of Magnetic Nanoparticles and Their Influence on Albumin Interaction

Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

Contact Info

Product

Resources

About

Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy