Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a  Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde

Mainsah, Evans N.; Ntum, Sally-Judith E.; Conde, Mariam Asseng; Chi-Tangyie, George; Raftery, James; Ndifon, Peter T.

doi:10.4236/csta.2019.84004

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Particularly, the strong v(C=N) vibrations in all compounds is a confirmation of the successful condensation reaction (imine bond formation) that lead to the hydrazones formation. This is in agreement with previous reports (Mainsah et al;2019, Ntum et al;2020, Moustafa et al;2022).…”

Section: Discussionsupporting

confidence: 94%

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Muhammad,

Ibrahim,

Ayo

et al. 2024

FJS

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N’-(2-pyridinylmethylene)nicotinohydrazide A, N’-(4-pyridinylmethylene)nicotinohydrazide B, N’-(2- ethoxybenzylidene)nicotinohydrazide C, N’-(4- ethoxybenzyldene)nicotinohydrazide D and N’-(2-hydroxyl-5-methoxybenzylidene)nicotinohydrazide E, was prepared by refluxing the ethanolic solution of nictonic acid hydrazide and ethanolic solutions of 2-pyridinrcarboxaldehyde, 4-pyridinecarboxaldehyde, 2-ethoxybenzaldehyde, 4-ethoxybenzaldehyde and 2-hydroxy-5-methoxybenzaldehyde in 1:1 mole ratio for 4 hours in a separate reactions. The compounds obtained had a melting point between (120-236 oC) and a percentage yield between (52.38-77.70 %). They were crystalline solids. The compounds' solubility were assessed in water, ethanol, methanol, acetone, hexane, diethyl ether, dimethyl sulfoxide (DMSO), ethyl acetate, and chloroform. The substances were discovered to be fully soluble in DMSO and methanol. FT-IR, 1H-NMR and 13C-NMR were used for the characterization of the compounds. The antibacterial and antifungal properties were tested against Methicillin-resistant Staphylococcus Aureus, Vancomycin-resistant Enterococci, S. aureus, S. typhi, P. aeruginosa, A. nigre, A. flavus, and C. albicans. The zones of inhibitions ranged from 22 to 28 mm and the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were found to be 0.063 mg/mL, 0.125 mg/mL and 0.125 mg/mL respectively. These indicated that the compounds might be good potential drug candidates.

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Section: Discussionsupporting

confidence: 94%

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Muhammad,

Ibrahim,

Ayo

et al. 2024

FJS

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“…Pyridine and its derivatives are used as an important ingredient in the manufacture of important commodities such as medicines [3], vitamins [4], food flavors [1], [5], pesticides [6], paints [7], dyes and pharmacophore [8,9], rubber products [10], adhesives [11], waterproof fabrics, and solvents [12]. The pyridine ring is found in many essential compounds, such as niacin and pyridoxal [13] which are build the structure of vitamin B, isoniazid [14], as well as other compound with antiviral, anti-HIV [15], anticancer, antitumor [2], antibacterial [16], antimalarial [17], anti-inflammatory [18], antidiabetic [19], and antioxidant properties [20]. The worldwide annual production of pyridine reached up to 20,000 tonnes per year [1].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics Theoretical Investigation for Synthesis of Pyridine from Pyrylium Salt using Density Functional Theory

Khoiriah

2023

J. Kartika Kimia

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Pyridine is a heterocyclic compound that is widely used as an ingredient in medicines, vitamins, food flavors, pesticides, dyes, adhesives, and others. Currently, pyridine synthesis is carried out with coal tar as a raw material, which is a non-renewable natural resource. In this research, a theoretical study was carried out to evaluate the synthesis process of pyridine using pyrylium salt as an alternative raw material to displace coal tar. This study also aims to simulate the pyridine synthesis and the energy required or released in the process. Density Functional Theory (DFT) method was employed to calculate some thermodynamic properties of the species involved in the reaction such as enthalpy, entropy, and Gibbs free energy in a vacuum and solvated model in order to study the progress of the reaction and mechanism. Based on the calculation results, the lowest value of enthalpy, entropy, and free energy Gibbs is obtained when the reaction takes place in a vacuum. The change of entropy and free Gibbs energy of the reaction was not predominantly affected by the degree of polarity of the solvent. Meanwhile, the enthalpy of reaction simulated in water solvent is higher than in the ethanol solvent. The synthesis reaction of pyridine from pyrylium salt is exothermic and exergonic because it has a negative value of enthalpy change and Gibbs free energy at 298.15 K, which is potential to be done at room temperature without extreme condition control.

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“…Some research was also dedicated to investigation of the influence of Lewis acids on selected properties of Schiff bases, also for molecules containing pyridine moieties [ 44 , 45 , 46 ]. Additionally, ligands based on the Schiff bases with pyridine are also investigated in coordination chemistry [ 47 ].…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure Determination of 4-[(Di-p-tolyl-amino)-benzylidene]-(5-pyridin-4-yl-[1,3,4]thiadiazol-2-yl)-imine along with Selected Properties of Imine in Neutral and Protonated Form with Camforosulphonic Acid: Theoretical and Experimental Studies

et al. 2021

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The crystal structure was determined for the first time for 4-[(di-p-tolyl-amino)benzylidene]-(5-pyridin-4-yl-[1,3,4]thiadiazol-2-yl)-imine (trans-PPL9) by X-ray diffraction. The imine crystallized in the monoclinic P21/n space group with a = 18.9567(7) Å, b = 6.18597(17) Å, c = 22.5897(7) Å, and β = 114.009(4)°. Intermolecular interactions in the PPL9 crystal were only weak C−H∙∙∙N hydrogen bonds investigated using the Hirshfeld surface. The electronic and geometric structure of the imine were investigated by the density functional theory and the time-dependent density-functional theory. The properties of the imine in neutral and protonated form with camforosulphonic acid (CSA) were investigated using cyclic voltammetry, UV–vis and 1H NMR spectroscopy. Theoretical and experimental studies showed that for the 1:1 molar ratio the protonation occured on nitrogen in pyridine in the PPL9 structure, as an effect of Brönsted acid–base interactions. Thermographic camera was used to defined defects in constructed simple devices with ITO/PPL9 (or PPL9:CSA)/Ag/ITO architecture. In conclusion, a thermally stable imine was synthesized in crystalline form and by CSA doping, a modification of absorption spectra together with reduction of overheating process was observed, suggesting its potential application in optoelectronics.

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Synthesis, Characterization and Crystal Structure of Cobalt(II) Complex of a Schiff Base Derived from Isoniazid and Pyridine-4-Carboxaldehyde

Cited by 3 publications

References 17 publications

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Antibacterial and Antifungal Activities of Some Hydrazones Synthesized From Nicotinic Acid Hydrazide

Thermodynamics Theoretical Investigation for Synthesis of Pyridine from Pyrylium Salt using Density Functional Theory

Crystal Structure Determination of 4-[(Di-p-tolyl-amino)-benzylidene]-(5-pyridin-4-yl-[1,3,4]thiadiazol-2-yl)-imine along with Selected Properties of Imine in Neutral and Protonated Form with Camforosulphonic Acid: Theoretical and Experimental Studies

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