Synthesis, Characterization and Copolymerization of N‐(phenylamino)maleimide with MMA

Hiran, B. L.; Paliwal, S. N.; Choudhary, Jyoti; Choudhary, P. R.

doi:10.1155/2007/234768

Cited by 7 publications

(7 citation statements)

References 8 publications

(8 reference statements)

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“…n-* transitions at 288.0 nm and 298.0 nm, these were due to >C=S in amide linkage and -CHO moiety 24 . …”

Section: Figure 4 Uv-visible Spectra Of Hbte-ii Terpolymer Resinmentioning

confidence: 93%

“…Chem Sci Trans., 2014, 3(1), [19][20][21][22][23][24][25][26][27][28] Azarudeen et al 5 synthesized phthalic acid-urea-formaldehyde terpolymer resin and proved to be a selective chelation ion-exchange terpolymer for metals. A batch equilibrium method was employed to study the selectivity and sorption capacity of the resin towards certain divalent metal ions such as Pb 2+ …”

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confidence: 99%

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Synthesis, Characterization and Ion-Exchange Properties of Terpolymer Resin-II Derived from p-Hydroxybenzaldehyde, Thiourea and Ethylene Glycol

Gupta¹,

Hiwase²,

Kalambe³

2013

Chem Sci Trans

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Ion-exchange resin (HBTE-II) was synthesized by polycondensation in the presence of polyphosphoric acid as a catalyst using monomers p-hydroxybenzaldehyde (0.2 M), thiourea (0.1 M) and ethylene glycol (0.4 M) at 120 0 C. The terpolymer resin was characterized by elemental analysis, the number average molecular weight, UV-Visible, IR and 1 H NMR spectrum. Chelating ion-exchange properties of this copolymer were studied for Bi 3+ , Sb 3+ , Zn 2+ and Mg 2+ ions. A batch equilibrium method was employed in the study of the selectivity of metal ion uptake involving the measurements of the distribution of a given metal ion between the polymer sample and a solution containing the metal ion. The study was carried out over a wide pH range and in media of various ionic strengths. The metal ions were estimated spectrophotometrically. The HBTE-II terpolymer resin was found to be selective chelating ion-exchange resin for Sb 3+ , Bi 3+ and Zn 2+.

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“…n-* transitions at 288.0 nm and 298.0 nm, these were due to >C=S in amide linkage and -CHO moiety 24 . …”

Section: Figure 4 Uv-visible Spectra Of Hbte-ii Terpolymer Resinmentioning

confidence: 93%

mentioning

confidence: 99%

Synthesis, Characterization and Ion-Exchange Properties of Terpolymer Resin-II Derived from p-Hydroxybenzaldehyde, Thiourea and Ethylene Glycol

Gupta¹,

Hiwase²,

Kalambe³

2013

Chem Sci Trans

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“…H4-H5 was synthesized by acylation reaction on the amino with anhydride as an acylation reagent (Hiran et al, 2007). Briefly, amino tadalafil (0.2 mmol) and anhydrides (0.24 mmol) were dissolved in DMF (0.5 ml) and refluxed for 3 h at 60 • C. The DMF was removed under vacuum at 75 • C and the yellowish oily product was obtained.…”

Section: Synthesis Of Haptens H4-h5mentioning

confidence: 99%

Improved molecular softness of tadalafil hapten enhancing antibody performance in immunoassay: Evidence from computational chemistry

Yang

Xie

Tan

et al. 2022

Journal of Food Science

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The tadalafil-like compounds have appeared recently as adulterants in drinks and healthcare dietary supplements sourced from medicinal and edible food, which may cause illness and even death. In this work, the rationality of haptens was explored by computational chemistry and molecular simulation theories such as frontier molecular orbital (FMO)-based softness (S), three-dimensional (3D) structure, surface electrostatic potential (ESP), and lipophilic potential (LP). An antiserum from hapten H5 with the highest softness and maintaining the appropriate three-dimensional (3D) structure showed the optimal immunoassay performance, indicating an increasing softness was a critical factor for effective hapten. Based on the antibody induced by hapten H5, an indirect competitive enzyme-linked immunosorbent assay (icELISA) method for detecting multiple tadalafil-like adulterants was established. The icELISA showed a limit of detection (LOD), 50% inhibition concentration (IC 50 ), and a working range of 0.004-0.396, 0.89-4.27, and 0.094-16.71 ng/ml for tadalafil, amino tadalafil, acetamino tadalafil, nortadalafil, and N-desmethyl ent-tadalafil, respectively. The spiked recoveries of tadalafil-like adulterants in samples ranged from 84.9% to 116.2%. The results of the icELISA and HPLC-MS/MS methods had a good correlation for real samples with the R 2 of 0.9955. Specially, this work not only provided a convenient immunoassay method for measuring tadalafil-like adulterants in spirit drinks and dietary supplements in group-screening manner, but also suggested that softness was likely to be a general theory for rational hapten design.

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“…The polymerization process was done in both homogeneous and heterogeneous forms according to the literature [23].…”

Section: Synthesis Of Polymersmentioning

confidence: 99%

Preparation and Characterization of New Carrier Drug Polymers Based Maleimide and Its Drug Release Behaviour

2019

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In this work, two new drug substituted monomers and new homogenous and heterogeneous polymers were synthesized loaded with medicinal properties to extend the controlled drug. The first step includes preparation of compound (F1) via reaction of maleic anhydride with 4-aminobenzoic acid. Then compound (F1) was converted to its corresponding acyl chloride derivative which reacted with amino drugs (sulfadiazine, chlordiazepoxide) afforded (F2 and F3) monomers. Homogeneous polymers (F8 and F9) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. Heterogeneous polymers (F14 and F15) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) separately with acrylic acid under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. All these prepared monomers and polymers were characterized by FT-IR and 1H NMR, 13C NMR spectroscopies. Controlled drug release and swelling % was studied in different pH values at 37 ºC. Intrinsic viscosities were measured at 25 ºC with Ostwald viscometer and applied the characteristic of solubility for these polymers.

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Synthesis, Characterization and Copolymerization of N‐(phenylamino)maleimide with MMA

Cited by 7 publications

References 8 publications

Synthesis, Characterization and Ion-Exchange Properties of Terpolymer Resin-II Derived from p-Hydroxybenzaldehyde, Thiourea and Ethylene Glycol

Synthesis, Characterization and Ion-Exchange Properties of Terpolymer Resin-II Derived from p-Hydroxybenzaldehyde, Thiourea and Ethylene Glycol

Improved molecular softness of tadalafil hapten enhancing antibody performance in immunoassay: Evidence from computational chemistry

Preparation and Characterization of New Carrier Drug Polymers Based Maleimide and Its Drug Release Behaviour

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