Synthesis, characterization, and controlled release of selenium nanoparticles stabilized by chitosan of different molecular weights

Zhang, Chunyue; Zhai, Xiaona; Zhao, Guanghua; Ren, Fazheng; Leng, Xiaojing

doi:10.1016/j.carbpol.2015.07.065

Cited by 156 publications

(114 citation statements)

References 57 publications

(56 reference statements)

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“…Thus, Se obtained were of various morphologies, such as amorphous, sphere, wire, rob and tube. 15,16,19,24,26,36 Herein, aqueous Se(IV) was chemically reduced by Vc to synthesize SeNPs in the presence of CTS. The initial colloid nucleated and then …”

Section: Morphology and Formation Of Cts-senpsmentioning

confidence: 99%

“…15,16 Actually, even an increase in the size of SeNPs can lead to significant reduction in the activities of these nanoparticles such as scavenging multiple radical species in vitro 6 and enhancing Se accumulation and GSH S-transferase activity in vivo. 17 It has also been proved that SeNPs are most effective as a chemopreventive agent at a smaller particle size.…”

mentioning

confidence: 99%

“…Over the past decade, much effort had been devoted to synthesize and stabilize SeNPs with the use of polysaccharides, 15,[18][19][20] monosaccharides, 21 proteins, 3,[22][23][24] amino acids, 25 polyphenols, [26][27][28] melatonin, 29 ATP, 30 complex plant extract 10,31 and even microorganism culture. 8 Among them, polysaccharide is regarded as an appropriate template for fabricating SeNPs when considering energy efficiency and eco-friendliness, according to Zhang et al 15 However, the SeNPs prepared using polysaccharides were found to be unstable, due to enlargement of size and decrease of zeta potential during storage in aqueous environment.…”

mentioning

confidence: 99%

“…8 Among them, polysaccharide is regarded as an appropriate template for fabricating SeNPs when considering energy efficiency and eco-friendliness, according to Zhang et al 15 However, the SeNPs prepared using polysaccharides were found to be unstable, due to enlargement of size and decrease of zeta potential during storage in aqueous environment. 15,19 Moreover, SeNPs preserved using aqueous polysaccharide often encounter and form aggregates. Hence, an improved method of synthesizing SeNPs is needed.…”

mentioning

confidence: 99%

“…Besides, the physical and chemical characteristics of SeNPs-M were investigated for a deeper understanding of the bioactivities of SeNPs-M to evaluate the application of SeNPs in this from. synthesis of seNPs and seNPs-M SeNPs were synthesized by reducing selenite as described by Zhang et al 15 with small modification. In brief, 0.5 g of CTS and 1.6 g of Vc were dissolved in 100 mL of 1% (w/w) acetic acid.…”

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confidence: 99%

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Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Bai¹,

Hong²,

He³

et al. 2017

IJN

150

133

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Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated. Institute of Cancer Research mice were used as model animal to evaluate the bioactivities of SeNPs-M. Trigonal-phase SeNPs of ~35 nm were synthesized, and SeNPs-M physically embedding those SeNPs were successfully prepared. Amazingly, acute toxicity test indicated that SeNPs-M were much safer than selenite in terms of Se dose, with a LD 50 of around 18-fold of that of selenite. In addition, SeNPs-M possessed powerful antioxidant activities, as evidenced by a dramatic increase of both Se retention and the levels of glutathione peroxidase, superoxide dismutase and catalase. The design of SeNPs-M can offer a new way for further development of SeNPs with a higher efficacy and better biosafety. Thus, SeNPs-M may be a potential candidate for further evaluation as an Se supplement with antioxidant properties and be used against Se deficiency in animals and human beings.

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Section: Morphology and Formation Of Cts-senpsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Bai¹,

Hong²,

He³

et al. 2017

IJN

150

133

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Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

236

146

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Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se‐based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug‐loaded SeNP to tumor sites, thus avoiding off‐target effects.

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Nanocarriers for the treatment of glioblastoma multiforme: A succinct review of conventional and repositioned drugs in the last decade

Bayoumi,

Youshia,

Arafa

et al. 2024

Archiv der Pharmazie

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Glioblastoma multiforme is a very combative and threatening type of cancer. The standard course of treatment involves excising the tumor surgically, then administering chemotherapy and radiation therapy. Because of the presence of the blood–brain barrier and the unique characteristics of the tumor microenvironment, chemotherapy is extremely difficult and has a high incidence of relapse. With their capacity to precisely target and transport therapeutic medications to the tumor while overcoming the challenges provided by invasive and infiltrative gliomas, nanocarriers offer a potentially beneficial treatment option for gliomas. Drug repositioning or, in other words, finding novel therapeutic uses for medications that have received approval for previous uses has also recently emerged to provide alternative treatments for many diseases, with glioblastoma being among them. In this article, our goal is to shed light on the pathogenesis of glioma and summarize the proposed treatment approaches in the last decade, highlighting how combining repositioned drugs and nanocarriers technology can reduce drug resistance and improve therapeutic efficacy in primary glioma.

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Synthesis, characterization, and controlled release of selenium nanoparticles stabilized by chitosan of different molecular weights

Cited by 156 publications

References 57 publications

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Nanocarriers for the treatment of glioblastoma multiforme: A succinct review of conventional and repositioned drugs in the last decade

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