Synthesis, characterization and chlorhexidine release from either montmorillonite or palygorskite modified organoclays for antibacterial applications

Lobato-Aguilar, Héctor A.; Uribe-Calderón, Jorge; Herrera‐Kao, Wilberth; Duarte-Aranda, S.; Baas-López, José Martín; Escobar, Beatriz; Cauich-Rodríguez, J.V.; Cervantes‐Uc, José Manuel

doi:10.1016/j.jddst.2018.06.007

Cited by 27 publications

(26 citation statements)

References 21 publications

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“…Total CEC values were inside the expected CEC limits for sepiolite (9.18 mEq/100 g) and palygorskite (16.29 mEq/100 g) [ 68 , 69 ]. Sepiolite and palygorskite CEC are usually <25 mEq/100 g [ 70 ] with higher values usually related to impurities [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ]. The higher CEC showed by G30 with respect to PS9 could be explained by the presence of 6% w / w of smectites and/or sepiolite in G30, as previously described.…”

Section: Resultsmentioning

confidence: 99%

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

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Background: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.

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Section: Resultsmentioning

confidence: 99%

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

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“…The resulting materials were successfully characterized by energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, X-ray diffraction as reported elsewhere, 15 and the amount of CA loaded in nanoclays is shown in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…14 This clay offers interesting characteristics such as microporosity and large specific area and it can be used to yield hybrid materials by interaction with diﬀerent types of organic species through the external surface and, in some cases, the internal surface of this mineral. 15…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial properties and release kinetics of chlorhexidine diacetate from montmorillonite and palygorskite clays

et al. 2019

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Organoclays were prepared by means of cation-exchange reactions using different concentrations of chlorhexidine diacetate and two different types of clays: montmorillonite and palygorskite. The antibacterial activity against Escherichia coli was evaluated by means of disk diffusion tests as well as through bacterial growth inhibition (monitored by optical density measurements) in Luria broth media. Results indicate that modified palygorskites showed a greater antibacterial activity than those exhibited by modified montmorillonite, as latter only displayed antibacterial properties at the highest chlorhexidine diacetate loading. Modeling of chlorhexidine release was also performed and the models best described the drug release phenomena depended on the type of clay; being the Higuchi model and Korsemeyer–Peppas model for montmorillonite, whereas the zero-order model and Korsemeyer–Peppas model for palygorskite.

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“…Encapsulating the drug into the nanoclays’ interlaminar space might be an effective strategy to address the challenge of prolonged dosing regimens and subsequently to enhance therapeutic efficiency of the bioactive compounds by keeping the active agent concentration in the local targeted environment within the therapeutic range, as long as the treatment requires, as recently studied [ 30 , 31 , 32 , 33 , 34 ]. The challenge in designing an ideal long-term drug delivery system is to balance the ease and safety of administration with the adjustment/modeling of the drug release rate at the appropriate concentration to obtain the desired long-term therapeutic effect [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A New Long-Term Composite Drug Delivery System Based on Thermo-Responsive Hydrogel and Nanoclay

et al. 2020

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Several problems and limitations faced in the treatment of many diseases can be overcome by using controlled drug delivery systems (DDS), where the active compound is transported to the target site, minimizing undesirable side effects. In situ-forming hydrogels that can be injected as viscous liquids and jellify under physiological conditions and biocompatible clay nanoparticles have been used in DDS development. In this work, polymer–clay composites based on Pluronics (F127 and F68) and nanoclays were developed, aiming at a biocompatible and injectable system for long-term controlled delivery of methylene blue (MB) as a model drug. MB release from the systems produced was carried out at 37 °C in a pH 7.4 medium. The Pluronic formulation selected (F127/F68 18/2 wt.%) displayed a sol/gel transition at approx. 30 °C, needing a 2.5 N force to be injected at 25 °C. The addition of 2 wt.% of Na116 clay decreased the sol/gel transition to 28 °C and significantly enhanced its viscoelastic modulus. The most suitable DDS for long-term application was the Na116-MB hybrid from which, after 15 days, only 3% of the encapsulated MB was released. The system developed in this work proved to be injectable, with a long-term drug delivery profile up to 45 days.

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Synthesis, characterization and chlorhexidine release from either montmorillonite or palygorskite modified organoclays for antibacterial applications

Cited by 27 publications

References 21 publications

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Antibacterial properties and release kinetics of chlorhexidine diacetate from montmorillonite and palygorskite clays

A New Long-Term Composite Drug Delivery System Based on Thermo-Responsive Hydrogel and Nanoclay

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