Synthesis, characterization and biological studies of mononuclear copper(II) complexes with ciprofloxacin and N, O donor ligands

Acidic Alumina Catalysed One Pot Synthesis and Antimicrobial Activity of 1,3,6-Trisubstitutedpyrimidine-2,4-dione Uracils

“…Compounds related to the title heterocycles have been found to be associated with attractive pharmacotherapeutic profiles such as analgesic, anti-inflammatory, and anti-pyretic biological profiles. [1][2] The title compounds, 1,3,6-trisubstitutedpyrimidine-2,4-diones, have been synthesized by methods such as by the condensation between the monosubstitutedureas and the diketene, by condensing the monosubstitutedureas and ethylacetoacetate in the presence of conc. H 2 SO 4.…”

“…H 2 SO 4. [2][3][4][5]These methods yield 1 or 3-substituted-6-methyl uracils which are subsequently alkylated to give the 1,3-disubstituted-6-methyluracil. A recent method for the synthesis of these compounds involves the condensation of a disubstituted urea with an excess of acetic anhydride in presence of 4-methylpyridine solution but the method gives moderate yields and includes a series of tedious extractions work-up.…”

DNA binding and biological activity of mixed ligand complexes of Cu(II), Ni(II) and Co(II) with quinolones and N donor ligand

“…Based on the increased activity shown by metaldrugs complexes in comparison to their parent compounds 6 , diverse complexes of metal and quinolone ligands have been synthesized and characterized. Their interaction with DNA [7][8][9][10] and serum albumin proteins [11][12][13][14] , their antibacterial activity [15][16][17] and potential antitumor activity [18][19][20] have been evaluated in comparison to free quinolones. Mixed ligand of nickel and copper with quinolones using NN donor ligands have been synthesized and explored for their biological activities [21][22][23] .…”

Synthesis, Characterization and Biological Approach of N’-(3-(Hydroxy Imino) Butan-2-ylidene)-2-Oxo-2H-Chromene-3-Carbohydrazide Complexes

“…Besides, they found in different oils as ''lavender oil, cinnamon bark, oil and cassia oil'' [4]. Moreover, coumarin derivatives have changed uses such as '' optical brightening agents, laser dyes, cosmetic industry agrochemical industries and food additives'' [5][6][7]. Furthermore, Coumarin derivatives have important biological activity as antibacterial, antifungal, anti-oxidant, anti-allergic, antiinflammatory, anti-thrombotic, hepatoprotective, anti-viral, anticarcinogenic activities [8][9][10].…”