Synthesis, characterization and biological studies of S-4-methylbenzyl-β-N-(2-furylmethylene)dithiocarbazate (S4MFuH) its Zn2+, Cu2+, Cd2+ and Ni2+ complexes

Unusual saccharin-N,O (carbonyl) coordination in mixed-ligand copper(II) complexes: Synthesis, X-ray crystallography and biological activity

“…and C 6 H 4 . [18], respectively. Both MT2APH and ET2APH also had similar fragmentation patterns with a base peak at m/z 105 but displayed fragmentation corresponding to C 2 H 2 N 3 S .+ and C 6 H 5 N2 + .…”

“…The tridentate Schiff base derived from salicyldehyde and thiosemicarbazide was found to be inactive against both MCF-7 and MDA-MB-231 cancer cells but the mixed ligand Cu(II) complex containing the Schiff base and imidazole had notably enhanced cytotoxicity [50]. The enhanced bioactivities of metal complexes as compared to free ligands can be due to the chelation effect, whereby metal ions bind with multidonor chelating ligands to create compounds that are more lipophilic and enter the cell more easily as compared to the chelating ligand itself [51] Complexes complexes also create a higher potency to interact effectively with the DNA of the cancer cells leading in turn to an enhanced cytotoxicity [18].…”

“…More recently, the DNA binding and cytotoxic assay studies of Cu(II), Ni(II), Zn (II) and Cd(II) complexes derived from S-substituted dithiocarbazate Schiff bases have been reported, but interestingly, only Cu(II) complexes showed promising biological activities and this was supported by the DNA binding affinity of the Cu(II) complexes which was postulated to be due to the ability of the complexes to block the enzymatic binding to the nitrogen bases of DNA or RNA of the cancer cells [18,19]. Several other copper complexes have been reported to have effective anti-inflammatory, antirheumatic and anticancer activities, which was associated with their superoxide dismutase-like activity [20].…”

Homoleptic tin(IV) compounds containing tridentate ONS dithiocarbazate Schiff bases: Synthesis, X-ray crystallography, DFT and cytotoxicity studies

“…A number of reports [23][24][25][26][27][28][29][30][31] on the complexation of dithiocarbazate Schiff bases have received much attention because of their special abilities, including (i) formation of an interesting series of ligands where the properties can be greatly modified by introducing different types of aldehyde or ketones and (ii) the interaction of donor atoms to the centre metal ions creating different geometries and properties, as well as their potential biological activities [32]. The number and diversity of applications of tin(IV) compounds, and the synthesis and characterisation of tin(IV) compounds containing O-, N-, S-donor Schiff bases have been a subject of interest for researchers in the inorganic field, where sulphur is of paramount importance in the metal-ligand linkage.…”

Synthesis, characterisation and structure determination of 3-[(1Z)-{2-[bis({[(2-methylphenyl)methyl]sulfanyl})methylidene]hydrazin-1-ylidene}methyl]benzene-1,2-diol

“…Since the 1980's, many Schiff bases derived from dithiocarbazates have been synthesised, characterised and investigated especially for their pharmaceutical potential [1]. The variety of coordination modes in dithiocarbazates and the ease of modification by introducing different organic substituents to the dithiocarbazate derivatives [2][3][4][5][6][7] have been of interest as relatively small modifications in the structural backbone often gives rise to major differences in their biological properties. For example, many of these compounds display selective in vitro biological activity against several cancer cell lines [4,5,[7][8][9][10][11].…”