Synthesis, characterization and biological studies on divalent transition metal complexes of schiff bases derive from condensation of pyridine derivatives

Abstract

New Schiff-base ligand derived from the condensation of 1, 2, 3 triamino propane 1, 3 diamino propane 2ol with 2 fomyl pyridine (=FPTN and FPTNOL) and 2-acetyl pyridine (=APTN and APTNOL) and their Copper (ii) and Nickel(ii) transition metal complexes have been synthesized and characterized by IR spectra, electronic spectra, magnetic susceptibility molar index and elemental analysis. All complexes contain a 1:1 ratios of tetra dentate ligand to metal (II) salt. Copper (II) complexes of the type [Cu(L)I] ClO4 and formed to be five coordinated, while (CuL) (ClO4)2 are formed tetragonal or square planner in structure. The IR spectra of Cu(II) and Ni(II) Cheates support the Schiff base formulation of the ligands and provide evidence for the co-ordination of the pyridine groups. A tetragonal crystal field model provides a basis for the interpretation of the visible and near IR, Electronic spectra of Ni(II) complexes with the tetradentate ligand occupying the square planer arrangement. The complex NiLx2nH2o where L= FPTN, FPTNOL, APTN, APTNOL, X= Cl, NO2 or NCSbehaves as 2:1 electrolytes in aqueous solution and give rise to a common species [Ni(L)(H2O)2] +2 . In aqueous the complex ion [Ni(L)(H2O)2] +2 reacts with neutral dentate donors to yield [Ni(L) (donor)2] +2 the 1 H and 13 C n.m.r. spectral data confirmed the suggested structure for the Schiff base ligand and mass spectra results confirmed the proposed structure of the legend. The antimicrobial activities, properties of the ligand and their metal complexes have been studied.