Synthesis, Characterization, and Biological Properties of Novel Bioactive Poly(xanthoneamide‐triazole‐ethersulfone) and Its Multifunctional Nanocomposite with Polyaniline

Hasantabar, Vahid; Lakouraj, Moslem Mansour; Zare‬, Ehsan Nazarzadeh; Mohseni, Mojtaba

doi:10.1002/adv.21609

Cited by 21 publications

(15 citation statements)

References 55 publications

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“…As presented in TGA curve exhibited weight loss amount, which is almost 30% at 550°C. According to the literature, important part of this weight loss, especially in temperatures more than 300°C, is due to the loss of N 2 from azine section, triazole ring decomposition, and maybe single bond tearing. But about ferrocene scaffold, it is noteworthy that it is one of the first organometallic compounds that remain intact up to 500°C .…”

Section: Resultsmentioning

confidence: 99%

“…According to our previous works in the synthesis and investigation of the bioactive polymers that were containing the 1,2,3‐triazole rings and xanthone moiety, and by reviewing the other projects that determined the antibacterial activity of the ferrocene and azine base material, it was decided to investigate the antibacterial activity of the synthesized polymer that have several active sites for bacteria denaturation. Hence, the in vitro antibacterial activity of the synthesized polymer containing 1,2,3‐triazole, ferrocene, xanthone, and azine units against clinical isolates of Gram‐positive and Gram‐negative pathogens such as E coli (ATCC 25922), S aureus (ATCC 25923), K pneumoniae (NCTC 5056), P aeruginosa (1561), and B subtilis 1715 (PY79) bacterial strains was tested and compared with penicillin, ciprofloxacin, and gentamicin as reference antibacterials.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 89%

“…According to our previous works in the synthesis and investigation of the bioactive polymers that were containing the 1,2,3-triazole rings and xanthone moiety, 53,54 and by reviewing the other projects that Three antibiotics were selected for their antibacterial activity through standard bacteria strains according to However, B subtilis and S aureus were sensitive toward gentamicin and penicillin antibiotics according to antimicrobial measurements data given in Table 2. Comparison of the synthesized polymer with the known commercial antibiotics is not logical.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…In continuation of our previous works on the synthesis of functional polymers and their nanocomposites with biological properties and capability in removal of cationic water pollutants, herein, the synthesis, characterization, and some biological aspect of poly(azine ferrocene‐triazole‐xanthone amide) (PAFTXA) with reliable bioapplications were discussed in details. The purposes of the current study were design, preparation, characterization, and investigation of biological properties of novel‐clicked polymer‐bearing biologically valuable moieties of ferrocene, xanthone, triazole ring, and azine bond in the main chain.…”

Section: Introductionmentioning

confidence: 99%

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Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

Lakouraj

Hasantabar

Tashakkorian

et al. 2018

Polymers for Advanced Techs

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Poly(azine ferrocene‐triazole‐xanthone amide) (PAFTXA) was successfully synthesized from azine ferrocene bisacetylene (AFcB) and 2,7‐(N‐2‐azidoacetamide) xanthone (NAzX) by using click chemistry protocol. In this paper, innovative AFcB moiety incorporated in this procedure as a monomer. This monomer was prepared in three steps from ferrocene scaffold, and the synthetic processes were discussed in details. Characterization of the synthesized novel intermediate materials, monomer, and the resulting polymer was performed by nuclear magnetic resonance, Fourier transform infrared, thermal gravimetric analysis, differential scanning calorimetry, and ultraviolet‐visible spectrophotometer. In addition, the in vitro antibacterial activity of the polymer was appraised against Gram‐positive and Gram‐negative bacteria by using minimum inhibitory concentration method. Moreover; antitumoral effects of synthesized polymer were evaluated on Hela, MCF‐7, and Saos cancer cell lines and compared with normal fibroblast cell line by means of 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. Promising antiproliferative effects were detected on both epitheloid and mesenchymal cancer cell lines depending on PAFTXA concentration and time. Survey on its characteristic features revealed the proficiencies of our prepared biomaterial such as its high thermal stability as well as valuable antitumoral and antibacterial capabilities that make it an appreciable candidate for further bioapplications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 89%

Section: Antibacterial Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

Lakouraj

Hasantabar

Tashakkorian

et al. 2018

Polymers for Advanced Techs

Self Cite

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Advances in Antimicrobial Microneedle Patches for Combating Infections

et al. 2020

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Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.

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The synergistic impact of multi walled carbon nanotubes on microstructural, morphological, and optical properties of polyaniline films

Mathew,

Radhakrishnan,

Pragash

et al. 2024

ChemistrySelect

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Nanocomposite of polyaniline (PANI) and multi walled carbon nanotube (MWCNT) was synthesised by ex‐situ solution mixing process in the N‐Methyl‐2‐Pyrrolidinone (NMP) solvent medium by varying the concentration of MWCNT in the PANI matrix. PANI‐MWCNT composite films were prepared by the drop casting method. The morphology, structure and chemical composition of PANI and PANI‐MWCNT nanocomposites were characterised by scanning electron microscopy (SEM), transmission electron microscopy (TEM), x‐ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT‐IR) spectra. The experimental findings suggested a favourable synergy between PANI and MWCNTs. PANI‐MWCNT nanocomposite formed as randomly oriented nanofibrous clusters was confirmed, and the bandgap of the composites was found to be gradually decreased with the increase in concentration of MWCNT in the PANI matrix. The calculation of crystallinity index, crystallite size, average d‐spacing, dislocation density, lattice strain, and inter chain separation of the samples were conducted by XRD analysis. When the MWCNT concentration increased from 0.05 % w/v to 0.5 % w/v, a rise in the degree of crystallinity from 3.39 % to 52.46 %, dislocation density from 0.03315×10−3(nm−2)to 0.07133×10−3 (nm−2) and lattice strain from 8.6821×10−3 to 12.9843×10−3, accompanied by a reduction in both crystallite size and inter‐chain separation were observed .The microcrystalline behaviour and crystalline orientation of the PANI‐MWCNT composites were correlated with the bandgap studies. The composite formation improved the thermal stability of PANI. The co‐relation between the crystallinity parameters and fine tuning of optical bandgap and the control over the defect levels were done in this study. This synergy suggests that these composites are suitable candidates for linear and nonlinear optical (NLO) applications.

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Synthesis, Characterization, and Biological Properties of Novel Bioactive Poly(xanthoneamide‐triazole‐ethersulfone) and Its Multifunctional Nanocomposite with Polyaniline

Cited by 21 publications

References 55 publications

Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

Advances in Antimicrobial Microneedle Patches for Combating Infections

The synergistic impact of multi walled carbon nanotubes on microstructural, morphological, and optical properties of polyaniline films

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