Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol

Chin, Lee Fang; Kong, Siew Ming; Seng, Hoi Ling; Khoo, Kong Soo; Vikneswaran, Rajamurthy; Teoh, Siang Guan; Ahmad, Munirah; Khoo, Soo Beng; Maah, Mohd Jamil; Ng, Chew Hee

doi:10.1016/j.jinorgbio.2010.11.018

Cited by 33 publications

(4 citation statements)

References 71 publications

(78 reference statements)

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“…5). 26,27 Measurements with intermediate H 2 O/DMSO ratios showed consistent results: 11-14 O À1 cm 2 mol À1 (t = 0-24 h) in 50% DMSO and 50-71 O À1 cm 2 mol À1 (t = 0-24 h) in 5% DMSO. The EPR spectra did not show these effects since the hyperfine parameter is primarily defined by the equatorial plane around the vanadium.…”

Section: Molar Conductivity and Electronic Spectrummentioning

confidence: 60%

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Restrepo,

Huamani,

Velásquez Bravo

et al. 2024

New J. Chem.

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Section: Molar Conductivity and Electronic Spectrummentioning

confidence: 60%

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Restrepo,

Huamani,

Velásquez Bravo

et al. 2024

New J. Chem.

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“…The environment about each copper(II) atom in ( 3 ) is a distorted octahedron, with Cu-N1(phen), Cu-N2(phen), Cu-N3(amino-4,4'-bipy), Cu-O1(OH 2 ), Cu-O6(ONO 2 ) and Cu-O5(ONO 2 ) bond distances of 2.028, 2.016, 1.986, 2.224, 1.994 and 2.707 Ǻ (Additional file 1 : Table S2). All the complexes ( 1 )–( 4 ) exhibit two peaks in their FTIR spectra in the range of 846–856 and 720–725 cm −1 , which are attributed to ν(C-N-C) vibrations of the coordinated phen [ 35 ]. The presence of 4,4′-bipy in complexes ( 3 ) and ( 4 ) are indicated by two peaks at 1610 and 1026 cm −1 in their FTIR spectra [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

Lai

Maah

Tan

et al. 2022

Malar J

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Background Malaria remains one of the most virulent and deadliest parasitic disease in the world, particularly in Africa and Southeast Asia. Widespread occurrence of artemisinin-resistant Plasmodium falciparum strains from the Greater Mekong Subregion is alarming. This hinders the national economies, as well as being a major drawback in the effective control and elimination of malaria worldwide. Clearly, an effective anti-malarial drug is urgently needed. Methods The dinuclear and mononuclear copper(II) and zinc(II) complexes were synthesized in ethanolic solution and characterized by various physical measurements (FTIR, CHN elemental analysis, solubility, ESI-MS, UV-Visible, conductivity and magnetic moment, and NMR). X-ray crystal structure of the dicopper(II) complex was determined. The in vitro haemolytic activities of these metal complexes were evaluated spectroscopically on B+ blood while the anti-malarial potency was performed in vitro on blood stage drug-sensitive Plasmodium falciparum 3D7 (Pf3D7) and artemisinin-resistant Plasmodium falciparum IPC5202 (Pf5202) with fluorescence dye. Mode of action of metal complexes were conducted to determine the formation of reactive oxygen species using PNDA and DCFH-DA dyes, JC-1 depolarization of mitochondrial membrane potential, malarial 20S proteasome inhibition with parasite lysate, and morphological studies using Giemsa and Hoechst stains. Results Copper(II) complexes showed anti-malarial potency against both Pf3D7 and Pf5202 in sub-micromolar to micromolar range. The zinc(II) complexes were effective against Pf3D7 with excellent therapeutic index but encountered total resistance against Pf5202. Among the four, the dinuclear copper(II) complex was the most potent against both strains. The zinc(II) complexes caused no haemolysis of RBC while copper(II) complexes induced increased haemolysis with increasing concentration. Further mechanistic studies of both copper(II) complexes on both Pf3D7 and Pf5202 strains showed induction of ROS, 20S malarial proteasome inhibition, loss of mitochondrial membrane potential and morphological features indicative of apoptosis. Conclusion The dinuclear [Cu(phen)-4,4′-bipy-Cu(phen)](NO3)4 is highly potent and can overcome the total drug-resistance of Pf5202 towards chloroquine and artemisinin. The other three copper(II) and zinc(II) complexes were only effective towards the drug-sensitive Pf3D7, with the latter causing no haemolysis of RBC. Their mode of action involves multiple targets. Graphical Abstract

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“…Complex binding with DNA through intercalation usually result in hypochromism and bathochromism due to the strong stacking interaction between an aromatic chromophore and the base pairs of DNA [36]. In the present investigation, the interaction of the bpy-and phen-based complexes (1)(2)(3)(4) in DMF solutions (10%) with ct-DNA have been investigated. Absorption titration experiments of the complexes in buffer were performed by using a fixed concentration of complexes to which increments of DNA stock solution were added.…”

Section: Absorption Titration Study Of Complex-dna Interactionmentioning

confidence: 99%

“…Transition metal complexes such as ruthenium, rhodium, cobalt, nickel, copper, zinc, and lanthanum with nitrogen containing heterocyclic ligands [1,2] have shown binding and cleavage activities with DNA [3,4]. Planar condensed aromatic ligands such as 1,10-phenanthroline, bipyridine, and their derivatives (whose donor properties are similar to purine and pyrimidine bases) in antitumor (DNA-binding) agents have drawn attention to their promising properties [5,6].…”

Section: Introductionmentioning

confidence: 99%

DNA interaction studies of d⁹ and d¹⁰ metal complexes having Schiff base and polypyridyl ligands

Pothiraj¹,

Baskaran²,

Raman³

2012

Journal of Coordination Chemistry

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Four mononuclear complexes of Cu(II) and Zn(II) having a Schiff-base ligand and 1,10-phenanthroline/2,2 0 -bipyridine have been synthesized and characterized. From electronic spectral and magnetic susceptibility data, octahedral geometry has been proposed for the complexes. DNA-binding behaviors of these complexes are studied by absorption titration, electrochemical, and viscosity methods. The results indicate that the complexes bind to calf thymus DNA in an intercalative mode. The gel electrophoresis results reveal that 1 cleaves pBR322 DNA effectively. The ligand and its complexes have been screened for their antimicrobial activities against a few microorganisms. The data exhibit that they are better antimicrobial agents than the ligand.

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Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol

Cited by 33 publications

References 71 publications

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

DNA interaction studies of d⁹ and d¹⁰ metal complexes having Schiff base and polypyridyl ligands

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Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol

Cited by 33 publications

References 71 publications

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

DNA interaction studies of d9 and d10 metal complexes having Schiff base and polypyridyl ligands

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DNA interaction studies of d⁹ and d¹⁰ metal complexes having Schiff base and polypyridyl ligands