Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes — Potent cisplatin analogues and their trans isomers

Serebryanskaya, Tatiyana V.; Yung, Tatiana; Bøgdanov, A.; Shchebet, Andrei; Johnsen, Steven A.; Lyakhov, Alexander S.; Ivashkevich, Ludmila S.; Ibrahimava, Zhanna A.; Garbuzenco, Tatiyana S.; Kolesnikova, Tatiyana S.; Melnova, Natalya I.; Гапоник, П. Н.; Ивашкевич, Олег А.

doi:10.1016/j.jinorgbio.2012.12.001

Cited by 41 publications

(9 citation statements)

References 77 publications

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“…Palladium (II) complexes have recently attracted significant attention due to their biological activities, promising chemotherapeutic and antineoplastic potential and somewhat different mechanisms of action in comparison to platinum-based drugs currently in use [6]. Various palladium (II) complexes such as mononuclear Pd(II) complexes derived from 3-amino-2-methyl-4 (3H)-quinazolinone, some Pd(II) complexes with thiosemicarbazone ligands, Pd (II) complexes from 2,6-diacetylpyridine dioxime and square-planar palladium(II) complexes with O-N-N-O type ligands have been tested in human tumor and cisplatin-resistant tumor cell lines [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Biophysical study on the interaction between two palladium(II) complexes and human serum albumin by Multispectroscopic methods

Saeidifar

Mansouri‐Torshizi

Saboury

2015

Journal of Luminescence

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Section: Introductionmentioning

confidence: 99%

Biophysical study on the interaction between two palladium(II) complexes and human serum albumin by Multispectroscopic methods

Saeidifar

Mansouri‐Torshizi

Saboury

2015

Journal of Luminescence

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“…Palladium has medical application in the timely treatment of tuberculosis, but other options were sought due to deleterious drawbacks. Other medical applications of palladium are their activities as anticancer and antimicrobial agents [51][52][53][54][55][56][57] [55]. ey concluded that moderate activities were obtained from the antibacterial test, while significant activity was obtained from the yeast test.…”

Section: Palladiummentioning

confidence: 99%

Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents

Odularu

Ajibade

Mbese

et al. 2019

Journal of Chemistry

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Platinum-group (PG) complexes have been used as antibacterial and anticancer agents since the discovery of cisplatin. The science world still requires improvement on these complexes because of multidrug and antineoplastic resistances. This review observes discoverers and history of these platinum-group metals (PGMs), as well as their beneficial applications. The focus of this study was biological applications of PGMs in relation to human health. Sandwich and half-sandwich PGM coordination compounds and their metal nanoparticles give improved results for biological activities by enhancing efficient delivery of both antibacterial and anticancer drugs, as well as luminescent bioimaging (biomarkers) for biological identifications.

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“…Both metals in the +2 oxidation state generate square-planar complexes and are soft Lewis acids forming preferentially bonds with N-and S-donors. On the other hand, palladium(II) derivatives are thermodynamically and kinetically less stable than the platinum(II) counterparts, and undergo aquation and ligand exchange much faster [88], thus limiting their medicinal applications [89]. Therefore, an appropriate design of the ligands, including the development of glycoconjugates, would allow the tuning of hydrolysis rates (Fig.…”

Section: Palladiummentioning

confidence: 99%

Metal-based glycoconjugates and their potential in targeted anticancer chemotherapy

Pettenuzzo¹,

Pigot²,

Ronconi³

2016

Metallodrugs

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Glucose is a key source of energy and an essential nutrient for cell growth. Rapidly dividing cancer cells are well-known to require more nutrients and energy than normal ones to sustain their higher proliferation rates, and glucose is no exception. Therefore, the biomolecules involved in the promotion/regulation of the glycolytic flux may be regarded as potential targets for tackling tumor progression. Among all, glucose transporters (GLUTs), devoted to the recognition and cellular internalization of glucose, are largely overexpressed in tumors, thus indicating glycolysis as the major anaerobic glucose metabolism. Accordingly, such increased demand of glucose by fast-proliferating cancer cells makes it very attractive to selectively target tumor sites. In particular, tailored glucose-like substrates can be conjugated to chemotherapeutics (including metal-containing anticancer agents) so as to attain the site-specific delivery of drugs into the affected tissues. Progress in the development of metal-based glycoconjugates are here summarized and discussed.

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Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes — Potent cisplatin analogues and their trans isomers

Cited by 41 publications

References 77 publications

Biophysical study on the interaction between two palladium(II) complexes and human serum albumin by Multispectroscopic methods

Biophysical study on the interaction between two palladium(II) complexes and human serum albumin by Multispectroscopic methods

Developments in Platinum-Group Metals as Dual Antibacterial and Anticancer Agents

Metal-based glycoconjugates and their potential in targeted anticancer chemotherapy

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