Abstract:Thiazolidinedione derivative have Antihyperglycemic activity, they are agonists for the peroxisome proliferator-activated receptor (PPAR), which controls glucose synthesis, transport, and utilization via regulating the transcription of insulin-responsive genes. A number of novel insulin sensitizers are currently being researched. Several of these are derivatives of Thiazolidinedione, but others have different chemical structures. In this work, we created some new Thiazolidinedione derivative based on structure… Show more
“…have synthesized thiazolidinedione derivatives and synthesized compounds were evaluated for their antidiabetic activity. Pyridine containing compound 90 contains a pyridine ring which showed a reduction of blood sugar level at 229.68±4 mg/dL as compared to standard rosiglitazone 229.68±4 mg/dL and it is a good idea to consider using the compound as a lead material for the development of anti‐diabetic medications, as a molecular docking investigation revealed that it exhibits strong antihyperglycemic action [100] . Rathod H.C et al.…”
Section: Discussionmentioning
confidence: 99%
“…Pyridine containing compound 90 contains a pyridine ring which showed a reduction of blood sugar level at 229.68 � 4 mg/dL as compared to standard rosiglitazone 229.68 � 4 mg/dL and it is a good idea to consider using the compound as a lead material for the development of antidiabetic medications, as a molecular docking investigation revealed that it exhibits strong antihyperglycemic action. [100] Rathod H.C et al have designed and synthesized biphenyl carbonitrile-thiazolidinedione conjugates as α-amylase inhibitors. Among which the compound 91 has shown promising αamylase activity with IC 50 : 0.12 μM and when compared to the conventional medication Acarbose, molecular docking data showed a considerable amount of agreement between compounds with significant α-amylase inhibitory activity and their docking scores.…”
Section: Pharmacological Characteristics Of Thiazolidine Analoguesmentioning
The prevalence of diabetes mellitus is on the rise, which demands for the identification of novel antidiabetic drugs. There is a need for safer and more effective alternatives because the therapy methods now available to manage diabetes have limits. Due to their diverse pharmacological characteristics, heterocyclic molecules with nitrogen and Sulfur atoms have become intriguing candidates in medicinal chemistry. These substances have a wide variety of structures that can be customized to target different pathways associated with diabetes and can affect important biological targets involved in glucose homeostasis. This review provides a thorough summary of the most recent studies on heterocyclic analogues of nitrogen and Sulfur as prospective antidiabetic agents. This review examines the variety of their structural forms, their methods of action, and assesses the results of preclinical and clinical investigations on their effectiveness and safety. Additionally, further optimization and development of innovative antidiabetic medications are highlighted, as well as the difficulties and prospects for the future in utilizing the therapeutic potential of these analogues. This study seeks to stimulate additional investigation and cooperation between researchers and medicinal chemists, promoting improvements in the creation of efficient and secure antidiabetic medicines to fulfil the needs in the management of diabetes.
“…have synthesized thiazolidinedione derivatives and synthesized compounds were evaluated for their antidiabetic activity. Pyridine containing compound 90 contains a pyridine ring which showed a reduction of blood sugar level at 229.68±4 mg/dL as compared to standard rosiglitazone 229.68±4 mg/dL and it is a good idea to consider using the compound as a lead material for the development of anti‐diabetic medications, as a molecular docking investigation revealed that it exhibits strong antihyperglycemic action [100] . Rathod H.C et al.…”
Section: Discussionmentioning
confidence: 99%
“…Pyridine containing compound 90 contains a pyridine ring which showed a reduction of blood sugar level at 229.68 � 4 mg/dL as compared to standard rosiglitazone 229.68 � 4 mg/dL and it is a good idea to consider using the compound as a lead material for the development of antidiabetic medications, as a molecular docking investigation revealed that it exhibits strong antihyperglycemic action. [100] Rathod H.C et al have designed and synthesized biphenyl carbonitrile-thiazolidinedione conjugates as α-amylase inhibitors. Among which the compound 91 has shown promising αamylase activity with IC 50 : 0.12 μM and when compared to the conventional medication Acarbose, molecular docking data showed a considerable amount of agreement between compounds with significant α-amylase inhibitory activity and their docking scores.…”
Section: Pharmacological Characteristics Of Thiazolidine Analoguesmentioning
The prevalence of diabetes mellitus is on the rise, which demands for the identification of novel antidiabetic drugs. There is a need for safer and more effective alternatives because the therapy methods now available to manage diabetes have limits. Due to their diverse pharmacological characteristics, heterocyclic molecules with nitrogen and Sulfur atoms have become intriguing candidates in medicinal chemistry. These substances have a wide variety of structures that can be customized to target different pathways associated with diabetes and can affect important biological targets involved in glucose homeostasis. This review provides a thorough summary of the most recent studies on heterocyclic analogues of nitrogen and Sulfur as prospective antidiabetic agents. This review examines the variety of their structural forms, their methods of action, and assesses the results of preclinical and clinical investigations on their effectiveness and safety. Additionally, further optimization and development of innovative antidiabetic medications are highlighted, as well as the difficulties and prospects for the future in utilizing the therapeutic potential of these analogues. This study seeks to stimulate additional investigation and cooperation between researchers and medicinal chemists, promoting improvements in the creation of efficient and secure antidiabetic medicines to fulfil the needs in the management of diabetes.
Cancer is one of the life-threatening diseases accountable for millions of demises globally. The inadequate effectiveness of the existing chemotherapy and its harmful effects has resulted in the necessity of developing innovative anticancer agents. Thiazolidin-4-one scaffold is among the most important chemical skeletons that illustrate anticancer activity. Thiazolidin-4-one derivatives have been the subject of extensive research and current scientific literature reveals that these compounds have shown significant anticancer activities. This manuscript is an earnest attempt to review novel thiazolidin-4-one derivatives demonstrating considerable potential as anticancer agents along with a brief discussion of medicinal chemistry-related aspects of these compounds and structural activity relationship studies in order to develop possible multi-target enzyme inhibitors. Most recently, various synthetic strategies have been developed by researchers to get various thiazolidin-4-one derivatives. In this review, the authors highlight the various synthetic, green, and nanomaterial-based synthesis routes of thiazolidin-4-ones as well as their role in anticancer activity by inhibition of various enzymes and cell lines. The detailed description of the existing modern standards in the field presented in this article may be interesting and beneficial to the scientists for further exploration of these heterocyclic compounds as possible anticancer agents.
Contemporary pharmaceutical chemistry faces several challenges in different directions, including the need for both the potency and specificity of any therapeutic agent. The increasingly demanding low toxicity requirements observed in all patients treated and the need for novelty in intellectual property, given the extensive use of benzenoid and heteroaromatic ring systems in many patents. Such challenges are increasingly met by moving to new and / or unusual ring systems (scaffolds) that lie outside the realm of (hetero) aromatic systems. This critical review examines the biological activities of Thiazolidine derivatives like anti-microbial, anti-cancer, anti-diabetics, antiobesity, anti-oxidant by giving mechanistic insights of the given atypical scaffolds from mainly drawn from the literature of the last five years, which have found applications in modern bioorganic chemistry and Medicinal Chemistry.
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