Synthesis, characterization, and biological evaluation of Schiff base–platinum(II) complexes

Shiju, C.; Dasan, Arish; Bhuvanesh, Nattamai; Kumaresan, S.

doi:10.1016/j.saa.2015.02.030

Cited by 51 publications

(23 citation statements)

References 31 publications

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“…Also, the lipophilic nature of the central atom increased by chelation which serving its penetration to the lipid layer of the cell membrane . The main aim of this work is that these complexes may be utilized as a drug agent in diseases caused by septicemia, E. coli e.g., hospital‐acquired and urinary tract infections …”

Section: Resultsmentioning

confidence: 99%

Structural, spectroscopic, molecular docking, thermal and DFT studies on metal complexes of bidentate orthoquinone ligand

Zayed

El-Samahy

2019

Applied Organom Chemis

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4‐Triphenylmethyl‐1,2‐benzoquinone (TPMBQ) reacted with some metal ions and the structure of the new compounds had been identified. The metal to ligand ratio was 1:2 which was revealed by elemental analysis. The complexes were found to have octahedral geometry and their thermal stability was studied using thermogravimetric analysis technique. The molar conductance measurements revealed the electrolytic nature of the synthesized chelates. The IR spectra concluded the bidentate nature of the TPMBQ ligand while the 1H NMR revealed the presence of water molecules. The XRD spectra of Mn (II) and Fe (III) complexes concluded their crystalline structure while Co (II) and Cu (II) chelates refer to amorphous structures. The geometries of the TPMBQ ligand were optimized using Gaussian 09 W; density functional theory B3LYP method. (DFT)/basis set 6–311++G (d, p). HOMO and LUMO energy values for chelates, chemical hardness and electro‐negativity had been calculated. The ligand and its metal complexes had been examined against different kinds of bacteria such as Proteus vulgaris, Escherichia coli, Staphylococcus aurous and Bacillus subtitles to examine their antimicrobial activity. Molecular docking using Auto Dock tools were utilized.

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Section: Resultsmentioning

confidence: 99%

Structural, spectroscopic, molecular docking, thermal and DFT studies on metal complexes of bidentate orthoquinone ligand

Zayed

El-Samahy

2019

Applied Organom Chemis

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“…Recent reports have shown that platinum Schiff base complexes can also be used to inhibit the growth of human breast, colon and cervical cancer cells [49,50]. These results led us to examine representative examples of new complexes 2a-k, using cisplatin and DMSO (control) as standards, for their cytotoxic properties against three glioma cell lines using the MTT method.…”

Section: Cytotoxicitiesmentioning

confidence: 99%

Synthesis, characterization, and anticancer activities of lipophilic pyridinecarboxaldimine platinum(II) complexes

et al. 2016

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“…The compounds with two or more nitrogen atoms are capable chelating agents, which can easily bind to the metal ions function as a cofactor in enzymatic reactions. In some cases, it is thought that the efficacy is dependent on the selectivity arose from the chelation of drug molecules with trace metals …”

Section: Introductionmentioning

confidence: 99%

“…In some cases, it is thought that the efficacy is dependent on the selectivity arose from the chelation of drug molecules with trace metals. [3][4][5] Thiosemicarbazones are multidentate ligands having three nitrogen atoms. Since the drug potentials of platinum(II), palladium(II), [6,7] and copper(II) [8,9] complexes of some thiosemicarbazones, these metal ions have been commonly used to obtain the complexes of various thiosemicarbazone ligands.…”

Section: Introductionmentioning

confidence: 99%

Iron(III) and nickel(II) complexes of tetradentate thiosemicarbazones: Synthesis, structure, cytotoxicity, and lipophilicity

Süleymanoğlu

Kaya

Erdem‐Kuruca

et al. 2019

J Biochem & Molecular Tox

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Eighteen of the iron(III) and nickel(II) complexes with tetradentate thiosemicarbazidato ligands were synthesized and described, by analytical and spectroscopic methods. Two complexes as an example to the iron and nickel centered ones were crystallographically analyzed to confirm the molecular structures. Cytotoxic effects of the complexes on K562 chronic myeloid leukemia cells were determined by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. For comparison, human umbilical vein endothelial cells (HUVECs) was used as a noncancerous cell line. While four of the iron(III) complexes exhibited the antileukemic effect with 50% inhibition of cell growth (IC50) values in the 3.4 to 6.9 μg/mL range on K562 cell line, the nickel(II) complexes showed no significant effect on both cell lines. The complexes Fe4, Fe5, and Fe6, bearing 4‐methoxy substituent exhibited relatively high antiproliferative activity on both cell lines. Complex Fe3 with 3‐methoxy and S‐allyl groups exhibited a selectivity between K562 and HUVEC cells by IC50 values of 6.9 and >10 μg/mL, respectively. Lipophilicity, a key parameter for bioavailability and oral administration, was found in the range of −0.3 and +1.3 that desired for drug active ingredients. The results were discussed in the context of a structure‐activity relationship.

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Synthesis, characterization, and biological evaluation of Schiff base–platinum(II) complexes

Cited by 51 publications

References 31 publications

Structural, spectroscopic, molecular docking, thermal and DFT studies on metal complexes of bidentate orthoquinone ligand

Structural, spectroscopic, molecular docking, thermal and DFT studies on metal complexes of bidentate orthoquinone ligand

Synthesis, characterization, and anticancer activities of lipophilic pyridinecarboxaldimine platinum(II) complexes

Iron(III) and nickel(II) complexes of tetradentate thiosemicarbazones: Synthesis, structure, cytotoxicity, and lipophilicity

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