Synthesis, characterization and biological evaluation of a novel Cu(II) complex with the mixed ligands 2,6-pyridinedicarboxylic acid and 2-aminopyridine

Preparation of Two Maleic Acid Sulfonamide Salts and Their Copper(II) Complexes and Antiglaucoma Activity Studies

“…In 1 H NMR spectrum of 9 ( Figure S6a, Table 3 Figure S6b) although the hydrate water molecule (H 19 ) was observed in the thermal studies. For both compounds (6 and 9) the acidic hydrogen (H 1 ) were not observed due to the salt formation, although it was distinguishable in 3 1 H NMR spectrum ( Figures S1, S4, S6).…”

“…[10][11][12] One of the methods used in glaucoma treatment is to reduce the production of aqueous humor 10,13 by using carbonic anhydrase inhibitors. 4,5,11,13,14 2-Aminopyridines and benzimidazoles serve as useful chelating ligands in a variety of inorganic and organometallic applications, [15][16][17] and also act as monodentate ligands which coordinate the metal ions through the nitrogen of the ring [16][17][18][19][20][21] in most cases. In addition, there are several works on 2-aminopyridine complexes in which the amino group also participates in coordination.…”

“…22,23 The chemistry of copper(II) carboxylate complexes with N-donor ligands especially with AP (2-animopyridine, 5) and BI (1H-benzimidazole, 8) has been extensively studied over the past few decades. 16,[18][19][20][21] Two types of ligands, generally acids (e.g., carboxylic acids) and bases, e.g., AP or BI, are brought together before coordination to the metal ion in order to prepare the mixed ligand complex compounds. 18,[24][25][26] The metal complexes with mixed ligands have shown better biological activities than the simple ones.…”

“…18,[24][25][26] The metal complexes with mixed ligands have shown better biological activities than the simple ones. 18,19,27,28 In this study, two novel proton transfer compounds (HAP) + (SAMAL) - (6) …”

Heat capacities and thermodynamic properties of a 3D Cu(II) supramolecular complex

“…Moreover, pdca has a biological function in the field of biological chemistry, such as body metabolism, enzyme inhibitor, food sanitizer, and so on [12][13][14]. Thus, complexes assembled with pdca may have potential in biological chemistry.…”