Synthesis, Characterization, and Biological Evaluation of Novel Cyclohexenone Derivatives Incorporating Azo, Triazene, and Tetraazene Moieties

In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents

“…AH1 and AH5 showed the same antibacterial effect against S. aureus (31.5 µg MIC) and E. coli (62.5 µg MIC). The antibacterial effect of the derivatives used in this study was found to be higher than that of Abdel‐Galil et al [ 38 ]…”

“…AH1 and AH5 showed the same antibacterial effect against S. aureus (31.5 µg MIC) and E. coli (62.5 µg MIC). The antibacterial effect of the derivatives used in this study was found to be higher than that of Abdel-Galil et al [38] Abdel-Galil et al [38] reported that compounds AG10, AG12, and were evaluated in vitro in parallel cell-based assays for cytotoxicity and antiviral activity. In one of the previous studies, 46 triazene derivatives (MT1-46) were evaluated in vitro assays for antiviral activity against MVA (Poxviridae) by Tonelli et al [39] None of the compounds exhibited antiviral activity.…”

“…Abdel‐Galil et al [ 38 ] reported that compound AG10 (4‐((1′,6′‐dihydro‐[1,1′:3′,1″‐terphenyl]‐5′(2′ H )‐ylidene)triaz‐1‐en‐1‐yl)‐1 H ‐pyrazole‐3,5‐diamine) had a potent antibacterial effect against S. aureus (62.5 µg MIC) and E. coli (125 µg MIC) in their study with synthesized novel triazene derivatives. In this study, AH2, AH4, AH6‐10, and AH12 (31.5 µg MIC) showed great antibacterial effects against E. coli .…”

“…Abdel‐Galil et al [ 38 ] reported that compounds AG10, AG12, and AG14 showed the best antifungal activity against C. albicans in their study with triazene compounds. In this study, however, AH1 showed the best antifungal activity against C. albicans (ATTC 64548).…”

Access to Functionalized Cyclohex-2-enones from a Multicomponent Cascade Reaction of Readily Available Alkynes, Ketones, and Ethyl Acetoacetate

“…Cascade or tandem processes are one-pot multistep reactions that provide concise approaches to complex structures, and hence, they are powerful for synthetic transformations. − Cascade reactions are environmentally benign and economically efficient because they minimize waste, energy, labor, and time because the intermediates are not isolated and purified. − Recently, cyclohex-2-enone derivatives have attracted a considerable amount of attention − due to their potential applications in drug design and the medicinal industry. The biological activities of many compounds bearing a cyclohex-2-enone moiety have been well established, such as anti-inflammatory, antibacterial, − anticancer, and antimalarial activities.…”