Synthesis, characterization and biological applications of curcumin-lysine based schiff base and its metal complexes

3D Series Metal Complexes Containing Schiff Base Ligand with 2,2'-Bipyridine: Synthesis, Characterization and Assessment of Antifungal Activity

“…Metal complexes of thiosemicarbazones have been explored for nearly 50 years because of their versatile biological activity and prospective use as drugs [1]. Owing to the interest they generate through a variety of biological properties, thiosemicarbazones metal complexes have been employed in medicinal applications ranging from anticancer [2], antitumor [3], antifungal [4,5], antibacterial [6], antmalarial [7,8], antitilarial, [9], antiviral [10,11], antineoplastic [12,13], antileprotic [14], trypanocidal [15,16] and anti-HIV activities [17]. It has been proved that thiosemicarbazones block DNA synthesis in mammalian cells by inhibiting the enzyme, ribonucleoside diphosphate reductase, presumably either via chelation with iron(III) required by the enzyme or because a preferred metal chelate of the inhibitor interacts with the target enzyme [18,19].…”