Synthesis, characterization and biological applications of new copper(II) complexes of aryl hydrazones

Abstract

On treatment of copper(II) acetate with aryl hydrazone ligands, four new solid derivatives of copper(II) were produced in appreciable yields. Various characterization techniques including infrared, UV–visible, NMR, electron paramagnetic resonance and mass spectroscopies, elemental analysis, scanning electron microscopy, powder X‐ray diffraction and thermogravimetric analysis revealed a tetra‐coordination in all the mononuclear crystalline complexes with high thermal stability. Further, significant interaction of these novel complexes with calf thymus DNA via intercalative mode of binding was revealed by electronic absorption spectroscopy. The chemical nuclease activity of the complexes on pBR322 DNA was investigated in the presence and absence of oxidizing agent (H2O2). A potent nuclease activity was observed only in the presence of H2O2. Further, antibacterial and antifungal studies of the new ligands and complexes revealed that the latter possessed comparatively better activity.

Pyrrole‐Fused Benzoxazinones/Quinoxalinones: Molecular Dynamic Simulation, Antiproliferative and Antibacterial Activities

“…A conventional liquid turbidity method was followed to assess their antibacterial activity [23] . A literature‐reported procedure was adopted for preparing the samples [23a] . Five‐fold serial dilutions of the compounds were followed to determine the half‐maximum inhibitory concentration (IC 50 ).…”

Biological Evaluation of Synthesized N‐Cinnamoyl Phenothiazine Derivatives

“…The apparent binding constant was evaluated fluorimetrically by performing a competitive binding assay with ethidium bromide (EB) ( spectra given in SI, Figure S2 ). A competitive binding assay was carried out in the presence of varying concentrations of both PTZ derivatives and EB to investigate their binding properties with DNA.…”

“…These observations insisted us to test the antibacterial activity of N ‐cinnamoyl PTZs (2‐8) , a kind PTZ coupled chalcones. All the synthesized N ‐cinnamoyl PTZs were tested for in‐vitro antibacterial activity against Gram‐positive ( Staphylococcus aureus ) and Gram‐negative ( Escherichia coli , Pseudomonas aeruginosa, Klebsiella pneumoniae ) bacterial strains by conventional liquid turbidity method ,,. The samples were prepared according to the procedure from our previous study .…”

Synthesis, characterization and cytotoxicity of new 2‐isonicotinoyl‐N‐phenylhydrazine‐1‐carbothioamide and its metal complexes

“…Isonicotinic hydrazide (isoniazid, INH) is one of the most important hydrazides due to its wide biological activity as antitubercular, antimicrobial, anticonvulsant, analgesic, anti‐inflammatory, anti‐platelet and anti‐tumor activities . Isoniazid (INH) has very high in vivo inhibitory activity towards M. tuberculosis H37Rv.…”

“…The copper complexes of INH derivatives have been synthesized and the activities of these complexes have been evaluated as antitumor agents. The antitumor activity of the complexes was attributed to the inhibition of ribonucleotide reductase enzyme . Moreover, iproniazid, N′‐isopropylisonicotinohydrazide, is used as antituberculosis and antidepressant drug .…”