Synthesis, characterization and biological activity of some platinum(II) complexes with Schiff bases derived from salicylaldehyde, 2-furaldehyde and phenylenediamine

Gaballa, Akmal S.; Asker, Mohsen S.; Barakat, Atiat S.; Teleb, Said M.

doi:10.1016/j.saa.2006.06.031

Cited by 108 publications

(24 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Knoevenagel condensation between aldehyde and β-diketone act as dicarbonyls and fruitful source of macrocyclic polyaza ligand systems. Among the various β-diketones, curcumin is a versatile compound as their traditional consequence in medicinal field [10][11][12][13][14][15][16][17]. A search through literature reveals that more have been posted on the studies of Schiff bases [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antimicrobial and Anticancer Activities of 14-Membered Macrocyclic Schiff Base Metal Complexes

Palanimurugan¹,

Kulandaisamy²

2018

Asian J. Chem.

View full text Add to dashboard Cite

New cationic 14-membered macrocyclic Schiff base metal complexes have been synthesized by condensation of benzalidene-curcuminyl-4-iminoantipyrine and 2,6-diaminopyridine. Structural characterization of the compounds was done using elemental analysis, molar conductivity, magnetic susceptibility, Mass, SEM, XRD, 1 H NMR, UV-visible, IR and EPR spectra. X-ray diffraction patterns suggested that the size of Schiff base is reduced due to chelation by the metal ion. Different morphologies of synthesized compounds were identified by SEM images. Magnetic moment values, UV-visible and IR spectral studies confirms the square planar geometry of chelates. However [VOL]Cl2 exists in octahedral geometry. Electron spin resonance spectra parameters of [CuL]Cl2 and [VOL]Cl2 complexes were well coinciding with proposed geometries. The in vitro biocidal activities of the compounds were done against some bacterial and fungal strains by disc diffusion method. Anticancer activity of Schiff base and copper complex were carried out by MTT method which reveals that the inhibition against the growth of breast cancer cell line culture for chelate is higher than Schiff base.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antimicrobial and Anticancer Activities of 14-Membered Macrocyclic Schiff Base Metal Complexes

Palanimurugan¹,

Kulandaisamy²

2018

Asian J. Chem.

View full text Add to dashboard Cite

show abstract

“…The Schiff base associated with the 2-furfural exhibit anti-microbial and anti-proliferative properties were already reported (Gaballa et al, 2007;Rajendran et al, 2010;Hranjec et al, 2010). 1,3,4-thiadiazole pharmacophore displayed a wide range of pharmacological activities such as anti-inflammatory, CNS depressant activity and mucomembranous protector (Varandas et al, 2005;Jatav et al, 2008;.…”

Section: Introductionmentioning

confidence: 86%

Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and anti-tubercular activity

Mathew¹,

Mathew²,

George³

et al. 2013

Bangladesh J Pharmacol

View full text Add to dashboard Cite

A series of 5-phenylsubstiuted 1, 3, 4 thiadiazoles clubbed with furan moiety (Fa-Fe) by means of azomethine linkage have been synthesized. All the newly synthesized compounds were characterized by IR, 1 HNMR and Mass analyses. All the synthesized molecules have been predicted as anti-tubercular in nature by PASS in silico approach. In vitro anti-tubercular screening was performed by alamar blue assay method on Mycobacterium tuberculosis H37Rv strain. Among the synthesized derivatives Fb and Fe were active at 3.125 µg/mL against Mycobacterium tuberculosis H37Rv strain. The mechanism of action of the active compounds was carried out by docking of receptor enoyl-ACP reductase. It has been concluded that both Fb and Fe posses a significant interaction of hydrogen bonding and electrostatic attraction with Tyr 158 and Met103 in the active site of enzyme.

show abstract

“…In the present complexes, the 'G' value (4.33) is > 4 indicating that there is no interaction in the complexes. In addition the absence of a half field signal at 1600 G corresponding to DM = ±2 transitions indicates the absence of any Cu-Cu interaction in the complexes (Gaballa et al, 2007;Raman et al, 2004;Lever et al, 1984). (Kivelson and Neiman, 1961) have shown that for an ionic environment g || is 2.3 or larger, but for a covalent environment g || is less than 2.3.…”

Section: Esr Spectramentioning

confidence: 99%

Syntheses, spectral characterization, thermal properties and DNA cleavage studies of a series of Co(II), Ni(II) and Cu(II) polypyridine complexes with some new imidazole derivatives of 1,10-phenanthroline

Ahmed

Khaled

2019

Arabian Journal of Chemistry

View full text Add to dashboard Cite

Please cite this article as: S.K. Ahmed, S. Khaled, Syntheses, spectral characterization, thermal properties and DNA cleavage studies of a series of Co(II), Ni(II) and Cu(II) polypyridine complexes with some new imidazole derivatives of 1,10-phenanthroline, Arabian Journal of Chemistry (2015), doi: http://dx. AbstractIn the present study three new imidazole derivatives of phen, 2-(4-hydroxy-3,5-diiodophenyl) imidazo[4,5-f][1,10]phenathroline L 1 , 2-(2-hydroxy-3,5-diiodophenyl)imidazo[4,5-f][1,10]phenanthroline L 2 , 2-(4-hydroxy-5-iodo-3-methoxyphenyl)imidazo[4,5-f][1,10]phenanthroline L 3 and their nine new polypyridine complexes[M(N-N) 2 (L 1-3 )](OAc) 2 .(nH 2 O) where M is Ni(II), Co(II) and Cu(II) and where (N-N) 2 is 2,2'-bipyridine (bpy) 2 or 1,10-phenanthroline (phen) 2 have been synthesized from the reaction of the metal precursor complexes [M(phen) 2 (OAc) 2 ].(nH 2 O) and [M(bpy) 2 (OAc) 2 ].(nH 2 O) with the respective ligands in ethanol and water. The structures of the compounds were determined with the aid of elemental analysis and FT-IR, UV-Vis., 1 H NMR, ESR spectroscopic methods, magnetic measurements and conductance measurements, further analyzed by powder XRD and thermal studies. Elemental analysis data suggested that the complexes have a 1:2:1 molar ratio among the metal and phen or bpy and L 1 / L 2 or L 3 ligands. The spectral data show that all the complexes were six coordinated and possess octahedral geometry around the metal ions. The X-band ESR spectrum of the Cu(II) in DMSO solution at room temperature were recorded and observed anisotropic g values indicate the presence of metal ion in an octahedral environment. The powder XRD patterns of complexes recorded in the range (2θ = 0-80°) and average crystallite size (d XRD ) was calculated using Scherrer's formula. Thermal decomposition profiles of complexes show high decompound temperatures indicating a good thermal stability. Binding of the complexes with calf thymus DNA (CT DNA) has been investigated by gel electrophoresis. The experimental results indicate that the complexes bind to DNA by intercalation mode and found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.

show abstract

Synthesis, characterization and biological activity of some platinum(II) complexes with Schiff bases derived from salicylaldehyde, 2-furaldehyde and phenylenediamine

Cited by 108 publications

References 35 publications

Synthesis, Characterization, Antimicrobial and Anticancer Activities of 14-Membered Macrocyclic Schiff Base Metal Complexes

Synthesis, Characterization, Antimicrobial and Anticancer Activities of 14-Membered Macrocyclic Schiff Base Metal Complexes

Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and anti-tubercular activity

Syntheses, spectral characterization, thermal properties and DNA cleavage studies of a series of Co(II), Ni(II) and Cu(II) polypyridine complexes with some new imidazole derivatives of 1,10-phenanthroline

Contact Info

Product

Resources

About