Synthesis, Characterization and Biological Activity of Polymer Nickel (Ii) Complex

Abstract

I S S N 2 3 2 1 -8 0 7 x V o l u m e 1 2 N u m b e r 4 J o u r n a l o f A d v a n c e s i n C h e m i s t r y 4387 | P a g e c o u n c i l f o r I n n o v a t i v e R e s e a r c h A p r i l 2 0 1 6 w w w . c i r w o r l d . c o m (DTA and TGA). Conductivity measurement reveals the nonelectrolytic nature of the complex. This confirms that, the anion is coordinated to the metal ion. The IR reveal the metal ion is coordinated via the nitrogen atom of 4-VP. Nickel complex and polymer nickel complex have been tested invitro against number of tumor and number of microorganisms in order to assess their anti tumor and antimicrobial properties. The antimicrobial activity was observed by compounds VP-Ni and MMA-VP-Ni under the screening conditions. The activity against HCT-116 cells was detected for compound VP-Ni (with IC50 value 9.8±0.6 µg/ml), compared with reference standard (24.6±0.3 µg/ml) followed by MMA-VP-Ni (48.3±1.5). In conclusion, this study highlighted the synthesis of polymer nickel complex, and proved the promising biological activity of the synthesized compounds. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF POLYMER NICKEL (II) COMPLEX

A New 1D Ni (II) Coordination Polymer of s-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine

“…Moreover, a great number of nickel complexes having interesting biological activity have been reported for their antifungal [47], anti-inflammatory [48], and antioxidant [49,50] activities. Some Ni (II) complexes bearing N,O-chelating ligands are active towards polymerization, and the resulting coordination polymers were found to have interesting applications in catalysis [51] and biology [52]. In addition, they showed prospective applications as luminescent [53], conductive [54], and for the recovery of trace metal ions [55].…”