Synthesis, characterization and biological activity of diphenyltin(IV) complexes of N‐(3,5‐dibromosalicylidene)‐α‐amino acid and their diphenyltin dichloride adducts

Synthesis, characterization, and in vitro antimicrobial activities of organotin(IV) complexes of Schiff bases with ONO‐type donor atoms

“…The 3 J ( 117/119 Sn-1 H) coupling (42.0-55.6 Hz) due to NMR-active Sn isotopes is visible, and this is a strong indication to the ligation of azomethine nitrogen to Sn atom. The extent of coupling is comparable with the literature values [3,5,19]. In the 1 H NMR spectra of the ligands, the signals at 10.05-10.99 ppm are assigned to the phenolic proton on the aniline moiety ((OH) a , Fig.…”

“…The 1 H NMR spectra of all the ligands display a single signal for the azomethine proton (H-7) at 9.00-9.05 ppm, in a good agreement with the reported data for similar structures [15,19,20,33]. The H-7 NMR signal of tin(IV) complexes downshift to the range 8.61-8.74 ppm, reflecting the more electropositive nature of the tin atom relative to hydrogen.…”

“…Recent studies have focused on their biological [14], particularly antitumor [15][16][17][18], antibacterial [18][19][20][21], antifungal [21,22], and antitubercular, properties [23,24]. Many in vitro studies have been performed to explain the mechanism responsible for the biological activity of these agents.…”

Antiproliferative and anti-tumor activity of organotin compounds

“…The cytotoxic activity of diphenyltin(IV) complexes of N-(3,5-dibromosalicylidene)-␣-amino acid (Scheme 6B) with formulae Ph 2 Sn(L 1 ) (75), Ph 2 Sn(L 3 ) (76), and Ph 2 Sn(L 3 )·Ph 2 SnCl 2 (77) against HeLa, CoLo205 and MCF-7 [38] shows that these compounds possess higher activity than those of the clinically widely used cisplatin. The data reveal that the binuclear adduct 77 is the more active against the three cell lines than the mononuclear complexes 75 and 76 (Table 2).…”

Synthesis and Characterization of Silatranes Derived From Diethoxydichlorosilane

“…Depending on the respective coordination number and electronic properties of the functional ligands, many of these complexes display novel structural features or reactivity blueprints which give rise to various discoveries during the past decades [9]. Hypervalent silicon complexes [10][11][12][13] with Schiff bases have been broadly studied due to their bacteriostatic [14], antimicrobial [15], fungicidal [16,17], biocidal [18], bactericidal [19,20] properties. Here, we report the synthesis and characterization of higher coordinated silicon complexes derived from diethoxydichlorosilane and Schiff bases.…”