Synthesis, Characterization and Biological Activity of the Manganese Complexes with alfa-ketoglutaric Acid and 1-0(o-tolyl) Biguanide

Abstract

This paper presents the synthesis and characterization of three complexes of Mn (II,III), with the a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) as ligands. The complexes corresponding formulas are: [Mn(TB)2(H2A)]Cl2 . 0.5C2H5OH (C1), [Mn2(TB)(A)(H2A)2(H2O)2(NO3)2](NO3)2. C2H5OH (C2) and [Mn2(TB)(A)(H2A)2(H2O)2(CH3COO)2](CH3COO)2 . 3H2O (C3), where A is H2A without 2 protons. C1-C3 compounds were characterized by standard physico-chemical methods: chemical elemental analysis, IR spectroscopy, UV-Vis-NIR spectroscopy, molar conductivity and thermal analysis. For the obtained C1-C3 complexes, but also for the ligands (H2A and TB) was tested the antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 and antitumor activity on HeLa tumour cells. It has been observed a moderate cytotoxic effect of the complexes C1-C3 on growth and metabolic activity of HeLa cells, while the ligands show a very weak effect on them. The obtained complexes inhibits the adhesion on the substrate of bacterial strains Staphylococcus aureus and Pseudomona aeruginosa, which recommends them for possible therapeutic applications.

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

“…Charge migration facilitates the establishment of a linkage between the two molecules, resulting in modifications of the spectral bands of either the donor or the acceptor [39][40][41]. The significance of charge transfer complexes lies in their wide-ranging utility across multiple domains, including solar energy storage, antimicrobial investigations [36,42], photocatalysis, and microemulsion systems [43][44][45].…”

Insight on Ni(II) and Cu(II) complexes of biguanide derivatives developed as effective antimicrobial and antitumour agents

“…Moreover, species such as [M(Hdmbg) 2 ]X 2 (M: Ni(II), Cu(II), X: CH 3 COO, [10] X: ClO 4 [11] ) and [Cu(Htbg) 2 ]Cl 2 (Htbg: 1-(otolyl)biguanide) [13] proved the ability to inhibit Staphylococcus aureus and Pseudomonas aeruginosa biofilm development on inert substratum. As for complexes with mixed ligands, [Ni(Htbg)(kgl)(H 2 O) 2 ]X (Hkgl: α-ketoglutaric acid; X: Cl, Br) and [Ni(Htbg)(kgl)]X (X: NO 3 , CH 3 COO), [14] they evidenced a good antibiofilm activity against the same strains.…”