Synthesis, Characterization, and Biological Activities of Some 3,5,6‐Trichloropyridine Derivatives.

Chavan, V. P.; Sonawane, S. A.; Shingare, Murlidhar S.; Karale, B. K.

doi:10.1002/chin.200705139

Cited by 3 publications

(4 citation statements)

References 1 publication

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“…Ni(II) complexes showed the magnetic moment values of 3.20 BM consistent with their d 8 (t 2 g 6 eg 2 ) octahedral environment. Cu(II) complexes showed magnetic moments of 1.77 BM, slightly higher than the spin-only value (1.73 BM) expected for one unpaired electron d 9 (t 2 g 6 eg 3 ), offering the possibility of octahedral geometry [21]. These geometries are further confirmed by electronic transitions.…”

Section: Magnetic Moments and Electronic Absorption Spectramentioning

confidence: 92%

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Molecular Modeling and Antimicrobial Screening Studies on Some 3-Aminopyridine Transition Metal Complexes

Moustafa¹,

Mohamed²,

Ibrahim³

2022

OJIC

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Seven transition metal complexes of Mn 2+ , Ni 2+ , Co 2+ , Cu 2+ and Zn 2+ with 3-aminopyridine (3-APy) as ligand have been synthesized, characterized by different techniques and their antibacterial activities were studied. Molecular modeling calculations were performed using DMOL 3 program in materials studio package which is designed for the realization of large scale density functional theory calculation (DFT). The quantum mechanical and chemical reactivity parameters such as chemical hardness, chemical potential, electronegativity, electrophilicity index and Homo-Lumo energy gap were obtained theoretically and were used to understand the biological activity of the prepared compounds. Some complexes were tested for their in-vitro cytotoxic activity in human lung cancer cell lines (A-549 cell line), and structure-activity relationships were established. In general, the coordination to Co 2+ increased the cytotoxicity while the Ni 2+ complexes show reduced cytotoxic activity compared to the metal-free 3-aminopyridine.

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Section: Magnetic Moments and Electronic Absorption Spectramentioning

confidence: 92%

“…The cluster calculations using DMOL 3 program [18] in materials studio package [19] which is designed for the realization of large scale density functional theory calculation (DFT) were performed. DFT semi-core pseudopods calculations (dspp) were performed with the double numerica basis sets plus polarization functional (DNP).…”

Section: Molecular Modelingmentioning

confidence: 99%

Molecular Modeling and Antimicrobial Screening Studies on Some 3-Aminopyridine Transition Metal Complexes

Moustafa¹,

Mohamed²,

Ibrahim³

2022

OJIC

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“…The compound is suspected to be 4-amino-5-cyano-6-(4'methoxyphenyl) -1-methyl-2,3-dihydropyrrolo [2,3-B] pyridine. (Altaf et al, 2015), and as an antifungal agent against Aspergillus niger and Aspergillus teniussiama (Chavan et al, 2006). Octenidiene -a pyridine derivate which comprising hydrophilic and lipophilic parts -as an antimicrobial agent (Savchenko, Dorokhov, Yakushchenko, Zyuzin, & Aldoshin, 2010).…”

Section: Isolation and Partial Purification Of Active Compounds Frommentioning

confidence: 99%

The Potency Of Actinomycetes From Deepsea Sediment Of Makassar Strait For Producing Antimicrobial Substances

Hatmanti

Lisdiyanti

Widada

et al. 2018

Squalen Bull. Marine Fisheries Postharvest Biotech.

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A research on antimicrobial screening of 36 actinomycetes isolated from marine sediment of Makassar Strait through Widya Nusantara Expedition (EWIN) in 2013 and 2014, enzymatic characterization of potential isolates, morphological characterization and metabolite profiling of selected isolates has been conducted. The antimicrobial screening was conducted using paper disc, enzymatic characterization was using APIZYM Kit, morphological characterization was using Scanning Electron Microscope. And metabolite profiling was using TLC and GCMS. Five isolates retrieved from this research had ability to inhibit the growth of the four microbial testing, Escherichia coli, Bacillus subtilis, Staphyllococcus aureus and Candida albicans, and the highest capability was shown by the MACMK-43 isolate that had 16S rRNA gene sequence similarity of 97.85% to Streptomyces violacens. The result showed that in GCMS, the active fraction was contained 4-amino-5-cyano-6-(4'methoxyphenyl)-1-methyl-2.3-dihydropyrrolo [2,3-B] pyridine which commercially used for bactericides and antihistamine.

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“…2 ). Compounds containing the pyridine pattern have a wide range of biological profiles including antimicrobial 31 – 36 , anti-viral 37 , 38 , antioxidant 39 , antidiabetic 40 , anticancer 41 – 43 , anti-inflammatory agents 44 , 45 . For all these benefits related to thiazole and pyridine derivatives and following our work 46 – 50 , we report here the synthesis of a new library of thiazole derivatives from 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2 H )-yl)thiourea 2 .…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents

Khidre

Radini

2021

Sci Rep

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A novel series of substituted 4,6-dimethyl-2-oxo-1-(thiazol-2-ylamino)-1,2-dihydropyridine-3-carbonitrile derivatives 6, 9, 13, 15, and 17 was synthesized in a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)thiourea with 2-oxo-N'-arylpropanehydrazonoyl chloride, chloroacetone, α-bromoketones, ethyl chloroacetate, and 2,3-dichloroquinoxaline, respectively. The potential DNA gyrase inhibitory activity was examined using in silico molecular docking simulation. The novel thiazoles exhibit dock score values between − 6.4 and − 9.2 kcal/mol and they were screened for their antimicrobial activities. Compound 13a shown good antibacterial activities with MIC ranged from 93.7–46.9 μg/mL, in addition, it shown good antifungal activities with MIC ranged from 7.8 and 5.8 μg/mL.

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Synthesis, Characterization, and Biological Activities of Some 3,5,6‐Trichloropyridine Derivatives.

Cited by 3 publications

References 1 publication

Molecular Modeling and Antimicrobial Screening Studies on Some 3-Aminopyridine Transition Metal Complexes

Molecular Modeling and Antimicrobial Screening Studies on Some 3-Aminopyridine Transition Metal Complexes

The Potency Of Actinomycetes From Deepsea Sediment Of Makassar Strait For Producing Antimicrobial Substances

Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents

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