Synthesis, Characterization and Biocidal Evaluation of Azole-Based Ligandsmetal Complexes

Hassan, G. F.

doi:10.3126/ijasbt.v1i4.9176

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…The number of fungal colonies were counted using colony counter. The % inhibition was calculated according to the given formula above [21,22]. Complexes are better antifungal agents than soaps and Neem complex is more effective than Pongamia complex (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

Untitled

2017

GJPPS

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Different methods were applied on Neem and Karanj oils; their Copper (II) soaps and also their Copper (II) soaps benzothiazole complexes to study their comparative fungicidal study. To find the biological activity different methods were used i.e. Antifungal Disk Diffusion Susceptibility Testing of Yeasts; approved Guideline (M 44-A, NCCLS, USA) and antifungal testing of Alternaria alternata suggested by Booth and Hawks worth. The testing was done on two species of Candida i.e. C.albicans and C.krusei. Antimicrobial disks used were Fluconazole, Amphotericin, Clotrimazole and Ketoconazole. These antimicrobial disks were used as standard, as the strains of Candida albicans and Candida krusei are susceptible to them. The diameter of zones of testing disks was compared with the zone diameter of these standards antimicrobial agents.

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Section: Resultsmentioning

confidence: 99%

Untitled

2017

GJPPS

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“…It has also been established that chelation of the nitrogen and sulphur containing compounds and their substituted derivatives enhances the biological and fungicidal activity [22][23][24][25][26]. The use of copper linoleate as heavy-duty wood preservative and other biological activities of surfactants containing copper metal have also been studied [27].…”

Section: Introductionmentioning

confidence: 99%

A Pharmaceutical Approach & Antifungal Activities of Copper Soaps with their N & S Donor Complexes Derived from Mustard and Soyabean Oils

Sharma¹

2017

GJPPS

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Fungicidal studies have also been done so as to understand the toxicity patterns of Copper-Mustard soap, Copper-Soyabean soap and their complexes on Alternaria alternata fungi at varying concentrations using agar plate technique. The effect of solvent has been excluded by complete evaporation. Fungicidal activity is measured in terms of % inhibition. The % Inhibition is calculated according to the following equation: -% Inhibition = (C-T) /C *100Where C and T are the diameter of fungal colony in control plate and test plate respectively after 72 hours. In general, it has also been concluded that CMU complexes are more active than CSU complexes. All the physico-chemical and fungicidal analysis reported by us will play a significant role in their application in industries and various other fields.

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“…Such copper complexes are applied in various activities such as anticancer, anti tubercular, antibiotic, antimicrobial and antifungal, anticonvulsant, analgesic and anti-inflammatory anti-protozoal, anti-helmintics, anti-HIV, antihepatic, antiulcer activities, antibacterial, antimalarial, anti-allergic, antibiotic etc agents [5][6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

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2015

IJPSR

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Biologically potent compounds are one of the most important classes of materials for the upcoming generations. Increasing number of microbial infectious diseases and resistant pathogens create a demand and urgency to develop novel, potent, safe and improved variety of antimicrobial agents. This initiates a task for current chemistry to synthesize compounds that show promising activity as therapeutic agents with lower toxicity. Therefore, a substantial research is needed for their discovery and improvement. Transition metal complexes share an important place in this regards. Further, it is evidenced that complexation of above metal ions with nitrogen and sulphur donor ligands increases the efficiency of biocidal activity. For the same, metallic soaps of copper (derived from common fatty acids) were complexed with substituted 2-amino benzothiazole derivatives. Complexes were characterized by elemental analysis IR, NMR and ESR spectral data. Their purity was checked by Thin Layer Chromatography. Their antimicrobial efficacy / biological activity was examined against selective bacteria such as Pseudomonas aeruginosa (Gram negative), Lactobacillus aciedophillus (Gram positive), antifungal activity against Fusarium semitectum and Trichophyton ruburum by Kirby-Bauer and Stokes' method. The transition metal complexes showed good antibacterial and antifungal activity than the free ligands because chelation increases the anti-microbial potency.

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Synthesis, Characterization and Biocidal Evaluation of Azole-Based Ligandsmetal Complexes

Cited by 3 publications

References 4 publications

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A Pharmaceutical Approach & Antifungal Activities of Copper Soaps with their N & S Donor Complexes Derived from Mustard and Soyabean Oils

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