Synthesis, characterization and bio-activity of nickel(II) and copper(II) complexes of a bidentate NS Schiff base of S-benzyl dithiocarbazate

Zangrando, Ennio; Islam, Md. Tariqul; Sheikh, Md. Chanmiya; Tarafder, M. T. H.; Miyatake, Ryuta; Zahan, Ronok; Hossain, M. Mahmun

doi:10.1016/j.ica.2014.12.014

Cited by 76 publications

(37 citation statements)

References 35 publications

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“…Early phase of this model is attributed to release of bradykinin, histamine, serotonin, and prostaglandins synthesis in surroundings of damaged tissue. The late phase is sustained by prostaglandins release and mediated by leukotrienes, bradykinin, and polymorphonuclear cells [23][24][25] . The anti-inflammatory data (Table 2) indicate that carrageenan-induced edema is significantly inhibited by tested compounds in late phase.…”

Section: S C H E M Ementioning

confidence: 99%

Screening of curcumin‐derived isoxazole, pyrazoles, and pyrimidines for their anti‐inflammatory, antinociceptive, and cyclooxygenase‐2 inhibition

et al. 2017

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Curcumin has shown pharmacological properties against different phenotypes of various disease models. Different synthetic routes have been employed to develop its numerous derivatives for diverse and improved therapeutic roles. In this study, we have synthesized curcumin derivatives containing isoxazole, pyrazoles, and pyrimidines and then the synthesized molecules were evaluated for their anti-inflammatory and antinociceptive activities in experimental animal models. Acute toxicity of synthesized molecules was evaluated in albino mice by oral administration. Any behavioral and neurological changes were observed at dose of 10 mg/kg body weight.Additionally, cyclooxygenase-2 (COX-2) enzyme inhibition studies were performed through in vitro assays. In vivo anti-inflammatory studies showed that curcumin with pyrimidines was the most potent anti-inflammatory agent which inhibited induced edema from 74.7% to 75.9%. Compounds 7, 9, and 12 exhibited relatively higher prevention of writhing episodes than any other compound with antinociceptive activity of 73.2%, 74.9%, and 71.8%, respectively. This was better than diclofenac sodium (reference drug, 67.1% inhibition). Similarly, COX-2 in vitro inhibition assays results revealed that compound 12 (75.3% inhibition) was the most potent compound.Molecular docking studies of 10, 11, and 12 compounds in human COX-2 binding site revealed the similar binding modes as that of other COX-2-selective inhibitors. K E Y W O R D Santi-inflammatory, COX-2 inhibition, curcumin derivatives, molecular modeling Chemically curcumin is diferuloylmethane which has attracted much attention of medicinal chemists for various diseases and therapeutic agents development. It has shown its pharmacological safety and wide range of biological activities such as antibacterial to anticancer agent [1][2][3][4] . Currently, curcumin is acclaimed to be one of the most widely researched naturally occurring chemopreventive agent which is cytoprotective to healthy human cells [5][6][7] . In spite of important therapeutic application, limited therapeutic utility concerns are associated with curcumin because of its poor absorption and fast metabolism under physiological conditions [8] . Active methylene and keto moiety are believed to be responsible for its rapid metabolism. In order to circumvent the problem of rapid metabolism and to improve its pharmacokinetics profile, several synthetic modifications have been studied on carbonyl and active methylene moiety [9] . In present study, isoxazole, N-substituted pyrazoles, and pyrimidine ring were incorporated in this focused segment of curcumin. Nitrogen heterocyclic moieties such as pyrazoles and pyrimidines containing derivatives gained considerable attention in medicinal chemistry for

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Section: S C H E M Ementioning

confidence: 99%

Screening of curcumin‐derived isoxazole, pyrazoles, and pyrimidines for their anti‐inflammatory, antinociceptive, and cyclooxygenase‐2 inhibition

et al. 2017

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“…It is reported that the amine-and thione-substituted triazoles, derived by the condensation of the derivatives of 1,2,4-triazine and the aldehyde or ketone, exhibited a strong affinity to some metal ions, such as Cu(II), Zn(II), Pb(II), Cr(III), Co(II), Ni(II), Mn(II) and Fe(II) [11,15,20]. When the ligands reacted with metal ions in aqueous solutions, its thione functional group rearranged to form thiol, thus allowing the bidentate coordination to metal ions through S and N atom to form a stable five-membered ring while releasing H ions into aqueous solutions [20][21][22][23]. The powerful affinity of S and N atoms to transition metal ions rendered a potential application of these compounds in modulating the surface of sulfide minerals.…”

Section: Introductionmentioning

confidence: 99%

Separation of Molybdenite from Chalcopyrite in the Presence of Novel Depressant 4-Amino-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one

Yin

Sun

et al. 2017

Minerals

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Abstract:In this paper, 4-amino-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one (ATDT) was synthesized and introduced as a depressant for selective flotation separation of molybdenite from chalcopyrite. Its flotation performance and adsorption mechanism on minerals were first investigated by flotation, UV spectra, zeta potential, Fourier Transform Infrared Spectroscopy (FT-IR), and X-ray Photoelectron Spectroscopy Measurements (XPS). The bench scale tests indicated that ATDT exhibited stronger depressing power than chalcopyrite, and the selective index of Mo/Cu improved significantly in the presence of ATDT. The results of the UV spectra, zeta potential and FT-IR demonstrated that ATDT chemisorbed on the chalcopyrite surface. The XPS results further confirmed that ATDT might chemisorb onto the chalcopyrite surface through S and N atoms to form five-membered chelate rings and a postulated adsorption mode was presented. For molybdenite, the different measurements agreed well with each other and implied that ATDT might weakly physisorb onto a molybdenite surface.

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“…Many metal complexes with transition metals as center ions show excellent antibacterial and antitumor activities, such as Cu(II) [1][2][3], Zn(II) [4][5][6], Mn(II) [7][8][9], Ni(II) [10][11][12], Ag(I) [13][14][15], and so on. Meanwhile, hydrazone compounds also exhibit good biological activities and are a kind of good ligand [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…The investigations of the synthesis and properties of Ca(II) complexes have always been one of our goals [19][20][21][22][23][24][25]. In this work, we synthesized a novel eight-coordinated dinuclear Ca(II) complex, [Ca 2 (L) 2 (H 2 O) 10 ]·H 2 O (1), by the reaction of 3-pyridinecarboxylic hydrazide, disodium 4-formylbenzene-1,3-disulfonate, and Ca(ClO 4 ) 2 ·4H 2 O. Complex 1 was characterized by elemental analysis, IR spectrum, 1 H-NMR, 13 C-NMR, and single crystal X-ray crystallography.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex

2016

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Abstract:A novel eight-coordinated dinuclear Ca ( , µ = 0.572 mm −1 , F(000) = 552, and final R 1 = 0.0308, ωR 2 = 0.0770. Dinuclear Ca(II) molecules form a 1D chained structure by π-π stacking interaction. The 1D chains form a 3D framework structure by the π-π stacking interaction and hydrogen bonds. The in vitro cytotoxic activity activity of 1 against HL-60 and MLTC-1 was also investigated.

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Synthesis, characterization and bio-activity of nickel(II) and copper(II) complexes of a bidentate NS Schiff base of S-benzyl dithiocarbazate

Cited by 76 publications

References 35 publications

Screening of curcumin‐derived isoxazole, pyrazoles, and pyrimidines for their anti‐inflammatory, antinociceptive, and cyclooxygenase‐2 inhibition

Screening of curcumin‐derived isoxazole, pyrazoles, and pyrimidines for their anti‐inflammatory, antinociceptive, and cyclooxygenase‐2 inhibition

Separation of Molybdenite from Chalcopyrite in the Presence of Novel Depressant 4-Amino-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one

Synthesis, Crystal Structure, and Cytotoxic Activity of a Novel Eight-Coordinated Dinuclear Ca(II)-Schiff Base Complex

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