Synthesis, Characterization and Bilogical Screening of Some Novel Indole Based 1,2,4-Triazolo 1,3,4-Thiadiazines

Mekala, Raghu Vardhan Reddy; Yata, Mahipal Reddy; Talagadadivi, Ravi Prasad

doi:10.22270/jddt.v4i2.786

Cited by 2 publications

(3 citation statements)

References 4 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, compound 59 has moderate nematicidal activity against Ditylenchus myceliophagus and C. elegans with LC 50 values of 170 and 190 mg/L, respectively. 139 The LC 50 values of compound 60 for D. myceliophagus and C. elegans were 220 and 270 mg/L, respectively. 140 The LD 50 value of compound 63 was 50 μM.…”

Section: ■ Data Sourcesmentioning

confidence: 97%

“…At present, there are a few reports on the design, synthesis, and nematicidal activity of tioxazafen analogs. For example, compound 59 has moderate nematicidal activity against Ditylenchus myceliophagus and C. elegans with LC 50 values of 170 and 190 mg/L, respectively . The LC 50 values of compound 60 for D. myceliophagus and C. elegans were 220 and 270 mg/L, respectively .…”

Section: Chemical Nematicidal Active Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Nematicides: Recent Research Progress and Outlook

Chen

Song

2020

J. Agric. Food Chem.

123

View full text Add to dashboard Cite

Plant-parasitic nematodes have caused huge economic losses to agriculture worldwide and seriously threaten the sustainable development of modern agriculture. Chemical nematicides are still the most effective means to manage nematodes. However, the long-term use of organophosphorus and carbamate nematicides has led to a lack of field control efficacy and increased nematode resistance. To meet the huge market demand and slow the growth of resistance, new nematicides are needed to enter the market. The rational design and synthesis of new chemical scaffolds to screen for new nematicides is still a difficult task. We reviewed the latest research progress of nematicidal compounds in the past decade, discussed the structure−activity relationship and mechanism of action, and recommended some nematicidal active fragments. It is hoped that this review can update the recent progress on nematicide discoveries and provide new ideas for the design and mechanism of action studies of nematicides.

show abstract

Section: ■ Data Sourcesmentioning

confidence: 97%

Section: Chemical Nematicidal Active Compoundsmentioning

confidence: 99%

Chemical Nematicides: Recent Research Progress and Outlook

Chen

Song

2020

J. Agric. Food Chem.

123

View full text Add to dashboard Cite

show abstract

“…In addition, due to the polar nature of the structure, the triazole moiety can increase the solubility of the ligand and thereby the pharmacokinetic profile of the drug is positively affected. 1,2,4-triazolo [3,4-b] [1,3,4] thiadiazine derivatives have been reported in the literature by their antimicrobial 1,4,7,8,9,10,11,14,15,17,18 , antifungal 8,13 , molluscicidal 6 and nematicidal 13,14 , analgesic 3,16 , anti-inflammatory 3,6,11,16 , anticancer 2,8,16 , phosphodiesterase-4 inhibitor 5 , acetylcholinesterase 12 , butyrylcholinesterase 12 and alkaline phosphatase 12 inhibitor activity. Due to the wide pharmacological effect of 1,2,4-triazolo [3,4-b][1,3,4]thiadiazine derivatives researchers are interested in the synthesis of novel compounds bearing the 1,2,4-triazolo [3,4- 3,4]thiadiazine ring structure are disclosed in the literature as antimicrobial, antifungal, molluscicidal and nematicidal, analgesic, anti-inflammatory, anticancer, phosphodiesterase-4 inhibitor, acetylcholinesterase, butyrylcholinesterase and alkaline phosphatase inhibitor agents.…”

Section: Introductionmentioning

confidence: 99%

Discovery, Synthesis and Activity Evaluation of Novel Compounds Bearing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine Moiety: A Review

Dincel¹,

Güzeldemirci²

2019

JARHS

View full text Add to dashboard Cite

Lately, much interest has been focused on the chemistry and the biological activity of fused heterocyclic compounds carrying nitrogen atoms because of their utility in various applications, and over the years N-bridged heterocyclic systems derived from 1,2,4-triazoles attracted the interest of researchers owing to the hopeful promise of their pharmacological activities such as antimicrobial, antifungal, molluscicidal, nematicidal, analgesic, anti-inflammatory, anticancer, phosphodiesterase 4 inhibitor, acetylcholinesterase, butyrylcholinesterases and alkaline phosphatase inhibitor. The fused ring of triazole and thiadiazines, named as triazolothiadiazines, represents a specific and important class of N-bridged heterocycles with their remarkable and wide range of biological activity and there are not enough studies that include the current developments associated with the new synthesis techniques and novel biological evaluation results of 1,2,4-triazolo[3,4-b][1,3,4] thiadiazine derivatives. In an attempt to overcome this deficiency in the literature, we deeply researched the literature and formed a review study about the discovery, synthesis and activity evaluation of new compounds bearing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine moiety within the years of 1996-2019. We aimed to provide scientists with a wide data resource about 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine derivatives, thus helping them perform a more organized and fertile drug discovery operation during their experimental studies. ÖZSon zamanlarda, geniş ölçekte çeşitlilik gösteren uygulamalardaki kullanımları nedeniyle azot atomu taşıyan kaynaşmış heterosiklik bileşiklerin kimyası ve biyolojik aktivitesi üzerine olan ilgi artmış ve yoğunlaşmıştır. Yıllar boyunca 1,2,4-triazollerden türetilen azot köprülü heterosiklik sistemler antimikrobiyal, antifungal, mollusisidal, nematisidal, analjezik, anti-inflamatuvar, antikanser, fosfodiesteraz-4 inhibitörü, asetilkolinesteraz, butirilkolinesteraz ve alkalen fosfataz inhibitörü gibi farklı biyolojik yönlerde, umut vadeden farmakolojik aktiviteler göstermiş ve buna bağlı olarak araştırmacıların ilgisini çekmiştir. Triazol ve tiyadiazin halkalarının kaynaşmasıyla oluşan triazolotiyadiazinler azot köprülü heterosiklik bileşikler arasında önemli ve dikkat çekici bir alt sınıfı oluşturmaktadır, buna karşın 1,2,4-triazolo [3,4-b][1,3,4]tiyadiazin türevlerinie ait güncel sentez teknikleri ve yeni biyolojik aktivite bulgularını içeren çalışmalar literatürde yeterli oranda bulunmamaktadır. Bu noktadan hareketle 1996-2019 tarih aralığını referans alarak 1,2,4-triazolo [3,4-b] [1,3,4] tiyadiazin yapısı taşıyan yeni bileşiklerin keşfi, sentezi ve aktivite değerlendirmeleri ile ilişkili bir derleme çalışması yürütülmüştür. Araştırmacıların daha organize ve verimli bir ilaç keşif prosesi gerçekleştirmelerine yardımcı olmak amaçlanmıştır.

show abstract

Synthesis, Characterization and Bilogical Screening of Some Novel Indole Based 1,2,4-Triazolo 1,3,4-Thiadiazines

Cited by 2 publications

References 4 publications

Chemical Nematicides: Recent Research Progress and Outlook

Chemical Nematicides: Recent Research Progress and Outlook

Discovery, Synthesis and Activity Evaluation of Novel Compounds Bearing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine Moiety: A Review

Contact Info

Product

Resources

About