Synthesis, Characterization and Applications of a Novel Platinum-Based Nanoparticles: Catalytic, Antibacterial and Cytotoxic Studies

Safdar, Muhammad; Özaslan, Mehmet; Khailany, Rozhgar A.; Latif, Sehrish; Junejo, Yasmeen; Saeed, Muhammad; Al-Attar, Mustafa S.; Kanabe, Belan O.

doi:10.1007/s10904-019-01387-7

Cited by 20 publications

(17 citation statements)

References 34 publications

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“…57,58 In the literature, the bacteria killing mechanism is most frequently related to the disruption on the bacterial cell membrane and to the release of metal ions. It has been observed by Safdar et al 59 that small nanoparticles (2-5 nm in size) are more effective against bacterial growth and show the inhibiting activity with the maximal zone of inhibition against Grampositive bacteria. In contrast, Ramkumar et al 60 have found significantly smaller effect on the growth of Grampositive bacteria as compared to Gram-negative bacteria.…”

Section: Resultsmentioning

confidence: 99%

Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO₂ under high pressure

Пигалева

Novikov

Nikolaev

et al. 2020

J of Applied Polymer Sci

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The creation of biocompatible composite hydrogels from renewable biopolymers with stabilized functional platinum nanoparticles seems to be an important scientific task. The formation of such hydrogels in a unique medium of carbonic acid under high pressure CO 2 is promising due to its sterilizing ability under pressure, biocompatibility after decompression and environmental friendliness. In the present work, stable chitosan hydrogels with platinum nanoparticles were obtained in such solutions. The hydrogel nature of the composites was confirmed by rotational rheology. The physicochemical characteristics were studied using Fourier transform infrared, X-ray photoelectron, ultraviolet-visible spectroscopies, transmission electron, scanning electron and atomic force microscopies. It was found that nanoparticles of oxidized Pt of approximately 4.5 nm in size are stabilized by chitosan in the composite. The resulting chitosan/Pt hydrogels were also tested for antimicrobial activity and shown strong activity against Gram-positive bacteria (B. subtilis and B. coagulans) and slight activity against E. coli.

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Section: Resultsmentioning

confidence: 99%

Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO₂ under high pressure

Пигалева

Novikov

Nikolaev

et al. 2020

J of Applied Polymer Sci

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“…In addition, these newly synthesized NPs were evaluated against anticancer (SKBR3 cells) and antimicrobial activities (E. coli and A. flavus). AuNPs were synthesized using protocol [21,22]. The mean diameter of NPs was about 10-20 nm.…”

Section: Methodsmentioning

confidence: 99%

“…3. A number of methods have been reported for synthesis of Au(0) NPs and characterized by TEM [21,23]. These smaller monodispersed nanospheres promise superior anticancer and antibacterial activities for some specific applications.…”

Section: High Resolution Transmission Electron Microscopy (Hr-tem) Analysismentioning

confidence: 99%

“…Nanoparticles particularly gold nanoparticles showed high potenitial to be employed for multiple applications. So we thought that newly synthesized gold nanoparticles may inhibit the ROCK pathway via the ATP-dependent kinase domain [19][20][21]. However, to our knowledge, there is no study available in the literature which has been done to investigate the relationship between the TRP channels after the treatment of doxy-Au(0) NPs.To confirm the hypothesis, we were aiming to study the outcome of the doxy-Au(0) NPs (50 and 100 lg/ mL) on the expression levels of TRP genes in the SKBR3 breast cancer line and CRL-4010mammary epithelial cell line (as a control) as well as antimicrobial studies were done for evalution of these multiple use.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Employed Doxycycline Capped Gold Nanoparticles on TRP Channel Expressions in SKBR3 Breast Cancer Cells and Antimicrobial Activity

2021

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Doxycycline capped gold nanoparticles (doxy-Au(0) NPs) were prepared in an aqueous medium. Particle size and shape were determined by Transmission electron microscopy which showed the monodispersed morphology. The Fourier transform infrared spectra were represented the interaction of doxycycline with surface of doxy-Au(0) NPs. X-ray powder diffraction study gave crystalline nature of the doxy-Au(0) NPs. These doxy-Au(0) NPs have an impact on the expression levels of TRP channel genes in the breast cancer line (SKBR3) and the breast epithelial cell line (CRL-4010). Additionally, the antimicrobial activities have been evaluated to be used for multiple applications. Our results showed that the expression levels of TRP genes can be changed following the treatment of AuNPs (50 and 100 lg/mL). Furthermore, the antimicrobial activies have achieved some significant results. Finally, it has been concluded that doxy-Au(0) NPs are novel and can be used as alternative nanomedicine and extendable for control of other reducible contaminants as well.

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“…Many of the medicinal residues in water, sewage, and pigments in the water line are considered as severe threats to human health [ 6 , 7 ]. Environmental inorganic and organic pollution, created by industries, is a primary concern for human-race and public health because of contaminated foods and waters.…”

Section: Introductionmentioning

confidence: 99%

Novel Pt-Ag3PO4/CdS/Chitosan Nanocomposite with Enhanced Photocatalytic and Biological Activities

et al. 2020

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Decorating photocatalysts with noble metal nanoparticles (e.g., Pt) often increases the catalysts’ photocatalytic activity and biomedical properties. Here, a simple and inexpensive method has been developed to prepare a Pt-Ag3PO4/CdS/chitosan composite, which was characterized and used for the visible light-induced photocatalytic and antibacterial studies. This synthesized composite showed superior photocatalytic activity for methylene blue degradation as a hazardous pollutant (the maximum dye degradation was observed in 90 min of treatment) and killing of Gram positive bacterial (Staphylococcus aureus and Bacillus cereus) as well as Gram negative bacteria (Klebsiella pneumoniae, Salmonella typhimurium, Escherichia coli, and Pseudomonas aeruginosa) under visible light irradiation. The antibacterial activity of CdS, CdS/Ag3PO4, and Pt-Ag3PO4/CdS/chitosan against E. coli, Pseudomonas aeruginosa, Salmonella typhimurium, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus cereus showed the zone of inhibition (mm) under visible light and under dark conditions at a concentration of 20 µg mL−1. Furthermore, the cell viability of the CdS/chitosan, Ag3PO4, Ag3PO4/CdS/chitosan, and Pt-Ag3PO4/CdS/chitosan were investigated on the human embryonic kidney 293 cells (HEK-293), Henrietta Lacks (HeLa), human liver cancer cell line (HepG2), and pheochromocytoma (PC12) cell lines. In addition, the results indicated that the photodegradation rate for Pt-Ag3PO4/CdS/chitosan is 3.53 times higher than that of CdS and 1.73 times higher than that of the CdS/Ag3PO4 composite. Moreover, Pt-Ag3PO4/CdS/chitosan with an optimal amount of CdS killed large areas of different bacteria and different cells separately in a shorter time period under visible-light irradiation, which shows significantly higher efficiency than pure CdS and other CdS/Ag3PO4 composites. The superb performances of this composite are attributed to its privileged properties, such as retarded recombination of photoinduced electron/hole pairs and a large specific surface area, making Pt-Ag3PO4/CdS/chitosan a valuable composite that can be deployed for a range of important applications, such as visible light-induced photocatalysis and antibacterial activity.

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Synthesis, Characterization and Applications of a Novel Platinum-Based Nanoparticles: Catalytic, Antibacterial and Cytotoxic Studies

Cited by 20 publications

References 34 publications

Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO₂ under high pressure

Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO₂ under high pressure

Synthesis, Characterization and Employed Doxycycline Capped Gold Nanoparticles on TRP Channel Expressions in SKBR3 Breast Cancer Cells and Antimicrobial Activity

Novel Pt-Ag3PO4/CdS/Chitosan Nanocomposite with Enhanced Photocatalytic and Biological Activities

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Synthesis, Characterization and Applications of a Novel Platinum-Based Nanoparticles: Catalytic, Antibacterial and Cytotoxic Studies

Cited by 20 publications

References 34 publications

Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO2 under high pressure

Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO2 under high pressure

Synthesis, Characterization and Employed Doxycycline Capped Gold Nanoparticles on TRP Channel Expressions in SKBR3 Breast Cancer Cells and Antimicrobial Activity

Novel Pt-Ag3PO4/CdS/Chitosan Nanocomposite with Enhanced Photocatalytic and Biological Activities

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Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO₂ under high pressure

Platinum cross‐linked chitosan hydrogels synthesized in water saturated with CO₂ under high pressure