Synthesis, characterization and application of new imino-functionalized 1,3-diazolium salts as antimicrobial agents

Kadafour, Attahir N.W.; Ibrahim, Halliru; Bala, Muhammad D.

doi:10.1016/j.molstruc.2022.132997

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…In this sense, if we compare the MIC values of known antibiotics for the same strain of S. aureus such as ciprofloxacin (0.04 μg/mL), as well as ampicillin (4 μg/mL) and chloramphenicol (75 μg/mL) that were used as positive controls, evidently MAnT is superior in activity. − …”

Section: Resultsmentioning

confidence: 99%

Tetrandrine Derivatives as Promising Antibacterial Agents

et al. 2023

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This work reports on the antibacterial activity of two tetrandrine derivatives, with acridine (MAcT) and anthracene (MAnT) units, against Gram-positive and Gram-negative bacteria of clinical importance by the broth microdilution method as well as their antioxidant activity against ABTS •+ and DPPH •+ radicals. Unlike natural tetrandrine, its derivatives inhibited bacterial growth, showing selectivity against Staphylococcus aureus with notable activity of MAnT (MIC = 0.035 μg/mL); this compound also has good activity against the ABTS •+ radical (IC 50 = 4.59 μg/mL). Cell membrane integrity studies and reactive oxygen species (ROS) detection by fluorescent stains helped to understand possible mechanisms related to antibacterial activity, while electrophoretic mobility assays showed that the derivatives can bind to bacterial DNA plasmid. The results indicate that MAnT can induce a general state of oxidative stress in S. aureus and Escherichia coli, while MAcT induces an oxidative response in S. aureus. Complementary electrochemical studies were included.

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Section: Resultsmentioning

confidence: 99%

Tetrandrine Derivatives as Promising Antibacterial Agents

et al. 2023

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“…13 Bala and co-workers also targeted membrane disruption as a mode of antimicrobial action when developing a series of imino-functionalised 1,3-diazolium salts, demonstrating similar levels of antimicrobial activity to that of antibiotics gentamicin and kanamycin against both methicillin sensitive Staphylococcus aureus (S. aureus) and MRSA. [14][15][16] Naturally derived antimicrobial peptides (AMPs) self-assemble to form larger structures that have intrinsic antimicrobial properties. [17][18][19] The AMPs overall positive charge created due to the presence of cationic amino acid residues, causes these compounds to interact with negatively charged bacterial membranes.…”

Section: Introductionmentioning

confidence: 99%

Controlling the structure of supramolecular fibre formation for benzothiazole based hydrogels with antimicrobial activity against methicillin resistantStaphylococcus aureus

et al. 2023

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Piperazinium Poly(Ionic Liquid)s as Solid Electrolytes for Lithium Batteries

Gallastegui,

Lingua,

Lopez‐Larrea

et al. 2024

Macromol. Rapid Commun.

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Poly(ionic liquid)s combine the unique properties of ionic liquids (ILs) within ionic polymers holding significant promise for energy storage applications. It is reported here the synthesis and characterization of a new family of poly(ionic liquid)s synthesized from cationic piperazinium ionic liquid monomers. The cationic poly(acrylamide piperazinium) in combination with sulfonamide anions like bis(trifluoromethanesulfonyl) imide (TFSI) and bis(fluorosulfonyl) imide (FSI) are characterized as solid polymer electrolytes. The polymer electrolytes in combination with pyrrolidonium ILs and LiFSI show high ionic conductivity, 5×10−3 S cm−1 at 100 °C. Piperazinium polymer electrolytes show excellent compatibility with lithium metal reversible plating and stripping at high current density and low temperature 40 °C.

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Synthesis, characterization and application of new imino-functionalized 1,3-diazolium salts as antimicrobial agents

Cited by 3 publications

References 68 publications

Tetrandrine Derivatives as Promising Antibacterial Agents

Tetrandrine Derivatives as Promising Antibacterial Agents

Controlling the structure of supramolecular fibre formation for benzothiazole based hydrogels with antimicrobial activity against methicillin resistantStaphylococcus aureus

Piperazinium Poly(Ionic Liquid)s as Solid Electrolytes for Lithium Batteries

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