Synthesis, characterization and antitumoral activity of new cobalt(II)complexes: Effect of the ligand isomerism on the biological activity of the complexes

Morcelli, Samila R.; Bull, Érika Soares; Terra, Wagner da Silva; Moreira, Rafaela Oliveira; Borges, Franz Viana; Kanashiro, Milton; Bortoluzzi, Adaílton J.; Maciel, Leide Laura Figueiredo; Almeida, João Carlos de Aquino; Horn, Adolfo; Fernandes, Christiane

doi:10.1016/j.jinorgbio.2016.05.003

Cited by 26 publications

(7 citation statements)

References 25 publications

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“…Our group has been evaluating the cytotoxic activities of a series of coordination compounds containing different metal ions both in vitro and in vivo [ 20 , 21 , 22 , 23 , 24 ]. We previously showed the synthesis, characterization, and cytotoxic activity of four complexes containing platinum(II) as a metallic coordinating center ( Scheme 1 ), where treatment against U937 cell line with complex ( 3 ) [Pt(HL3)Cl]·H 2 O could induce the activation of both intrinsic and extrinsic apoptotic cascades, as well as perturbations in cell cycle and dysfunction of mitochondrial membrane potential [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Relevant Antineoplastic Activity of Platinum(II) Complexes toward Triple-Negative MDA-MB-231 Breast Cancer Cell Line

Maciel

Silva

Moreira³

et al. 2022

Pharmaceutics

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Two platinum complexes [Pt(HL3)Cl]·H2O (3) and [Pt(HL4)Cl]·H2O (4) containing α- and β-naphthyl groups, respectively, were investigated in more detail in vitro and in vivo for antineoplastic activity. The cytotoxicity activity induced by these platinum(II) compounds against breast cancer (MDA-MB-231 and MCF-7), lung (A549), prostate (PC3), pancreas (BXPC-3), and normal peripheral blood mononuclear (PBMC) cells were evaluated by MTT assay. The cell viability MTT assay showed that complex (4) was more cytotoxic to all cancer cell lines tested and less cytotoxic against human PBMC. Therefore, complex (4) was selected to further investigate the mechanism of cytotoxic effects involved against MDA-MB-231 cell line (human triple-negative breast cancer). Sub-G1 analysis of the cell cycle showed that this complex induces cell death by apoptosis due to the cell loss of DNA content detected in flow cytometry. The cytotoxic effect induced by complex (4) was associated with the capability of the complex to induce mitochondrial membrane depolarization, as well as increase ROS levels and caspase activation, as a result of the activation of both extrinsic and intrinsic apoptosis pathways. Ultrastructural alterations were observed using scanning and transmission electron microscopy (SEM and TEM), such as membrane blebbing, filopodia reduction, empty mitochondrial matrix, and DNA fragmentation. Furthermore, complex (4) was tested in an MDA-MB-231 tumor nodule xenograft murine model and demonstrated a remarkable reduction in tumor size in BALB/c nude mice, when compared to the control animals.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Relevant Antineoplastic Activity of Platinum(II) Complexes toward Triple-Negative MDA-MB-231 Breast Cancer Cell Line

Maciel

Silva

Moreira³

et al. 2022

Pharmaceutics

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“…The pro-apoptotic effect of cobalt complexes on tumor cells could open a new perspective for the use of these compounds as anti-tumor agents [ 38 , 39 , 40 , 41 , 42 ]. The design of new metal-based anticancer drugs is taken into consideration in order to enhance the selectivity through various non-covalent binding interactions such as intercalation or electrostatic binding, so the cobalt(II) complexes with dmtp could exhibit an anticancer potential considering the redox-activity of Co(II) that may damage DNA by inducing oxidative stress and/or producing DNA modifications by coordination while the ligand could both intercalate and generate hydrogen bonds with nucleotides.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

et al. 2017

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Three complexes, namely [Co(dmtp)2(OH2)4][CoCl4] (1), [Co(dmtp)2Cl2] (2) and [Co(dmtp)2(OH2)4]Cl2∙2H2O (3) (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine), were synthesized and characterized by spectral (IR, UV-Vis-NIR), and magnetic measurements at room temperature, as well as single crystal X-ray diffraction. Complex (1) crystallizes in monoclinic system (space group C2/c), complex (2) adopts an orthorhombic system (space group Pbca), and complex (3) crystallizes in triclinic system (space group P1¯). Various types of extended hydrogen bonds and π–π interactions provide a supramolecular architecture for all complexes. All species were evaluated for antimicrobial activity towards planktonic and biofilm-embedded microbial cells and influence on HEp-2 cell viability, cellular cycle and gene expression.

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“…[36]. Structures of complexes (2) and (3) involved the naphthyl group and contained α and β-naphthyl groups, respectively.…”

Section: Synthesized New Cobalt Compoundsmentioning

confidence: 99%

“…Moreover, complexes (2) and (3) paved the way for the death of cancer cells without affecting the normal cells. In this chapter, it is significant to determine the kind of the structure of the ligand and the kind of metal center on cytotoxicity [36]. Table 3.…”

Section: Synthesized New Cobalt Compoundsmentioning

confidence: 99%

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General Aspects of the Cobalt Chemistry

Yıldız¹

2017

Cobalt

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This chapter aims to collect and summarize the chemical properties of cobalt and some new cobalt compounds. It deals with the progress of cobalt chemistry. Cobalt has been substantial in both chemical reactions and within many compounds. Some of them are heterocyclic reactions, cobalt-based catalyst and cobalamin. Also, it discusses variety of applications of cobalt in a wide range of areas and toxicity of cobalt. The studies carried out in this area so far have enabled and will be continued to be responsible for producing unknown and difficult reactions. This survey of the recent literature illustrates the fact that many different approaches on cobalt and new cobalt compounds are being used in many different areas.

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Synthesis, characterization and antitumoral activity of new cobalt(II)complexes: Effect of the ligand isomerism on the biological activity of the complexes

Cited by 26 publications

References 25 publications

In Vitro and In Vivo Relevant Antineoplastic Activity of Platinum(II) Complexes toward Triple-Negative MDA-MB-231 Breast Cancer Cell Line

In Vitro and In Vivo Relevant Antineoplastic Activity of Platinum(II) Complexes toward Triple-Negative MDA-MB-231 Breast Cancer Cell Line

Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

General Aspects of the Cobalt Chemistry

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