Synthesis, characterization and antitumor activity of two new dipyridinium ylide based lanthanide(III) complexes

Cârâc, Andreea; Boscencu, Rica; Dinică, Rodica Mihaela; Guerreiro, Joana F.; Silva, Francisco; Campello, Maria Paula Cabral; Moïse, C.; Brîncoveanu, Oana; Enăchescu, Marius; Cârâc, Geta; Tăbăcaru, Aurel

doi:10.1016/j.ica.2018.05.003

Cited by 14 publications

(4 citation statements)

References 47 publications

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“…In recent years, high interaction between lanthanides as a ligand and macromolecules was reported. Also, the wide application of complexes containing these metals has been proved in radio Immunotherapy, antimicrobial, antitumor, and fungicidal drugs ( Fricker, 2006 ; Thompson and Orvig 2006 ; Kostova and Stefanova, 2010 ; Amoroso and Pope, 2015 ; Cârâc et al, 2018 ; He et al, 2019 ). 1, 10-phenanthroline is one of the most important agents in the chelating class.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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To learn more about the chemotherapeutic and pharmacokinetic properties of a neodymium complex containing 1,10-phenanthroline (dafone), In vitro binding was investigated with bovine serum albumin and fish-salmon DNA, using a variety of molecular modeling research and biophysical approaches. A variety of spectroscopic techniques including fluorescence and absorption were used to investigate the interplay between DNA/BSA and the neodymium complex. The findings revealed that the Nd complex had a high affinity for BSA and DNA interplays through van der Waals powers. In addition, the binding of the Nd complex to FS-DNA mainly in the groove binding mode clearly reflects with iodide quenching studies, ethidium bromide (EtBr) exclusion assay, ionic strength effect, and viscosity studies. It was observed that the Nd complex binds to FS-DNA through a minor groove with 3.81 × 105 (M−1). Also, Kb for BSA at 298 K was 5.19×105 (M−1), indicating a relatively high affinity of the Nd complex for DNA and BSA. In addition, a competitive study of a docking investigation revealed that the neodymium complex interacts at BSA site III. The results obtained from the binding calculations are well consistent with the experimental findings. Also, cytotoxicity studies of Nd complex were performed in MCF-7 and A-549 cell lines and the results show that this new complex has a selective inhibitory effect on the growth of various cancer cells.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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“…The dihedral angle between the triazole ring (N1/N2/C1/N4/C2) and the phenyl ring C4-C9 is 1.25(2)° and for the triazole ring (N5/N6/C10/N7/C11) and the phenyl ring C13-C18 is 1.82(2)°. The C(3)═N(4) bond length in the triazole ring is 1.284(3) Å, while the C( 12)═N (8) bond length in the triazole ring is 1.276(3) Å. These bond distances are longer than a typical carbon-nitrogen double bond (C═N) [1.269 (2) Å] [58] .…”

Section: Figure 3 Uv-vis Spectrum Of the Ligand L And Its Sm(iii)-adductmentioning

confidence: 93%

“…In recent years, lanthanide coordination chemistry has developed, not only for its attractive topology and interesting architectures [1][2][3] , but also to provide a wide range of applications, as such compounds can be used as antibacterial, anticancer and fungicidal agents. They also find applications in materials science, luminescent biology sensors, and self-assemblies of difference-enhancing factors [4][5][6][7][8][9][10] . Also, such compounds have potential applications in magnetism, electronic apparatus and bimetallic catalysis [11,12] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Crystal Structure of Samarium(III)-(E)-1-phenyl-N-(4H-1,2,4-triazol-4-yl)methanimine Complex

Abu-Yamin¹

2021

JJC

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Samarium-benzylidene Schiff base adduct with the formula [Sm(NO3)3(H2O)3].2L (L= (E)-1-phenyl-N-(4H-1,2,4-triazol-4-yl) methanimine) (1) has been prepared, with two water molecules bonded to the samarium center form hydrogen bond with three molecules of title Schiff base through nitrogen atoms of the triazole rings. The chemical structure was confirmed by means of single-crystal X-ray diffraction (scXRD), FT-IR, electrical conductivity, thermogravimetric analysis (TGA), mass spectrometry and elemental analysis. The title complex 1 crystallizes in the triclinic P-1 space group. The unit cell parameters are a = 10.4045(1) Å, b = 12.5403(1) Å, c = 12.5477(2) Å,  = 96.668(1)o,  = 110.810(1)o,  = 111.567(1)o, V = 1.788 Å3, Z = 2, Rgt(F) = 0.0223, wRref(F2) = 0.0576. The samarium ion is in a distorted capped square antiprism environment, coordinated by three bidentate nitrates and three coordination water molecules. The [Sm(H2O)3(NO3)3] complex and the (E)-1-phenyl-N-(4H-1,2,4-triazol-4-yl)methanimine) moiety (L) are held together via hydrogen interactions to form a 2-D supramolecular framework. It is a non-electrolyte as indicated by its molar conductivity (ΛM= 10.1 S cm2 mol-1) in MeOH at 1.0 mM. The mass spectral results confirm the suggested structure of the investigated adduct.

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“…These compounds are used in luminescent biology sensors, materials science, and selfassemblies of contrast-enhancing factors, as well as in medicine such as anticancer, antibacterial, and fungicidal properties. [1][2][3][4][5][6][7] The binding of lanthanide compounds with macromolecules (e.g., DNA and proteins) is an exciting part for both biochemists and inorganic chemists. 8,9 The interactions of compounds with DNA propose that these compounds can have potential pharmaceutical and biological activities that depend on the affinity of the interaction mode with DNA.…”

Section: Introductionmentioning

confidence: 99%

In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

2020

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Synthesis, characterization and antitumor activity of two new dipyridinium ylide based lanthanide(III) complexes

Cited by 14 publications

References 47 publications

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Synthesis, Characterization and Crystal Structure of Samarium(III)-(E)-1-phenyl-N-(4H-1,2,4-triazol-4-yl)methanimine Complex

In vitro anticancer activity of parent and nano-encapsulated samarium(iii) complex towards antimicrobial activity studies and FS-DNA/BSA binding affinity

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