Synthesis, characterization, and antitumor activity of three ternary dinuclear copper (II) complexes with a reduced Schiff base ligand and diimine coligands in vitro and in vivo

Jia, Lei; Xu, Jun; Zhao, Xiao-Lei; Shen, Shanshan; Zhou, Tao; Xu, Zhouqing; Zhu, Tao; Chen, Ruhua; Ma, Tieliang; Xie, Jing; Dong, Kun; Huang, Jiancui

doi:10.1016/j.jinorgbio.2016.02.033

Cited by 48 publications

(24 citation statements)

References 44 publications

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“…They have large orbital contribution since the spin-only formula for three unpaired electrons is only 3.88 BM. This value is attributed to threefold orbital degeneracy 4 T 1g ground state [17]. Magnetic moment of the Cr(III) complex was 4.09 BM at room temperature, which is close to the predicted value for three unpaired electrons in the metal ion [18,19].…”

Section: Resultssupporting

confidence: 67%

“…The electronic spectra of octahedral Co(II) species are theoretically expected to have three spin-allowed transitions from the ground state: 4 T lg(F) to 4 T 2g(F) , 4 A 2g(F) and 4 T 1g(P) , referred to hereafter as t 1 , t 2 and t 3 , respectively. In addition, spin-forbidden transitions to doublet terms may appear.…”

Section: Uv-vis Spectra Of Complexesmentioning

confidence: 99%

“…(iii) In octahedral fields of oxygen-coordinating ligands, the value of the crystal field splitting parameter, Dq, is such that the energy of 4 A 2g(F) is nearly coincident with that of 4 T 1g(p) . This is expected to cause overlapping of t 2 and t 3 leading to masking of the weak t 2 by the intense broad t 3 [20].…”

Section: Uv-vis Spectra Of Complexesmentioning

confidence: 99%

“…p* transitions of the azomethine group and to the presence of charge transfer transition, respectively [21,22]. Also, band at 470 nm assignable to [ 4 T 1g (F) 4 T 1g (P)] transition, characteristic of octahedral geometry [23].…”

Section: Uv-vis Spectra Of Complexesmentioning

confidence: 99%

“…Schiff base ligands are easily synthesized and form complexes with almost all metal ions. Over the past few years, there have been many reports on their applications in biology including antibacterial [1], antifungal [2], anticancer [3], antioxidant, antiinflammatory [4], antimalarial [5], antiviral activity [6] and also as catalyst in several reactions such as polymerization reaction, reduction of thionyl chloride, oxidation of organic compounds, reduction reaction of ketones, aldol reaction, Henry reaction, epoxidation of alkenes, hydrosilylation of ketones, Diels-Alder reaction [7,8]. The central metal ions in these complexes act as active sites for catalyzing chemical reactions such as oxidation of toluene.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Co(II) and Cr(III) salicylidenic Schiff base complexes derived from thiourea as precursors for nano-sized Co3O4 and Cr2O3 and their catalytic, antibacterial properties

Kafi‐Ahmadi

Shirmohammadzadeh

2017

J Nanostruct Chem

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This study focuses on the synthesis of Co(II) and Cr(III) Schiff base complexes obtained from thiourea. The complexes were synthesized by template method and characterized by elemental analysis (CHNS), FT-IR, UVvis spectroscopy, conductivity measurement and magnetic moment. The spectroscopic studies suggested the octahedral and square-pyramidal structures for Co(II) and Cr(III) complexes, respectively. Then the complexes were used as precursors for preparation of Co 3 O 4 and Cr 2 O 3 nanoparticles via solid-state thermal decomposition without using a catalyst, toxic solvent, template or surfactant and complicated equipment, which makes it efficient, one-step, simple and environment-friendly. The chemical structure of the metal oxides is studied by FT-IR, XRD and SEM. To investigate the applications of the synthesized complexes, in the next step, the complexes were screened for antibacterial activity against clinically important bacteria such as Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The Cr(III) and Co(II) complexes showed good biological activity against all the tested bacteria. Also, the catalytic activities of the complexes were studied in toluene using non-toxic hydrogen peroxide as the oxidant. The results showed that Co(II) complex has catalytic activity for oxidation of toluene, but Cr(III) complex did not show any catalytic activity.

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Section: Resultssupporting

confidence: 67%

Section: Uv-vis Spectra Of Complexesmentioning

confidence: 99%

Section: Uv-vis Spectra Of Complexesmentioning

confidence: 99%

Section: Uv-vis Spectra Of Complexesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis of Co(II) and Cr(III) salicylidenic Schiff base complexes derived from thiourea as precursors for nano-sized Co3O4 and Cr2O3 and their catalytic, antibacterial properties

Kafi‐Ahmadi

Shirmohammadzadeh

2017

J Nanostruct Chem

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Macro‐ and nano‐oligomers ternary metal complexes preparation, structural elucidation: Antimicrobial, anticancer activities, and mechanistic study of Cu nanocomplexes on liver carcinoma

Rabie

Khalil

Elaasser

et al. 2021

Applied Organom Chemis

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A new binuclear transition metal complexes of Co (II) and Cu (II) have been synthesized in both bulk and nanosized formations. The complexes were synthesized by the reaction between equimolar quantities of the metal sulfate with nitrilotriacetic acid and creatine. The nanosized forms are controlled by using (CTAB). Characterization of the nanocomplexes has been done using a transmission electron microscope (TEM) and X‐ray diffraction. This technique is considered a novel approach to the synthesis of the nanoternary complexes. The Co (II) and Cu (II) complexes displayed distorted dimeric octahedral and tetrahedral structures, respectively. The prepared metal complexes were investigated by electronic spectral analysis, magnetic susceptibility measurement, infrared spectra, thermal gravimetric analysis (TGA), UV–visible spectra, and mass spectra. The molecular weights of the dimer complexes are measured by GPC (Gel Permeation Chromatography). Characterization of the obtained complexes showed that the NTA ligand coordinates with metal ions in tridentate mode (one N and two COO−) after deprotonation, the creatine molecule coordinates through the carboxylate group, while the dimeric structure of these complexes formed with one of the sulfate groups which coordinates as a bridged bidentate ligand. Investigation of the biological activity of these complexes, as well as their hepatocellular carcinoma (HepG2) cell line inhibitory, has also been achieved.

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Solvent-free selective oxidation of alcohols with tert-butyl hydroperoxide catalyzed by dioxo-molybdenum (VI) unsymmetrical Schiff base complex immobilized on CoFe2O4@SiO2 nanoparticles

Ardakani

Naeimi

2022

Res Chem Intermed

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Synthesis, characterization, and antitumor activity of three ternary dinuclear copper (II) complexes with a reduced Schiff base ligand and diimine coligands in vitro and in vivo

Cited by 48 publications

References 44 publications

Synthesis of Co(II) and Cr(III) salicylidenic Schiff base complexes derived from thiourea as precursors for nano-sized Co3O4 and Cr2O3 and their catalytic, antibacterial properties

Synthesis of Co(II) and Cr(III) salicylidenic Schiff base complexes derived from thiourea as precursors for nano-sized Co3O4 and Cr2O3 and their catalytic, antibacterial properties

Macro‐ and nano‐oligomers ternary metal complexes preparation, structural elucidation: Antimicrobial, anticancer activities, and mechanistic study of Cu nanocomplexes on liver carcinoma

Solvent-free selective oxidation of alcohols with tert-butyl hydroperoxide catalyzed by dioxo-molybdenum (VI) unsymmetrical Schiff base complex immobilized on CoFe2O4@SiO2 nanoparticles

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