Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

Abstract

This paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.

Tris(2-amino-1,3-thiazolium) hydrogen sulfate sulfate monohydrate

“…For use of 2aminothiazole and its derivatives in medicine, see: De et al (2008); Aridoss et al (2009) ;Franklin et al (2008); Li et al (2009); Alexandru et al (2010). For the non-linear optical properties of similar aminotriazole compounds, see: Yesilel et al (2008); Matulková et al (2007Matulková et al ( , 2008 Table 1 Hydrogen-bond geometry (Å , ).…”

“…Anti-inflammatory, analgesic and antipyretic activities were observed for thiazolyl and benzothiazolyl derivatives (Franklin et al, 2008). The medical application of metal complexes of 2-aminothiazole and its derivatives involve their use as inhibitors of human cancer, Alzheimers disease, antitumor activity and activity against leukemia (Li et al, 2009;Alexandru et al, 2010).…”

2-Amino-1,3-thiazolium dihydrogen phosphate

“…For metal complexes of 2-aminothiazole and its derivatives used in medicine, see: De et al (2008); Aridoss et al (2009); Cukurovali et al (2006); Franklin et al (2008); Li et al (2009); Alexandru et al (2010); Mura et al (2005). For the use of 2aminothiazole in the decontamination of aqueous media or ethanol fuel, see: Cristante et al (2006Cristante et al ( , 2007; Takeuchi et al (2007).…”

“…Metal complexes of 2-aminothiazole and its derivatives have been studied for treatment of Alzheimers disease (Li et al, 2009), antitumor activity (Alexandru et al, 2010), and activity against leukemia (Mura et al, 2005). Thiazole derivatives have been used as antioxidants (De et al, 2008), antibacterial drugs (Aridoss et al, 2009) and fungicides (Cukurovali et al, 2006).…”

Dichloridobis[ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate-κ2 O,N 3]cadmium

“…We have recently determined the crystal structures of metal complexes with EATA or ATA as ligands, including bicoordinated [Ag(C 7 H 10 N 2 O 2 S) 2 ]NO 3 (Zhang et al, 2008a), four-coordinated 2-amino-4-thiazole acetic acid (ATAA) (Zhang et al, 2008b), five-coordinated [Zn(C 5 H 5 N 2 O 2 S) 2 (H 2 O)] (Zhang et al, 2009). Single crystal structure determinations of five-coordinated Ni II (He et al, 2009), Mn II (Alexandru et al, 2010) and Zn II (Siddiqui et al, 2009;Yang et al, 2009) complexes with aminothiazole acetate (ATA) derivative have been carried out by other groups, and it is found that the corresponding Cu II and Mn II complexes exhibit promising antitumor activity against cancerous cells (HeLa) (Alexandru et al, 2010). Here, we report a new six-coordinated title complex [Cd(C 7 H 10 N 2 O 2 S) 2 Cl 2 ], I, using EATA as ligand.…”