Synthesis, characterization, and antioxidant activity study of a novel Pt-cyclopropa[60]fullerene complex/graphene oxide nanozyme

Moniriyan, Faezeh; Sabounchei, Seyyed Javad; Jaymand, Mehdi; Derakhshankhah, Hossein

doi:10.1007/s10853-022-07312-7

Cited by 6 publications

(3 citation statements)

References 88 publications

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“…The synthesized complex was evaluated for its RSA capabilities in light of the antiradical properties of chromone-based metal complexes. , Radical scavenging activity (RSA) of the complex toward DPPH (Sigma-Aldrich) was used to investigate its effectiveness using UV–visible spectrophotometry.…”

Section: Methodsmentioning

confidence: 99%

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Preparation of a Pt(II)–3-Hydroxy-2-tolyl-4H-chromen-4-one Complex Having Antimicrobial, Anticancerous, and Radical Scavenging Activities with Related Computational Studies

Mohmad,

Agnihotri,

Kumar

et al. 2023

ACS Omega

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A novel benzopyran-based platinum (II)–3-hydroxy-2-tolyl-4 H -chromen-4-one (HToC) complex has been prepared and studied by UV–visible spectrophotometry. The study is based on the colored complexation between Pt(II) and HToC in the pH range of 8.92–9.21, resulting in the formation of a stable binary yellow complex exhibiting λ max at 509–525 nm. The formed complex maintains linearity between 0.0 and 1.8 μg Pt(II) mL –1 . The well-known qualitative analytical methods, including Job’s method of continuous variations and the mole ratio approach, have both proven that the stoichiometry of the complex is 1:2 [Pt(II)/HToC]. Hence, the analytical results suggest that the formed platinum complex exhibits a square planar geometry. The values of various attributes corresponding to spectrophotometric studies and statistical calculations, such as the molar extinction coefficient (6.790 × 10 4 L mol –1 cm –1 ), Sandell’s sensitivity (0.0029 μg Pt(II) cm –2 ), standard deviation (± 0.0011), RSD (0.317%), limit of detection (0.0147 μg mL –1 ) and correlation coefficient (0.9999), show that the performed study satisfies all of the criteria for good sensitivity, versatility, and cost-effectiveness. In order to have an apprehension of the molecular geometry and other structural specifics of the complex, DFT studies have been carried out. The in vitro anticancer potential of the ligand and its platinum complex in the human breast cancer cell line (T-27D), as determined by the MTT assay, reveals that the complex has better antiproliferative potential than the ligand. The antimicrobial potential of the complex has been successfully tested against both Gram-positive and -negative bacteria. Antioxidant capacity results suggest the better radical scavenging capacity of the complex than that of the ligand.

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Section: Methodsmentioning

confidence: 99%

“…Owing to the specific interaction with various biomolecules, platinum and its complexes possess eye-catching remedial properties. Besides the cytotoxic potential, antimicrobial − and antioxidant potential , of benzopyran-based platinum complexes is well established.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Pt(II)–3-Hydroxy-2-tolyl-4H-chromen-4-one Complex Having Antimicrobial, Anticancerous, and Radical Scavenging Activities with Related Computational Studies

Mohmad,

Agnihotri,

Kumar

et al. 2023

ACS Omega

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“…14,15 Nevertheless, both therapies require either intraperitoneal or intrarectal administration which can be uncomfortable for patients, while the extreme hydrophobicity of C 60 allows for a serious aggregation, further worsening its in vivo administration efficiency and even causing intestinal disorder. 16 Another potential problem is that the ROS scavenging effect resulting from high exogenous dosage of C 60 cannot last for too long time, [17][18][19] while in-depth research on its possible act in repairing the intestinal barrier, which benefits the long-term recovery from UC, remains limited.…”

Section: Introductionmentioning

confidence: 99%

Ulcerative colitis alleviation of colon-specific delivered rhamnolipid/fullerene nanocomposites via dual modulation in oxidative stress and intestinal microbiome

et al. 2023

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Recent Advances in Enzyme‐Based Biomaterials Toward Diabetic Wound Healing

Wang

Luo

et al. 2022

Advanced NanoBiomed Research

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Diabetic wound, also known as diabetic foot ulcer (DFU), is a form of chronic lesion that disrupts the patient's lifestyle and, in severe cases, may be fatal. Recent endeavors utilizing enzymes, particularly nanozymes in conjunction with other materials, have revealed the potential to treat diabetic wounds. Herein, the rational structural design of enzyme‐based biomaterials is summarized after presenting the types and processes of enzymes employed in diabetic wound healing, with the goal of better understanding the interaction between enzymes and other biological materials. The importance of enzyme catalytic activity, coupled with new therapeutic treatment strategies, is emphasized in the use of enzyme‐based biomaterials for diabetic wound healing. This review represents the most recent development in enzyme‐based biomaterials innovation for diabetic wound healing applications, and it can be used as a reference to guide other regenerative biomedicines from nanoenzyme biomaterials.

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Synthesis, characterization, and antioxidant activity study of a novel Pt-cyclopropa[60]fullerene complex/graphene oxide nanozyme

Cited by 6 publications

References 88 publications

Preparation of a Pt(II)–3-Hydroxy-2-tolyl-4H-chromen-4-one Complex Having Antimicrobial, Anticancerous, and Radical Scavenging Activities with Related Computational Studies

Preparation of a Pt(II)–3-Hydroxy-2-tolyl-4H-chromen-4-one Complex Having Antimicrobial, Anticancerous, and Radical Scavenging Activities with Related Computational Studies

Ulcerative colitis alleviation of colon-specific delivered rhamnolipid/fullerene nanocomposites via dual modulation in oxidative stress and intestinal microbiome

Recent Advances in Enzyme‐Based Biomaterials Toward Diabetic Wound Healing

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