Synthesis, characterization, and antioxidant activity of Zn2+ and Cu2+ coordinated polyhydroxychalcone complexes

Sulpizio, Chiara; Müller, Simon T. R.; Zhang, Qi; Brecker, Lothar; Rompel, Annette

doi:10.1007/s00706-016-1822-7

Cited by 28 publications

(13 citation statements)

References 46 publications

(44 reference statements)

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“…The obtained results were in agreement with several works reported in the literature with regards to the antioxidant potential of metal complexes. In a recent study, Sulpizio et al . have reported that the metal complexes [Cu (ISO) 2 ] and [Zn (ISO) 2 ] show 72 and 88% inhibition of the DPPH radical.…”

Section: Resultsmentioning

confidence: 99%

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Hfidhi

Bkhairia

Atoui

et al. 2019

Applied Organom Chemis

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Hydrothermal reaction of copper bromide with 4‐aminopyridine in DMF solution yields a new mononuclear copper complex [Cu(C5H6N2)4]2Br.2(C3H7NO) abbreviated Cu‐4AP‐Br. The product was characterized, structurally, by single‐crystal X‐ray diffraction analysis and, thermally, by DSC‐ATG measurement. The inorganic–organic hybrid compound Cu‐4AP‐Br crystallizes in the centrosymmetric space group Pbcn, exhibiting a supramolecular network. Simultaneous DSC‐ATG analysis shows that this compound remains stable up to 100 °C and then performs a successive decompositions accompanied with endothermic peaks. The complex Cu‐4AP‐Br was applied as a catalyst in the Heck coupling reaction under ultrasonic irradiation in various reaction conditions. The yields, obtained for a short period of time, allow us to consider this complex, generating selectivity on the external position of styrene with a preference of the trans form over cis, as an excellent catalyst for this type of reaction. Interestingly, Cu‐4AP‐Br displayed important antibacterial (Gram‐positive and Gram‐negative) and antioxidant activities (β‐carotene bleaching inhibition, scavenging effect on DPPH free radical, and reducing power).

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Section: Resultsmentioning

confidence: 99%

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Hfidhi

Bkhairia

Atoui

et al. 2019

Applied Organom Chemis

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“…The M-O band for Zn(II) was observed at 500 cm -1 . Chiara Sulpizio assigned that, [9] Zn +2 do not show any significant shift compared to the free ligand. While the Zn +2 complexes show a shift of C=0 stretching mode from 1630 to 1610 cm -1 indicating coordination of carbonyl oxygen to a metal ion.…”

Section: IIImentioning

confidence: 98%

Synthesis, Spectral Study, Characterization and Antimicrobial Activity of Zinc (II) Complex of Chalcone of Pyridine-2-Carbaldehyde

Ipper¹

2019

IJRASET

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Metal complex of Zn(II) has been synthesized with newly prepared biologically active ligand. This ligand was prepared by the Claisen-Schmidt condensation method of 2,6-dihydroxy acetophenone and pyridine-2-Carbaldehyde. The structure of the complex has been proposed by the analytical data, conductivity measurement, magnetic moment, IR spectrum, Electronic absorption spectrum, thermal studies and XRD analysis. Analytical data confirmed 1:2 stoichiometry and the electronic spectral data, IR, magnetic moment, TG-DTA suggests that Zn(II) complex has square planar geometry. Absence of coordinated water molecules in Zn(II) complex is confirmed by TG-DTA studies. The conductivity data show that the complex is non electrolyte. Antimicrobial activities of complex with selected bacterial strain and fungal strain carried out and the results have been compared with commercial standards. In this paper we prepare chalcone of pyridine-2-Carbaldehyde by Claisen-Schmidt condensation method and synthesize Zn (II) metal complex and characterize them by Infrared, Electronic absorption spectra, magnetic susceptibility, CHO analysis, solution conductivity, XRD study, TG-DTA and antimicrobial activity.

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“…The percentage of inhibition (I%) of free radical production by DPPH was calculated using the formula, (I%) = [(A0 -Ac)/A0]  100 where A0 and Ac are the absorbance in the absence and presence of the metal complexes respectively. [32]…”

Section: Antioxidant Activitymentioning

confidence: 99%

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Saritha

Reddy

Sireesha

2021

Vietnam Journal of Chemistry

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The synthesis, characterization of mixed ligand chelates of Ni(II), [NiAL] involving Pyridoxalthiosemicarbazone (A) and dipeptides (L) viz., glycyl‐glycine (gly‐gly), glycyl‐L‐leucine (gly‐leu), glycyl‐L‐tyrosine (gly‐tyr) and glycyl‐L‐valine (gly‐val) and their biological activities have been studied. The complexes were characterized based on their elemental analysis, LC‐MS, IR, UV‐Vis spectral studies, magnetic moment, molar conductance and thermal analysis. The mixed ligand complexes were formed with 1:1:1 (Ni:A:L) ratio. The molar conductance data reveal the non‐electrolytic nature of the metal chelates. IR spectra show that the ligands are coordinated to the metal ion in a tridentate manner, involving O,N,S and O,N,N donor sites of ligands, A and L respectively. Based on the analytical data, octahedral geometry has been proposed for the metal complexes. DNA binding properties of the complexes have been investigated by UV‐Vis and fluorescence spectroscopy and also by viscosity measurements. The obtained results indicate that the complexes bind to DNA through intercalation mode, which is further validated by molecular docking studies. The hydrolytic cleavage of the pBR322 DNA from supercoiled to nicked form, by the metal complexes was investigated by gel electrophoresis technique. The metal complexes were also screened for their antioxidant, anti‐inflammatory and antibacterial activities and the findings have been reported.

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Synthesis, characterization, and antioxidant activity of Zn2+ and Cu2+ coordinated polyhydroxychalcone complexes

Cited by 28 publications

References 46 publications

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Synthesis, Spectral Study, Characterization and Antimicrobial Activity of Zinc (II) Complex of Chalcone of Pyridine-2-Carbaldehyde

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

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