Synthesis, Characterization and Antimicrobial Studies of Co(II), Ni(II), Cu(II) and Zn(II) Complexes of (E)-2-(4-Dimethylbenzydimino)-Glycylglycine, (Glygly-DAB) a Schiff Base Derived from 4-Dimethylaminobenzaldehyde and Glycylglycine

Kuate, Maurice; Conde, Mariam Asseng; Nchimi, Katia Nono; Paboudam, Awawou G.; Ntum, Sally-Judith E.; Ndifon, Peter T.

doi:10.4236/ijoc.2018.83022

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…In addition, the action of Schiff base ligand metal complexes as the antioxidant agent was evaluated by ferrous ion chelating assay and DPPH radical scavenging assay, in which the metal complexes showed their excellent performance compared to ascorbic acid [48]. Kuate et al (2018) have reported the selective antimicrobial activity of metal complexes of Schiff base ligand (21) derived from the condensation of 4-Dimethylaminobenzaldehyde with glycylglycine. They were tested for antimicrobial evaluation against four bacterial and two fungal specimens via the disc diffusion technique.…”

Section: Chemotherapeutic Applicationsmentioning

confidence: 99%

“…They were tested for antimicrobial evaluation against four bacterial and two fungal specimens via the disc diffusion technique. Based on the comparative result, they reached in the conclusion that the Zn and Ni inclusive Schiff base complexes were more efficient against C. neoformans, S. aureus, and S. thyphi pathogens than the other metal complexes with MIC values of 2x10 -3 , 2.5x10 -2 , and 2x10 -2 respectively [49]. In the fight against multidrug-resistant pathogens, it is advised often used narrow-spectrum antibiotics [50], i.e.…”

Section: Chemotherapeutic Applicationsmentioning

confidence: 99%

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Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

et al. 2021

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The discovery of new chemotherapeutics with novel bioactivities and functionalities to fight current emerging diseases has become the most significant research in pharmaceutical science. Schiff bases are versatile pharmacophores that can form complexes by chelation with metals of different oxidation states. Over a few decades of intensive research on metal-based drugs, Schiff base metal complexes have been considered as the active field of research in coordination chemistry, owing to their valuable applications in various fields of science. As therapeutic drugs, they have potential applications as antibiotic, antimicrobial, antitumor, antiviral, anti-inflammatory, analgesic, antifungal, and many more. There has been a global threat of drug resistance in medical science in recent years because most of the pathogenic organisms are developing the ability to deactivate drug substances. For this reason, it requires urgent attention from chemical and pharmaceutical scientists to address the severe challenges of multidrug resistance. This review summarizes the current developments in the last few decades' research on the chemotherapeutic activities of Schiff base metal complexes. BIBECHANA 18 (2021) 214-230

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Section: Chemotherapeutic Applicationsmentioning

confidence: 99%

Section: Chemotherapeutic Applicationsmentioning

confidence: 99%

Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

et al. 2021

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“…Interest in the use of transition metal complexes with Schiff bases in medicine began to develop in the second half of the 19th century. Co(II), Ni(II), Cu(II) and Zn(II) complexes exhibit exceptional biological activity [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. In recent years, there has been greater interest in the possibility of using metal ions such as Ag(I), Au(I) or Pt(II) in medicine [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Different Schiff Bases—Structure, Importance and Classification

et al. 2022

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Schiff bases are a vast group of compounds characterized by the presence of a double bond linking carbon and nitrogen atoms, the versatility of which is generated in the many ways to combine a variety of alkyl or aryl substituents. Compounds of this type are both found in nature and synthesized in the laboratory. For years, Schiff bases have been greatly inspiring to many chemists and biochemists. In this article, we attempt to present a new take on this group of compounds, underlining of the importance of various types of Schiff bases. Among the different types of compounds that can be classified as Schiff bases, we chose hydrazides, dihydrazides, hydrazones and mixed derivatives such as hydrazide–hydrazones. For these compounds, we presented the elements of their structure that allow them to be classified as Schiff bases. While hydrazones are typical examples of Schiff bases, including hydrazides among them may be surprising for some. In their case, this is possible due to the amide-iminol tautomerism. The carbon–nitrogen double bond present in the iminol tautomer is a typical element found in Schiff bases. In addition to the characteristics of the structure of these selected derivatives, and sometimes their classification, we presented selected literature items which, in our opinion, represent their importance in various fields well.

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“…Complexes of Schiff bases have been extensively studied as potential antibacterial, antifungal, and anticancer agents [11][12][13]. Tridentate Schiff base complexes having oxygen, nitrogen, and sulfur donor atoms have been reported to possess unusual structure [14], antimicrobial [15,16], anti-inflammatory [17,18], antiviral, anticancer [19], and electrochemical properties [20,21]. In recent years, tridentate Schiff bases derived from aminophenol received enormous attention as ligands due to their metal-binding ability and their various applications.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, tridentate Schiff bases derived from aminophenol received enormous attention as ligands due to their metal-binding ability and their various applications. Our group has recently embarked on studies on the biological activities of complexes of heterocyclic Schiff base ligands [15,22]. One such class of heterocyclic Schiff base ligands is the pyridine carboxaldehyde isonicotinoyl hydrazones, derived from isoniazid (isonicotinic acid hydrazide) which are generally bidentate or tridentate chelators and typically form six-coordinate complexes [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Cyclic Voltammetry, and Biological Studies of Co(II), Ni(II), and Cu(II) Complexes of a Tridentate Schiff Base, 1-((E)-(2-Mercaptophenylimino) Methyl) Naphthalen-2-ol (H2L1)

Kuate

Conde

Mainsah

et al. 2020

Journal of Chemistry

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A novel tridentate Schiff base, 1-((E)-(2-mercaptophenylimino) methyl) naphthalen-2-ol (H2L1), was synthesized by the condensation reaction of 2-hydroxy-1-naphthaldehyde with 2-aminothiophenol in absolute ethanol. The resulting ligand was reacted with Co(II), Ni(II), and Cu(II) ions to obtain tetrahedral CoL1, NiL1, and square planar CuL1 complexes. The Schiff base and its metal complexes were characterized using 1H-NMR, microanalysis, FT-IR, UV-visible, and mass spectroscopy (ESI-MS). All the compounds are soluble in DMSO and DMF. Spectroscopic studies show that the ligand coordinates to the metal center through the azomethine nitrogen, naphthoxide oxygen, and thiophenoxide sulfur to form a tridentate chelate system. Conductance measurements show that these compounds are molecular in solution. Cyclic voltammetry studies show Co(III)/Co(II) and Cu(II)/Cu(I) redox systems to be quasi-reversible involving a monoelectronic transfer while Ni(III)/Ni(II) was irreversible. In vitro antibacterial and antifungal activity against five bacterial strains (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, and Proteus mirabilis) and five fungal strains (Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsilosis) showed no antifungal activity but moderate antibacterial activity on E. coli, S. aureus, P. aeruginosa, and P. mirabilis bacterial strains. Antioxidant studies reveal that the ligand and its Cu(II) complex are more potent than Co(II) and Ni(II) complexes to eliminate free radicals.

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Synthesis, Characterization and Antimicrobial Studies of Co(II), Ni(II), Cu(II) and Zn(II) Complexes of (E)-2-(4-Dimethylbenzydimino)-Glycylglycine, (Glygly-DAB) a Schiff Base Derived from 4-Dimethylaminobenzaldehyde and Glycylglycine

Cited by 9 publications

References 12 publications

Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

Different Schiff Bases—Structure, Importance and Classification

Synthesis, Characterization, Cyclic Voltammetry, and Biological Studies of Co(II), Ni(II), and Cu(II) Complexes of a Tridentate Schiff Base, 1-((E)-(2-Mercaptophenylimino) Methyl) Naphthalen-2-ol (H2L1)

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